Evaluation of the drug –drug interaction potential of brigatinib using a physiologically‐based pharmacokinetic modeling approach
AbstractBrigatinib is an oral anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment ofALK-positive metastatic non-small cell lung cancer. In  vitro studies indicated that brigatinib is primarily metabolized by CYP2C8 and CYP3A4 and inhibits P-gp, BCRP, OCT1, MATE1, and MATE2K. Clinical drug–drug interaction (DDI) studies with the strong CYP3A inhibitor itraconazole or the strong CYP3A inducer rifampin demonstrated that CYP3A-mediated metabolism was the primary contributor to overall brigatinib clearance in humans. A physiologically-based pharmacokinetic (PBPK) model for brigatinib was developed to predic...
Source: CPT: Pharmacometrics and Systems Pharmacology - January 31, 2024 Category: Drugs & Pharmacology Authors: Michael J. Hanley, Karen Rowland Yeo, Meera Tugnait, Shinji Iwasaki, Narayana Narasimhan, Pingkuan Zhang, Karthik Venkatakrishnan, Neeraj Gupta Tags: ARTICLE Source Type: research

The combination of doxazosin and metyrosine as a preoperative treatment for pheochromocytomas and paragangliomas
ConclusionThe combination of metyrosine and doxazosin as a preoperative treatment for PPGLs affects intraoperative circulatory hemodynamics, such as a reduced occurrence of blood pressure elevation during surgery. Further research is necessary to identify patients who will benefit most from this combination treatment. (Source: Endocrine)
Source: Endocrine - January 11, 2024 Category: Endocrinology Source Type: research

Acute Management Of Atrial Fibrillation: Comparison Of Metoprolol And Diltiazem In Early Rate Control
This study analyzed the outcomes of patients who received IV CCB or BB for acute rate control of AF in the emergency department (ED). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Kaitlyn Withers, Wesley Parker, Adam Schertz, Jonathan Mayl, Drake Scott, Abigail Thomas, Stephanie Ira, Patrick Whalen, Ghanshyam Shantha, Prashant Bhave, Barbara Pisani Tags: 442 Source Type: research

Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
CONCLUSIONS: The study found that anemia, co-administration of gemfibrozil, co-administration of verapamil or diltiazem, INR, heart failure, myocardial infarction et al. were associated with anticoagulation-related GIB, and these factors were not in the existing prediction models. This study informs risk prediction for anticoagulant-associated GIB, it also informs guidelines for GIB prevention and future research.PMID:38062723 | DOI:10.3904/kjim.2023.098 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 8, 2023 Category: Internal Medicine Authors: Fuxin Ma Shuyi Wu Shiqi Li Zhiwei Zeng Jinhua Zhang Source Type: research

Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
CONCLUSIONS: The study found that anemia, co-administration of gemfibrozil, co-administration of verapamil or diltiazem, INR, heart failure, myocardial infarction et al. were associated with anticoagulation-related GIB, and these factors were not in the existing prediction models. This study informs risk prediction for anticoagulant-associated GIB, it also informs guidelines for GIB prevention and future research.PMID:38062723 | DOI:10.3904/kjim.2023.098 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 8, 2023 Category: Internal Medicine Authors: Fuxin Ma Shuyi Wu Shiqi Li Zhiwei Zeng Jinhua Zhang Source Type: research

Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
CONCLUSIONS: The study found that anemia, co-administration of gemfibrozil, co-administration of verapamil or diltiazem, INR, heart failure, myocardial infarction et al. were associated with anticoagulation-related GIB, and these factors were not in the existing prediction models. This study informs risk prediction for anticoagulant-associated GIB, it also informs guidelines for GIB prevention and future research.PMID:38062723 | DOI:10.3904/kjim.2023.098 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 8, 2023 Category: Internal Medicine Authors: Fuxin Ma Shuyi Wu Shiqi Li Zhiwei Zeng Jinhua Zhang Source Type: research

Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
CONCLUSIONS: The study found that anemia, co-administration of gemfibrozil, co-administration of verapamil or diltiazem, INR, heart failure, myocardial infarction et al. were associated with anticoagulation-related GIB, and these factors were not in the existing prediction models. This study informs risk prediction for anticoagulant-associated GIB, it also informs guidelines for GIB prevention and future research.PMID:38062723 | DOI:10.3904/kjim.2023.098 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 8, 2023 Category: Internal Medicine Authors: Fuxin Ma Shuyi Wu Shiqi Li Zhiwei Zeng Jinhua Zhang Source Type: research

Sustainable Asymmetric Synthesis of Diltiazem Precursor Enabled by Recombinant Escherichia coli Whole Cells Co-Expressing an Engineered Ketoreductase and Glucose Dehydrogenase
This article is protected by copyright. All rights reserved.PMID:38048389 | DOI:10.1002/biot.202300250 (Source: Biotechnology Journal)
Source: Biotechnology Journal - December 4, 2023 Category: Biotechnology Authors: Xiaoping Yue Yitong Li Lin Yang Di Sang Zedu Huang Fener Chen Source Type: research

A novel potentiometric sensor based on ZnO decorated polyaniline/coal nanocomposite for diltiazem determination
RSC Adv. 2023 Nov 28;13(49):34715-34723. doi: 10.1039/d3ra06849h. eCollection 2023 Nov 22.ABSTRACTDiltiazem (DTZ) is one of the most effective medications for treating cardiovascular diseases. It has been widely used for the treatment of angina pectoris, hypertension and some types of arrhythmia. The development and application of a modified carbon paste sensor with improved detection limits for the potentiometric determination of diltiazem are the main goals of the current study. Sensitivity, long-term stability, reproducibility and improving the electrochemical performance are among the characteristics that have undergon...
Source: Adv Data - November 30, 2023 Category: Epidemiology Authors: G A El Sayed Mostafa R Abukhadra S M Mostafa M Rabia Mohamed Ali Korany M M Khalil Source Type: research

A novel potentiometric sensor based on ZnO decorated polyaniline/coal nanocomposite for diltiazem determination
RSC Adv. 2023 Nov 28;13(49):34715-34723. doi: 10.1039/d3ra06849h. eCollection 2023 Nov 22.ABSTRACTDiltiazem (DTZ) is one of the most effective medications for treating cardiovascular diseases. It has been widely used for the treatment of angina pectoris, hypertension and some types of arrhythmia. The development and application of a modified carbon paste sensor with improved detection limits for the potentiometric determination of diltiazem are the main goals of the current study. Sensitivity, long-term stability, reproducibility and improving the electrochemical performance are among the characteristics that have undergon...
Source: Adv Data - November 30, 2023 Category: Epidemiology Authors: G A El Sayed Mostafa R Abukhadra S M Mostafa M Rabia Mohamed Ali Korany M M Khalil Source Type: research

Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research

Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research

Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research

Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research