Exploring the Effectiveness of Carboxymethylated and Crosslinked Albizia Procera Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis
This study investigates the efficacy of modified Albizia procera gum as a release-retardant polymer in Diltiazem hydrochloride (DIL) matrix tablets. Carboxymethylated Albizia procera gum (CAP) and ionically crosslinked carboxymethylated Albizia procera gum (Ca-CAP) were utilized, with Ca-CAP synthesized via crosslinking CAP with calcium ions (Ca2+) using calcium chloride (CaCl2). FTIR analysis affirmed polymer compatibility, while Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) assessed thermal behavior and crystallinity, respectively. Zeta potential analysis explored surface charge and electrostatic in...
Source: Chemical and Pharmaceutical Bulletin - April 21, 2024 Category: Drugs & Pharmacology Authors: Sudipta Mukherjee Jasmina Khanam Source Type: research
Ketoreductase-catalyzed dynamic reductive kinetic resolution of sterically hindered 2-aryl-1,5-benzothiazepin-3,4(2H,5H)-diones: asymmetric synthesis of a key diltiazem precursor and its analogues
Green Chem., 2024, Accepted Manuscript DOI: 10.1039/D4GC01478B, PaperZijun Guo, Zexin Wu, Xiaofan Wu, Li Zhang, Zedu Huang, Fener Chen Owing to its associated advantages such as generation of two stereocenters in 100% maximum theoretical yield, mild reaction conditions and environmentally friendliness, ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution (DYRKR) is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - April 18, 2024 Category: Chemistry Authors: Zijun Guo Source Type: research
Serious Bleeding in Patients With Atrial Fibrillation Using Diltiazem With Apixaban or Rivaroxaban
This cohort study assesses the association of diltiazem with risk of serious bleeding compared with metoprolol in older adults with atrial fibrillation receiving apixaban or rivaroxaban. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 15, 2024 Category: General Medicine Source Type: research
Clinical Outcomes Associated With Diltiazem Use in Heart Failure With Reduced Ejection Fraction After Implementation of a Clinical Support System
CONCLUSION AND RELEVANCE: In patients with heart failure with reduced EF, diltiazem use after nonadherence to a CDSS alert resulted in an increased risk of clinical deterioration. This study highlights the need for improved provider adherence to diltiazem clinical decision support systems.PMID:38571388 | DOI:10.1177/10600280241243071 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 4, 2024 Category: Drugs & Pharmacology Authors: Elizabeth M Foster James C Coons Elena A Puccio Danine Sullinger Rachel Ibrahim Joseph Ibrahim Gavin W Hickey Edward Horn Vincent Mosesso Ryan M Rivosecchi Source Type: research
Clinical Outcomes Associated With Diltiazem Use in Heart Failure With Reduced Ejection Fraction After Implementation of a Clinical Support System
CONCLUSION AND RELEVANCE: In patients with heart failure with reduced EF, diltiazem use after nonadherence to a CDSS alert resulted in an increased risk of clinical deterioration. This study highlights the need for improved provider adherence to diltiazem clinical decision support systems.PMID:38571388 | DOI:10.1177/10600280241243071 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 4, 2024 Category: Drugs & Pharmacology Authors: Elizabeth M Foster James C Coons Elena A Puccio Danine Sullinger Rachel Ibrahim Joseph Ibrahim Gavin W Hickey Edward Horn Vincent Mosesso Ryan M Rivosecchi Source Type: research
Clinical Outcomes Associated With Diltiazem Use in Heart Failure With Reduced Ejection Fraction After Implementation of a Clinical Support System
CONCLUSION AND RELEVANCE: In patients with heart failure with reduced EF, diltiazem use after nonadherence to a CDSS alert resulted in an increased risk of clinical deterioration. This study highlights the need for improved provider adherence to diltiazem clinical decision support systems.PMID:38571388 | DOI:10.1177/10600280241243071 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 4, 2024 Category: Drugs & Pharmacology Authors: Elizabeth M Foster James C Coons Elena A Puccio Danine Sullinger Rachel Ibrahim Joseph Ibrahim Gavin W Hickey Edward Horn Vincent Mosesso Ryan M Rivosecchi Source Type: research
Clinical Outcomes Associated With Diltiazem Use in Heart Failure With Reduced Ejection Fraction After Implementation of a Clinical Support System
CONCLUSION AND RELEVANCE: In patients with heart failure with reduced EF, diltiazem use after nonadherence to a CDSS alert resulted in an increased risk of clinical deterioration. This study highlights the need for improved provider adherence to diltiazem clinical decision support systems.PMID:38571388 | DOI:10.1177/10600280241243071 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 4, 2024 Category: Drugs & Pharmacology Authors: Elizabeth M Foster James C Coons Elena A Puccio Danine Sullinger Rachel Ibrahim Joseph Ibrahim Gavin W Hickey Edward Horn Vincent Mosesso Ryan M Rivosecchi Source Type: research
Efficacy of diltiazem 2% rectal gel in the treatment of chronic anal fissure: a retrospective observational study
CONCLUSION: In this study, use of topical diltiazem 2% has been shown to be effective and safe in the treatment of anal fissure and should be considered as the first line of therapy.PMID:38537239 | DOI:10.24875/CIRU.22000626 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Gabriel Mart ínez-Orea Francisco J Rodr íguez-Lucena Celia Garc ía-González Nieves Cano-Cuenca Ana Candela-Fajardo Rodrigo Bonilla-Pe ñarrubia Source Type: research
Efficacy of diltiazem 2% rectal gel in the treatment of chronic anal fissure: a retrospective observational study
CONCLUSION: In this study, use of topical diltiazem 2% has been shown to be effective and safe in the treatment of anal fissure and should be considered as the first line of therapy.PMID:38537239 | DOI:10.24875/CIRU.22000626 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Gabriel Mart ínez-Orea Francisco J Rodr íguez-Lucena Celia Garc ía-González Nieves Cano-Cuenca Ana Candela-Fajardo Rodrigo Bonilla-Pe ñarrubia Source Type: research
Efficacy of diltiazem 2% rectal gel in the treatment of chronic anal fissure: a retrospective observational study
CONCLUSION: In this study, use of topical diltiazem 2% has been shown to be effective and safe in the treatment of anal fissure and should be considered as the first line of therapy.PMID:38537239 | DOI:10.24875/CIRU.22000626 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Gabriel Mart ínez-Orea Francisco J Rodr íguez-Lucena Celia Garc ía-González Nieves Cano-Cuenca Ana Candela-Fajardo Rodrigo Bonilla-Pe ñarrubia Source Type: research
Efficacy of diltiazem 2% rectal gel in the treatment of chronic anal fissure: a retrospective observational study
CONCLUSION: In this study, use of topical diltiazem 2% has been shown to be effective and safe in the treatment of anal fissure and should be considered as the first line of therapy.PMID:38537239 | DOI:10.24875/CIRU.22000626 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Gabriel Mart ínez-Orea Francisco J Rodr íguez-Lucena Celia Garc ía-González Nieves Cano-Cuenca Ana Candela-Fajardo Rodrigo Bonilla-Pe ñarrubia Source Type: research
Efficacy of diltiazem 2% rectal gel in the treatment of chronic anal fissure: a retrospective observational study
CONCLUSION: In this study, use of topical diltiazem 2% has been shown to be effective and safe in the treatment of anal fissure and should be considered as the first line of therapy.PMID:38537239 | DOI:10.24875/CIRU.22000626 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Gabriel Mart ínez-Orea Francisco J Rodr íguez-Lucena Celia Garc ía-González Nieves Cano-Cuenca Ana Candela-Fajardo Rodrigo Bonilla-Pe ñarrubia Source Type: research
Efficacy of diltiazem 2% rectal gel in the treatment of chronic anal fissure: a retrospective observational study
CONCLUSION: In this study, use of topical diltiazem 2% has been shown to be effective and safe in the treatment of anal fissure and should be considered as the first line of therapy.PMID:38537239 | DOI:10.24875/CIRU.22000626 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Gabriel Mart ínez-Orea Francisco J Rodr íguez-Lucena Celia Garc ía-González Nieves Cano-Cuenca Ana Candela-Fajardo Rodrigo Bonilla-Pe ñarrubia Source Type: research
Efficacy of diltiazem 2% rectal gel in the treatment of chronic anal fissure: a retrospective observational study
CONCLUSION: In this study, use of topical diltiazem 2% has been shown to be effective and safe in the treatment of anal fissure and should be considered as the first line of therapy.PMID:38537239 | DOI:10.24875/CIRU.22000626 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Gabriel Mart ínez-Orea Francisco J Rodr íguez-Lucena Celia Garc ía-González Nieves Cano-Cuenca Ana Candela-Fajardo Rodrigo Bonilla-Pe ñarrubia Source Type: research
Efficacy of diltiazem 2% rectal gel in the treatment of chronic anal fissure: a retrospective observational study
CONCLUSION: In this study, use of topical diltiazem 2% has been shown to be effective and safe in the treatment of anal fissure and should be considered as the first line of therapy.PMID:38537239 | DOI:10.24875/CIRU.22000626 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Gabriel Mart ínez-Orea Francisco J Rodr íguez-Lucena Celia Garc ía-González Nieves Cano-Cuenca Ana Candela-Fajardo Rodrigo Bonilla-Pe ñarrubia Source Type: research
