Elastin Structure in Tissue is Complex, as is the Aging of that Structure
In this study, we aimed to apply the decolourization technique to excised human skin tissue and to observe the 3D structure of elastin fibres. Moreover, to evaluate the elastin fibre structure objectively and quantitatively, we established a computational 3D structural analysis method for 3D imaging.
The 3D observations of the inner skin structures revealed that the structures in the abdominal and eyelid tissues were fundamentally different. In the abdominal skin, oxytalan fibres, which are rich in fibrillin-1, exhibiting a candelabra-like structure, were observed just below the basement membrane, as previously repo...
Source: Fight Aging! - June 20, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Living Skin Layer for Robots and Prostheses
Researchers at the University of Tokyo have developed a method to coat a robotic finger in a living “skin” layer. The living coating is strong and flexible enough to allow the robotic finger to bend and flex, and it can repel water and even self-heal if damaged.
The technique involves coating the robot in a “primer” layer of collagen and human dermal fibroblasts, which are two of the major components of the connective tissue within the skin. This layer naturally shrinks to conform with the robot surface. A second layer of human epidermal keratinocytes, which form the outer layer of skin, readily adh...
Source: Medgadget - June 15, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Rehab Source Type: blogs
Want your skin to look better? Then consider your mental health.
Despite a popular embrace of self-care and the growing awareness of trauma-like symptoms stemming from COVID, one facet of mental health remains widely overlooked: the way our emotional state affects our skin. Although most of us don ’t think about it regularly, our mental state impacts our bodies from head to toe, and the skin—the largest,Read more …Want your skin to look better? Then consider your mental health. originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 3, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/katlein-franca" rel="tag" data-wpel-link="internal" > Katlein Fran ça, MD, PhD < /a > < /span > Tags: Conditions Dermatology Psychiatry Source Type: blogs
A call to dismantle structural heteronormative care [PODCAST]
“The visit with my patient helped to change my perspective. I should not have made assumptions about her based on my implicit bias. I highly recommend the Harvard Implicit Bias tests as an exercise in introspection. We also need to share and reflect on our experiences — especially when we were clearly incompetent. There areRead more …A call to dismantle structural heteronormative care [PODCAST] originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 1, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/the-podcast-by-kevinmd" rel="tag" data-wpel-link="internal" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Dermatology Source Type: blogs
Preserving Patient Dignity (Formerly Patient Modesty) Volume 122
Discussion Blog)
Source: Bioethics Discussion Blog - May 30, 2022 Category: Medical Ethics Source Type: blogs
A call to dismantle structural heteronormative care
“That is a very heteronormative lens.” These words were uttered to me by a 23-year-old female patient as I explained i-PLEDGE and the steps she must complete to take oral isotretinoin. The visit started as fairly routine. A young female presented with a complaint of acne. I quickly appraised the patient on entering. She wasRead more …A call to dismantle structural heteronormative care originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 29, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/naila-russell" rel="tag" data-wpel-link="internal" > Naila Russell, DNP, FNP-BC < /a > < /span > Tags: Policy Dermatology Primary Care Source Type: blogs
Fight Aging! Newsletter, May 30th 2022
In conclusion, fisetin supplementation may be a novel strategy to target excess cellular senescence and thereby reduce mitochondrial ROS to improve NO-mediated endothelial function with aging.
Exercise Upregulates BDNF Expression to Promote Dopamine Release and Brain Function
https://www.fightaging.org/archives/2022/05/exercise-upregulates-bdnf-expression-to-promote-dopamine-release-and-brain-function/
Researchers have in the past shown that exercise results in greater amounts of BDNF, which in turn promotes neurogenesis. Here, this line of research is extended to show that exercise results in an increa...
Source: Fight Aging! - May 29, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Discussion of Progress Towards Reprogramming Therapies with a Turn.bio Co-Founder
The Lifespan.io team here talks with one of the co-founders of Turn.bio, one of the first biotech ventures focused on partial reprogramming as a basis for rejuvenation therapies. Their initial technology involves the delivery of lipid nanoparticles that encapsulate mRNA for temporary expression of the Yamanaka factors. Full reprogramming dedifferentiates and rejuvenates cells, turning somatic cells into induced pluripotent stem cells with youthful epigenetic patterns. Epigenetic rejuvenation is desirable, but producing pluripotent cells in the body is not. Partial reprogramming attempts to apply reprogramming factors for l...
Source: Fight Aging! - May 27, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
Naked Mole-Rat Skin Shows Fewer Signs of Aging
https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem ...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Naked Mole-Rat Skin Shows Fewer Signs of Aging
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem cell populations and regenerative capacity, as well as a near immunity to cancer. Accordingly, the research community is very interested in uncovering the genetic and biochemical differences that allow naked mole-rats to achieve these desirable outcomes.
In today's open access paper, the authors report on their investigation of the biochemistry a...
Source: Fight Aging! - May 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 16th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 15, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Decreased Ribosomal Biogenesis in Some Long-Lived Individuals
Ribosomes in a cell are where proteins are assembled according to a messenger RNA blueprint. Like all cellular components, ribosomes are regularly created and recycled. Reduced production of new ribosomes is a feature of calorie restriction, slowed aging accompanied by a lower output of new proteins. Further, genetic alterations that force a reduction in ribosomal biogenesis also modestly slow aging in animal studies, so it is thought that the pace of protein production is a relevant mechanism in the connection between cellular metabolism and aging. Researchers here extend this line of research into humans, looking at ribo...
Source: Fight Aging! - May 11, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Future Of Vision And Eye Care
3D printed digital contact lenses, bionic eye implants, augmented reality: the future of vision and eye care is full of science fiction-sounding innovations. Here is where digital health will take ophthalmology in the future!
More than 80 percent of perception comes through vision
Researchers estimate that 80-85 percent of our perception, learning, cognition, and activities are mediated through vision. Compared to that, our hearing only processes 11 percent of information, while smell 3.5 percent, touch 1.5 percent and taste 1 percent. Don’t you think that’s possible? Renowned scholars, L.D. Ros...
Source: The Medical Futurist - May 10, 2022 Category: Information Technology Authors: berci.mesko Tags: Augmented Reality Cyborgization 3d printing AI diabetes digital digital health future guide Healthcare Innovation Personalized medicine technology vision eye care ophthalmology Source Type: blogs
COVID-Related Skin Injuries
Thankfully the worst of the COVID-19 pandemic is over, but there is no doubt that the public health crisis brought new challenges to the wound care world. There has been profound impact upon caregivers and patients, including the epidemiology of skin lesions such as pressure injuries. The reverberations of the pandemic are still lingering, and this post will call attention to major concerns.
Impact of COVID-19 on Pressure Injury Epidemiology
The impact of SARS-CoV-2 on the occurrence of pressure injuries is substantial. Patients with severe respiratory disease and extended ICU admissions while on life support such as v...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - May 3, 2022 Category: Geriatrics Authors: Jeffrey M Levine Tags: Featured Medical Articles Geriatric Medicine Pressure Injuries & Wound Care bedsores coronavirus COVID COVID-19 decubiti decubitus ulcer Healthcare Quality Improving Medical Care pandemic pressure sore pressure sores pressure u Source Type: blogs
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
