Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/ β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model

CONCLUSIONS: PBMF had a significant inhibitory effect on recurrence and lung metastasis of GC. The potential mechanism may involve reversing EMT by inhabiting the Wnt/β-catenin signaling pathway. Lymphatic metastasis was also inhibited by PBMF via down-regulating the activation of the VEGF-C/D-VEGFR-2/3 signaling cascade.PMID:36056333 | DOI:10.1186/s12906-022-03703-0
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research