Cancers, Vol. 14, Pages 4645: Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer
In this study, we showed that TAX inhibited the proliferation of cells by inducing S-phase cell cycle arrest and prevented cell migration by interfering epithelial-mesenchymal transition (EMT) in Lewis lung cancer (LLC) cells and lung carcinoma SPC-A1 cells. The pharmacological network analysis predicted that induction of apoptosis might be the potential mechanism of TAX-mediated cell deaths. Further in vitro experiments showed that TAX could significantly induce cancer cell apoptosis as verified by increased pro-apoptotic molecules including Bax, caspase-9, and PARP1 downregulated anti-apoptotic protein Bcl-2; and decreas...
Source: Cancers - September 24, 2022 Category: Cancer & Oncology Authors: Junjie Lu Bo Shuai Zhexing Shou Weina Guo Cong Zhou Xiaohu Ouyang Haifeng Zhou Junyi Li Jing Cui Feng Jiang Kim Yun Jin Alexey Sarapultsev Fangfei Li Ge Zhang Shanshan Luo Desheng Hu Tags: Article Source Type: research
Contamination of food crops by unintentionally released PCB 47, PCB 51 and PCB 68 in the vicinity of silicone production sites and their relevance for human health assessment
Chemosphere. 2022 Sep 9:136392. doi: 10.1016/j.chemosphere.2022.136392. Online ahead of print.ABSTRACTSince it was shown that silicone rubber production can unintentionally release PCBs, these production sites have become a focus of investigation. The use of the cross-linking agent bis(2,4)-dichlorobenzoylperoxide (2,4-DCBP) can lead to emissions of the PCB congeners PCB 47, PCB 51 and PCB 68 into the environment and cause their accumulation e. g. in food crops. To determine the presence and extent of this uptake, we used the newly developed method dandelion screening. Samples were taken from wild dandelion plants near nin...
Source: Chemosphere - September 12, 2022 Category: Chemistry Authors: Katja Hombrecher Ulrich Quass Silvia Sievering Angelika Sch öppe Knut Rauchfuss Source Type: research
Contamination of food crops by unintentionally released PCB 47, PCB 51 and PCB 68 in the vicinity of silicone production sites and their relevance for human health assessment
Chemosphere. 2022 Sep 9:136392. doi: 10.1016/j.chemosphere.2022.136392. Online ahead of print.ABSTRACTSince it was shown that silicone rubber production can unintentionally release PCBs, these production sites have become a focus of investigation. The use of the cross-linking agent bis(2,4)-dichlorobenzoylperoxide (2,4-DCBP) can lead to emissions of the PCB congeners PCB 47, PCB 51 and PCB 68 into the environment and cause their accumulation e. g. in food crops. To determine the presence and extent of this uptake, we used the newly developed method dandelion screening. Samples were taken from wild dandelion plants near nin...
Source: Chemosphere - September 12, 2022 Category: Chemistry Authors: Katja Hombrecher Ulrich Quass Silvia Sievering Angelika Sch öppe Knut Rauchfuss Source Type: research
Contamination of food crops by unintentionally released PCB 47, PCB 51 and PCB 68 in the vicinity of silicone production sites and their relevance for human health assessment
Chemosphere. 2022 Sep 9:136392. doi: 10.1016/j.chemosphere.2022.136392. Online ahead of print.ABSTRACTSince it was shown that silicone rubber production can unintentionally release PCBs, these production sites have become a focus of investigation. The use of the cross-linking agent bis(2,4)-dichlorobenzoylperoxide (2,4-DCBP) can lead to emissions of the PCB congeners PCB 47, PCB 51 and PCB 68 into the environment and cause their accumulation e. g. in food crops. To determine the presence and extent of this uptake, we used the newly developed method dandelion screening. Samples were taken from wild dandelion plants near nin...
Source: Chemosphere - September 12, 2022 Category: Chemistry Authors: Katja Hombrecher Ulrich Quass Silvia Sievering Angelika Sch öppe Knut Rauchfuss Source Type: research
Contamination of food crops by unintentionally released PCB 47, PCB 51 and PCB 68 in the vicinity of silicone production sites and their relevance for human health assessment
Chemosphere. 2022 Sep 9:136392. doi: 10.1016/j.chemosphere.2022.136392. Online ahead of print.ABSTRACTSince it was shown that silicone rubber production can unintentionally release PCBs, these production sites have become a focus of investigation. The use of the cross-linking agent bis(2,4)-dichlorobenzoylperoxide (2,4-DCBP) can lead to emissions of the PCB congeners PCB 47, PCB 51 and PCB 68 into the environment and cause their accumulation e. g. in food crops. To determine the presence and extent of this uptake, we used the newly developed method dandelion screening. Samples were taken from wild dandelion plants near nin...
Source: Chemosphere - September 12, 2022 Category: Chemistry Authors: Katja Hombrecher Ulrich Quass Silvia Sievering Angelika Sch öppe Knut Rauchfuss Source Type: research
Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/ β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model
CONCLUSIONS: PBMF had a significant inhibitory effect on recurrence and lung metastasis of GC. The potential mechanism may involve reversing EMT by inhabiting the Wnt/β-catenin signaling pathway. Lymphatic metastasis was also inhibited by PBMF via down-regulating the activation of the VEGF-C/D-VEGFR-2/3 signaling cascade.PMID:36056333 | DOI:10.1186/s12906-022-03703-0 (Source: Cancer Control)
Source: Cancer Control - September 2, 2022 Category: Cancer & Oncology Authors: Lin Tian Xuxi Chen Li Cao Lishi Zhang Jinyao Chen Source Type: research
Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/ β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model
CONCLUSIONS: PBMF had a significant inhibitory effect on recurrence and lung metastasis of GC. The potential mechanism may involve reversing EMT by inhabiting the Wnt/β-catenin signaling pathway. Lymphatic metastasis was also inhibited by PBMF via down-regulating the activation of the VEGF-C/D-VEGFR-2/3 signaling cascade.PMID:36056333 | DOI:10.1186/s12906-022-03703-0 (Source: Cancer Control)
Source: Cancer Control - September 2, 2022 Category: Cancer & Oncology Authors: Lin Tian Xuxi Chen Li Cao Lishi Zhang Jinyao Chen Source Type: research
Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/ β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model
The plant-based medicinal food (PBMF) is a functional compound extracted from 6 medicinal and edible plants: Coix seed, L. edodes, A. officinalis L., H. cordata, Dandelion, and G. frondosa. Our previous studies h... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - September 2, 2022 Category: Complementary Medicine Authors: Lin Tian, Xuxi Chen, Li Cao, Lishi Zhang and Jinyao Chen Tags: Research Source Type: research
Book Review: The Orchid and the Dandelion: Why Sensitive People Struggle and How All Can Thrive
No abstract available (Source: Journal of Developmental and Behavioral Pediatrics)
Source: Journal of Developmental and Behavioral Pediatrics - September 1, 2022 Category: Child Development Tags: Book Review Source Type: research
Protective Effect of Dandelion Leaf Water Extracts on APAP-Induced Liver Injury in Rats and Its Mechanism
Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):24-33. doi: 10.14715/cmb/2022.68.5.4.ABSTRACTwith the advent of a large number of drugs in recent years and the aggravation of human aging, drug-induced liver injury is increasing year by year. The protective effect of dandelion extract on acetaminophen (APAP) - induced drug-induced liver injury in rats and its specific mechanism was studied by in vitro cell culture. For this aim,twenty healthy SD rats with the same physiological status were divided into model group and normal group, with 10 rats in each group. The drug-induced liver injury model was made by intragastric ad...
Source: Mol Biol Cell - August 27, 2022 Category: Molecular Biology Authors: Liang Wang Lingyi Zhang Junyan Wang Juan Li Jie Ding Xiaodong He Source Type: research
Protective Effect of Dandelion Leaf Water Extracts on APAP-Induced Liver Injury in Rats and Its Mechanism
Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):24-33. doi: 10.14715/cmb/2022.68.5.4.ABSTRACTwith the advent of a large number of drugs in recent years and the aggravation of human aging, drug-induced liver injury is increasing year by year. The protective effect of dandelion extract on acetaminophen (APAP) - induced drug-induced liver injury in rats and its specific mechanism was studied by in vitro cell culture. For this aim,twenty healthy SD rats with the same physiological status were divided into model group and normal group, with 10 rats in each group. The drug-induced liver injury model was made by intragastric ad...
Source: Cellular and Molecular Biology - August 27, 2022 Category: Molecular Biology Authors: Liang Wang Lingyi Zhang Junyan Wang Juan Li Jie Ding Xiaodong He Source Type: research
