Mechanisms by Which Stem Cell Therapy Might Treat Skin Aging
There is some interest in the research community in targeting first generation stem cell therapies to the skin in order to reverse skin aging. These stem cell therapies use cells obtained from fat tissue or other well established sources, and in near all cases the transplanted cells near all die quite quickly following their introduction into the patient. Methods of cell production and sources of cells vary widely, and so do the observed benefits. Increased regeneration is widely claimed, but only intermittently proven. Benefits realized by patients largely derive from reductions in systemic inflammation and other effects ...
Source: Fight Aging! - May 21, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 10th 2021
This study suggests that some of those changes contribute to age-related hypertension, providing yet another reason to put resources into the near term development of therapies that can reverse the aging of the gut microbiome, such as flagellin vaccination or fecal microbiota transplantation.
"Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone) rat model, is different from that in animals with normal blood pressure. Further, transplanting dysbiotic gut microbiota from a hypertensive animal ...
Source: Fight Aging! - May 9, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mesenchymal Stem Cell Therapy as a Treatment for Skin Aging
The term "mesenchymal stem cell therapy" covers a very broad range of cell sources and cell capabilities. Arguably the category needs to be thrown out and replaced with a more detailed taxonomy. The results of mesenchymal stem cell therapy in one clinic can be wildly different from those in another due to small differences in protocol, even given a similar source of cells.
Taken as a whole, this class of therapy appears to fairly reliably suppress chronic inflammation for a time, while unreliably provoking increased regeneration and tissue maintenance. Transplanted cells near all die rapidly rather than integrating ...
Source: Fight Aging! - May 7, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Inhibition of EN1 Activity Heals Skin Injuries without Scarring in Mice
There is an interesting history of accidental discoveries regarding exceptional regeneration in mammals, such as the MRL mice that are capable of regenerating the ear tags and notches that researchers use to track mice through experiments, thereby causing some confusion. Researchers have since then spent time on attempts to identify important mechanisms by which mammalian regeneration takes the path of scarring, rather than the path of regrowth. The discovery noted here is an interesting one. The scientists involved have established a good proof of concept based on a regulator of scarring, EN1. When suppressed this leads t...
Source: Fight Aging! - May 3, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
May 2021: The Asphyxiants that Cause Pulmonary Toxicity
The American Association of Poison Control Centers reported more than 37,000 exposures to gas, fumes, and vapors in 2019, and those were the most common exposures in pediatric deaths. Toxicity from gas, fume, and vapor exposures can be categorized by their mechanism: simple asphyxiants, pulmonary irritants, and systemic asphyxiants.Simple AsphyxiationSimple asphyxiants work by displacing oxygen from ambient air. Patients may be exposed to these chemicals by huffing. A 2010 survey reported that more than two million adolescents in the United States ages 12-17 reported using inhalants at least once, including noble ga...
Source: The Tox Cave - April 30, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Polycystic ovary syndrome and the skin
Often, the skin can be a window to what is occurring inside your body. For women with polycystic ovary syndrome, or PCOS, this this may mean acne, hair loss, excessive facial or body hair growth, dark patches on the skin, or any combination of these issues.
What is PCOS?
Skin and hair issues can be the most readily perceptible features of PCOS, and thus sometimes the reason for seeking medical care. However, features of PCOS also include menstrual irregularities, polycystic ovaries (when the ovaries develop multiple small follicles and do not regularly release eggs), obesity, and insulin resistance (when cells do not respo...
Source: Harvard Health Blog - April 29, 2021 Category: Consumer Health News Authors: Kristina Liu, MD, MHS Tags: Diet and Weight Loss Family Planning and Pregnancy Fertility Skin and Hair Care Women's Health Source Type: blogs
There Is A Good Deal More To Recording TeleHealth Consultations Than May Be Immediately Obvious!
This appeared last week. Perils of recording telehealth consultations Authored by Cate Swannell Issue 12 / 12 April 2021 THE COVID-19 pandemic has necessitated rapid uptake and use of telehealth, exposing a “number of concerns potentially not previously contemplated by clinicians, patients and legislators”, according to the authors of an Ethics and law article published by the MJA. “Recording of clinical conversations or processes may enhance patient and clinician participation, self-reference, r esearch, education and funding,” wrote the authors, led by Dr Caitlin Farmer, a radiology registrar at Monash Health, an...
Source: Australian Health Information Technology - April 22, 2021 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Software Spots Suspicious Skin Lesions on Smartphone Photos
Melanoma, which accounts for over 70 percent of all skin cancers, occurs when pigment producing cells called melanocytes multiply uncontrollably. This cancer is typically diagnosed through visual inspection of Suspicious Pigmented Lesions (SPLs), and such early detection of lesions in a physician’s office are often life-saving. However, there are several disadvantages with this approach, including the high volume of potential lesions one has to biopsy and test before confirming a diagnosis.
To overcome these issues, researchers from MIT and a few other institutions around Boston, have developed a new deep learning...
Source: Medgadget - April 20, 2021 Category: Medical Devices Authors: Rukmani Sridharan Tags: Dermatology Informatics Oncology Source Type: blogs
Stress may be getting to your skin, but it ’s not a one-way street
Are you stressed out? Your skin can show it. Studies show that both acute and chronic stress can exert negative effects on overall skin wellness, as well as exacerbate a number of skin conditions, including psoriasis, eczema, acne, and hair loss.
But it’s not just a one-way street. Research has also shown that skin and hair follicles contain complex mechanisms to produce their own stress-inducing signals, which can travel to the brain and perpetuate the stress response.
Stress and the two-way street between your brain and skin
You may already have experienced the connection between the brain and skin. Have you ever gotte...
Source: Harvard Health Blog - April 14, 2021 Category: Consumer Health News Authors: Neera Nathan, MD, MSHS Tags: Skin and Hair Care Stress Source Type: blogs
Can science tell doctors what to wear?
In 2002, two Stanford dermatologists published a study in which they sent a questionnaire to a week ’s worth of patients, asking them their preferences for how medical providers dress. The study covered relatively new ground. Two of the four references were the 1970s best-sellers, Dress for Success, and The Woman’s Dress for Success Book. The […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 10, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/christopher-watson" rel="tag" > Christopher Watson, MD < /a > < /span > Tags: Physician Hospital-Based Medicine Primary Care Source Type: blogs
Acne: Considerations for darker skin
Acne affects millions of Americans each year and impacts people of all skin tones, yet acne can pose special challenges in people with darker skin. In darker skin, one pimple or breakout can cause dark marks, scars, or even keloids (scar tissue that continues to grow larger than the original scar) that last for months to years afterward. Those affected are left searching for the secrets to treatment — or better yet, prevention. In this post we discuss how acne and similar or related conditions may be treated, and sometimes prevented, in people with darker skin.
Acne triggers release of melanin
Melanin, the same molecule ...
Source: Harvard Health Blog - March 3, 2021 Category: Consumer Health News Authors: Arianne Shadi Kourosh, MD, MPH Tags: Skin and Hair Care Source Type: blogs
Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Upregulation of Autophagy via mTOR Inhibition Reduces Tendon Stem Cell Senescence
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 26, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A dermatologist reflects on his career [PODCAST]
“At that point, I realized Thanksgiving came early this year, and I missed it. It was a reminder of why many of us go into medicine. I didn ’t go into medicine for glory or fame. Nor did I go into medicine for financial reward. Still, I often told the resident physicians I was training, after […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 18, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Dermatology Source Type: blogs
Why We Need Good Primary Care Physicians
By HANS DUVEFELT
I have made the argument that being the first contact for patients with new symptoms requires skill and experience. That is not something everybody agrees on.
One commenter on my blog expressed the opinion that it is easy to recognize the abnormal or serious and then it is just a matter of making a specialist referral.
That is a terribly inefficient model for health care delivery. It also exposes patients to the risks of delays in treatment, increased cost and inconvenience and the sometimes irreversible and disastrous consequences of knowledge gaps in the frontline provider.
UNNECESSARY SPECIA...
Source: The Health Care Blog - February 15, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Primary Care Hans Duvefelt primary care physicians Source Type: blogs
