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Dietary supplements and bleeding
In conclusion, physicians must be aware of the potential anticoagulant effects of these supplements. It is imperative to report dietary and herbal supplement usage to physicians and is best to discontinue nonessential supplement use 2 weeks prior to surgery.PMID:36304597 | PMC:PMC9586694 | DOI:10.1080/08998280.2022.2121575 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - October 28, 2022 Category: Universities & Medical Training Authors: Jess Hatfield Saadeddine Saad Chad Housewright Source Type: research

Reduction in Rates of Symptomatic Urinary Tract Infection After Pelvic Reconstructive Surgery: A Quality Improvement Analysis
This study aimed to determine if a combination of interventions was successful at reducing the rate of postoperative symptomatic urinary tract infections (SUTIs) in a female pelvic medicine and reconstructive surgery (FPMRS) practice. Study Design Observational, retrospective quality improvement analysis looking at the rate of postoperative SUTI within 30 days of surgery in women who underwent gynecologic surgery performed by an FPMRS surgeon from October 2015 to October 2019. Symptomatic urinary tract infection was defined by symptoms and urinalysis, positive urine culture, or treatment for cystitis or urethritis w...
Source: Journal of Pelvic Medicine and Surgery - October 27, 2022 Category: Surgery Tags: Original Research Source Type: research

Cranberry and black chokeberry extracts isolated with pressurized ethanol from defatted by supercritical CO < sub > 2 < /sub > pomace inhibit colorectal carcinoma cells and increase global antioxidant response of meat products during in vitro digestion
We report antiproliferative properties of unique extracts, which were obtained from the defatted by supercritical CO2 cranberry (CrE) and black chokeberry (ChoE) pomace using pressurized ethanol, and global antioxidant response of meat products enriched with berry polyphenolics during in vitro digestion. ChoE was more effective against HCT116 and DLD1 cells than CrE, while the HCT116 cells were more sensitive to digested meat samples than DLD1. At 1000 μL ChoE reduced cell viability to 51% (HCT116) and ∼50% (DLD1), while in case of CrE >69% of HCT116 cells remained viable. The extracts added at 2% increased antioxida...
Source: Cell Research - October 4, 2022 Category: Cytology Authors: Laura Tamkut ė Gintar ė Jančiukė Milda Pukalskien ė Ieva Sarapinien ė Vytenis Arvydas Skeberdis Petras Rimantas Venskutonis Source Type: research

IJERPH, Vol. 19, Pages 11995: The Effects of Cranberry Polyphenol Extract (CPE) Supplementation on Astringency and Flavor Perception as a Function of PROP Taster Status and Other Individual Factors
This study investigated whether PROP (6-n-propylthiouracil) taster status and other individual factors (gender, ethnicity, BMI, and age) are markers of variation in perceptions of astringency and other flavor attributes. Participants (n = 125) evaluated cranberry juice cocktail samples (CJC) supplemented with cranberry-derived polyphenol extract (CPE, added at 0, 0.3, 0.5 and 0.75 g/L), as well as control samples, unsweetened cranberry juice (CJ) and an aqueous solution of 0.75 g/L CPE. Subjects evaluated samples for key sensory attributes and overall liking using a 15 cm line scale. The data were analyzed using ANCOVA and...
Source: International Journal of Environmental Research and Public Health - September 22, 2022 Category: Environmental Health Authors: Neeta Y. Yousaf Beverly J. Tepper Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5772: Cranberry Ingestion Modulated Drug Transporters and Metabolizing Enzymes: Gefitinib Used as a Probe Substrate in Rats
In conclusion, CJ ingestion affected the activities and protein levels of P-gp, BCRP, CYP3A4 and CYP2D6. (Source: Molecules)
Source: Molecules - September 6, 2022 Category: Chemistry Authors: Yu Tsai Li Hsu Lin Lee Chao Hou Tags: Article Source Type: research

Cranberry polyphenols and agave agavins impact gut immune response and microbiota composition while improving gut barrier function, inflammation, and glucose metabolism in mice fed an obesogenic diet
The consumption of plant-based bioactive compounds modulates the gut microbiota and interacts with the innate and adaptive immune responses associated with metabolic disorders. The present study aimed to evaluate the effect of cranberry polyphenols (CP), rich in flavonoids, and agavins (AG), a highly branched agave-derived neo-fructans, on cardiometabolic response, gut microbiota composition, metabolic endotoxemia, and mucosal immunomodulation of C57BL6 male mice fed an obesogenic high-fat and high-sucrose (HFHS) diet for 9 weeks. Interestingly, CP+AG-fed mice had improved glucose homeostasis. Oral supplementation with CP ...
Source: Frontiers in Immunology - August 16, 2022 Category: Allergy & Immunology Source Type: research

Assessment of ultrasound-assisted vacuum impregnation as a method for modifying cranberries' quality
Ultrason Sonochem. 2022 Aug 8;89:106117. doi: 10.1016/j.ultsonch.2022.106117. Online ahead of print.ABSTRACTCombined vacuum impregnation and ultrasound was proposed as an alternative method to improve the infusion of ascorbic acid in berry fruit. The effect of ultrasound application at different stages of impregnation - vacuum, relaxation, and both stages - on the qualitative characteristics of impregnated cranberries was investigated. The quality assessment was based on porosity, color, antioxidant capacity, anthocyanin, polyphenol and structure compound content. Ultrasound-assisted vacuum impregnation contributed to high...
Source: Ultrasonics Sonochemistry - August 14, 2022 Category: Chemistry Authors: Dominik Mierzwa Justyna Szadzi ńska Bartosz Gapi ński El żbieta Radziejewska-Kubzdela R óża Biegańska-Marecik Source Type: research

Expanding Arsenal against Neurodegenerative Diseases using Quercetin based Nanoformulations: Breakthroughs and Bottlenecks
Curr Neuropharmacol. 2022 Aug 10. doi: 10.2174/1570159X20666220810105421. Online ahead of print.ABSTRACTQuercetin (Qu), a dietary flavonoid, is obtained from many fruits and vegetables such as coriander, broccoli, capers, asparagus, onion, figs, radish leaves, cranberry, walnuts, and citrus fruits. It has proven its role as a nutraceutical owing to numerous pharmacological effects against various diseases in preclinical studies. Despite these facts, Qu and its nanoparticles are less explored in clinical research as a nutraceutical. The present review covers various neuroprotective actions of Qu against various neurodegener...
Source: Current Neuropharmacology - August 11, 2022 Category: Drugs & Pharmacology Authors: Sukriti Vishwas Rajesh Kumar Rubiya Khursheed Arya Kadukkattil Ramanunny Rajan Kumar Ankit Awasthi Leander Corrie Omji Porwal Mohammed F Arshad Mohammed Kanan Alshammari Abdulrahman A Alghitran Ashwaq N Qumayri Saif M Alkhaldi Abdulaziz Khalaf Alshammari Source Type: research

[Corrigendum] The cranberry flavonoids PAC DP ‑9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells
Int J Oncol. 2022 Oct;61(4):118. doi: 10.3892/ijo.2022.5408. Epub 2022 Aug 10.ABSTRACTFollowing the publication of this article, an interested reader drew to the author's attention that, in Fig. 5D on p. 1931, the two rightmost panels appeared to have been inverted for the SKOV3 cell line (i.e., the 'Q‑aglycone' and 'PAC DP‑9' data panels appeared to have been included in this figure the wrong way around). The authors checked the figure, and realized that these panels had indeed erroneously been inverted during the assembly of the figure. The corrected version of Fig. 5 is shown on the next page. The authors regret tha...
Source: International Journal of Oncology - August 10, 2022 Category: Cancer & Oncology Authors: Yifei Wang Alex Han Eva Chen Rakesh K Singh Clinton O Chichester Richard G Moore Ajay P Singh Nicholi Vorsa Source Type: research