In Horses, the Gut Microbiome Interacts with Mitochondria to Improve Function
The study here is carried out in horses, but it is reasonable to expect to find very similar mechanisms in other mammals. The beneficial populations of the gut microbiome provide metabolites that steer cell function and exist in symbiosis with the host animal. Mitochondria, the power plants of the cell, are the evolved descendants of ancient symbiotic microbes, now an integral part of cellular processes. It is reasonable to think that the one can influence the other directly via signaling processes, as researchers discuss in these materials and elsewhere. In humans, for example, researchers have found that propionate gener...
Source: Fight Aging! - April 14, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Michelin Star Medicine: Food Start-Up Epicured Delivers Meals for GI & Chronic Condition Care
By JESSICA DaMASSA, WTF HEALTH
Food-as-Medicine startup, Epicured, looks and acts a lot like the consumer meal delivery startups booming during this pandemic (think Freshly, which was just acquired by Nestle for $1.5B) but with one important difference: all the meals are based on diets that have been clinically validated as treatments for chronic disease. The three year old company got its start in GI disorders, turning complex Low FODMAP diets, gluten-free diets, etc. into home-delivered, ready-to-eat dishes that patients with Crohn’s disease, Colitis, IBS, IBD, celiac, or other gastro conditions could actually i...
Source: The Health Care Blog - December 8, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Jessica DaMassa WTF Health Epicured Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a p...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Interventions Targeting the Aging of the Gut Microbiome
Age-related changes to the microbial populations of the gut, the gut microbiome, appear important in the progression of aging. The effects on long-term health and risk of age-related conditions might be on a par with those of physical activity, and certainly overlap with those of diet. With ageing, beneficial microbes that produce metabolites (such as butyrate) that lead to better tissue function diminish in number, while harmful microbes that spur chronic inflammation grow in number. This may be due to loss of immune system competency, as the immune system gardens the gut microbiome, or it may be due to diminished intesti...
Source: Fight Aging! - October 19, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Early, tight control of Crohn ’s disease may have lasting benefits
The gastrointestinal (GI) tract is a remarkable organ: it resides on the inside of our bodies, but is regularly in contact with the outside world by virtue of what we ingest. It is quite incredible that the immune cells of the GI tract are not activated more regularly by the many foreign products it encounters every day. Only when the GI tract encounters an intruder that risks causing disease do the immune cells of the GI tract spring into action.
That is, of course, under normal circumstances. In people with Crohn’s disease, the normally tolerant immune cells of the GI tract are activated without provocation, and this a...
Source: Harvard Health Blog - October 16, 2020 Category: Consumer Health News Authors: Sarah Flier, MD Tags: Digestive Disorders Source Type: blogs
Case of the Week 604
This week ' s case was generously donated by Dr. Peter Gilligan, and features a histopathology section of an appendix from a patient with Crohn ' s disease. The pathologist was concerned when they saw the following object in the lumen of the appendix. Identification? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - August 31, 2020 Category: Parasitology Source Type: blogs
Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Organoids Used to Identify NRG1 as a Regulator of Tissue Repair in the Intestine
The intestinal lining is an important tissue. Among its other functions, it protects the body from inflammation that can be generated by the actions of gut microbes. This barrier declines with age, and this is thought to be influential in the increased chronic inflammation observed in older people. Ways to spur greater maintenance and repair on the part of cell populations making up intestinal tissue would likely be of great benefit, given the importance of chronic inflammation as a driver of age-related disease.
A strong cellular lining is essential for a healthy gut as it provides a barrier to the billions of mi...
Source: Fight Aging! - July 27, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Podcast: Should I Date Someone With Bipolar Disorder?
Can a relationship work when one person has severe mental illness? In today’s Not Crazy podcast, Gabe and Lisa discuss dating with bipolar disorder. They share their own story of dating, marrying and divorcing under the umbrella of Gabe’s bipolar diagnosis, and discuss the ups and downs from both perspectives.
What are some positive signs that the relationship can last? And what are the clues that you might need to call it quits? Tune in for a heartfelt discussion on living and dating with severe mental illness.
(Transcript Available Below)
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Source: World of Psychology - June 16, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Bipolar Disorders General Marriage and Divorce Not Crazy Podcast Relationships Source Type: blogs
11 Health ’s Free Virtual Support Platform for Chronic Digestive Disease Patients During COVID Pandemic: Interview with Michael Seres, Founder and CEO
11 Health, a medtech company based in the UK and California, has offered 12 weeks of free access to the Alfred SmartCare Platform, which allows for virtual peer and nursing support for patients with severe chronic digestive disorders, such as inflammatory bowel disease, Crohn’s disease, and colorectal cancer. The offer is the company’s response to the COVID-19 pandemic. The pandemic has meant that many patients are self-isolating and now have to focus more on managing their conditions at home.
Healthcare systems around the world are straining under the pressure of the COVID-19 pandemic. Not only are many hospitals ...
Source: Medgadget - April 27, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive GI Public Health Telemedicine Source Type: blogs
The Fantastic Autoimmune Beasts and Where to Find Them
Hairy, scary, funny looking or pretty cool. The beasts in the Harry Potter universe are quite the diverse bunch with unique abilities and qualities. Just like new digital health tech targeted to fight autoimmune diseases or for the main part: their symptoms.
Source: Warner Bros. Framestore
The common ground for completely different illnesses like type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis is an immune system disfunction. Immune cells and mechanisms target the body’s own cells and structures, deconstructing it bit by bit and inducing inflammation.
An estimated...
Source: The Medical Futurist - March 17, 2020 Category: Information Technology Authors: szandra Tags: Biotechnology Future of Medicine chatbot diabetes digital health sleep optimization chronic pain chronic illness skin coronavirus autoimmune disease Source Type: blogs
Fight Aging! Newsletter, December 30th 2019
This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts. BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence-associated β-galactosidase (SA-β-gal)-positive cell rates of late PD cells grown in the BBR-containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically, BBR im...
Source: Fight Aging! - December 29, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Genetic Variants are not an Important Risk Factor in the Vast Majority of People and Age-Related Conditions
This is an age of genetics, in which the costs of obtaining and working with genetic data have dropped by orders of magnitude, while the capabilities of the tools and technologies have expanded to a similar degree. Give the scientific community a hammer, and a great many parts of the field start to look like a nail. Thus there are innumerable studies of genetics and longevity, genetics and specific age-related diseases, and so forth. There is considerable interest in trying to find out whether there is a genetic contribution to survival to extreme old age, and then using this information to develop therapies.
What t...
Source: Fight Aging! - December 27, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 23rd 2019
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons.
Epige...
Source: Fight Aging! - December 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Immunization Against Flagellin as a Way to Beneficially Alter Aging Gut Microbiota Populations
The microbial populations of the gut make a significant contribution to health via secreted metabolites and interactions with the immune system. Starting in mid-life, these populations alter for the worse, and this is thought to influence the progression of aging - perhaps primarily as a contributing cause of chronic inflammation. How this effect size compares with those resulting from dietary and exercise choices is an open question, but it isn't unreasonable to suggest it to be in the same ballpark as exercise.
What can be done to improve this situation? Supplementation with metabolites produced in larger amounts ...
Source: Fight Aging! - December 18, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
