Neurexin1 α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia
ConclusionDeletion of the neurexin1 α gene in rats causes exaggerated social play, which is not modified by social play deprivation. This phenotype therefore resembles disinhibited behaviour rather than the social withdrawal seen in ASD and SCZ. The neurexin1α knockout rat could be a model for inappropriate or disinhibited social be haviour seen in childhood mental disorders. (Source: Psychopharmacology)
Source: Psychopharmacology - February 29, 2024 Category: Psychiatry Source Type: research
AACAP Endorses the Inclusion of Methylphenidate in the WHO Model Lists of Essential Medicines
The World Health Organization (WHO) essential medicines list (EML) includes a list of minimum medicine needs for a basic health-care system, listing the most efficacious, safe, and cost-effective medicines for priority conditions. Priority conditions are selected on the basis of current and estimated future public health relevance, and potential for safe and cost-effective treatment. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - February 27, 2024 Category: Psychiatry Authors: Samuele Cortese, David Coghill, Gregory W. Mattingly, Luis Augusto Rohde, Robyn P. Thom, Timothy E. Wilens, Ian C.K. Wong, Stephen V. Faraone Tags: Letter to the Editor Source Type: research
Association of Age and Response to Methylphenidate HCL Treatment in Adult ADHD: A Proton Magnetic Resonance Spectroscopy Study
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - February 20, 2024 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Methylphenidate for Apathy in Alzheimer's Disease: Addressing Heterogeneity of Response, Safety Outcomes and Future Directions
Apathy is found in 24-85% patients with Alzheimer's disease (AD), making it the most common neuropsychiatric symptom (NPS) of AD. Apathy in AD is associated with faster disease progression, greater cognitive decline, increased caregiver distress and decreased quality of life, and hence is an important interventional target with no current approved treatments. The recent Apathy in Dementia Methylphenidate Trial 2 (ADMET 2), the largest randomized, double-blind, placebo-controlled, multi-center, phase III clinical trial that investigated the efficacy of methylphenidate for apathy in patients with mild to moderate AD, found t...
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Krista Lanct ôt, Paul Rosenberg, Jacobo Mintzer Source Type: research
Post-COVID central hypersomnia, a treatable trait in long COVID: 4 case reports
ConclusionWe highlight the importance of identifying cases of post-COVID central hypersomnia, as it may be a treatable trait of a post-COVID condition. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 14, 2024 Category: Neurology Source Type: research
Methylphenidate for treating fatigue in palliative cancer care - effect and side effects in real-world data from a palliative care unit
CONCLUSION: Methylphenidate is generally effective and well-tolerated for the treatment of CRF in palliative care. However, patients with a short life expectancy (<4 weeks) seem to benefit less from the treatment regardless of age, cancer type and dose.PMID:38348853 | DOI:10.2340/1651-226X.2024.24156 (Source: Acta Oncologica)
Source: Acta Oncologica - February 13, 2024 Category: Cancer & Oncology Authors: Agneta Almerud Gabriella Frisk Caritha Klasson Linda Bj örkhem-Bergman Source Type: research
Prevalence of the use of prescription stimulants as “study drugs” by UK university students: A brief report
ConclusionThere is a clear need for large-scale research in this area, using representative sampling and survey methods that protect student anonymity. (Source: Brain and Behavior)
Source: Brain and Behavior - February 13, 2024 Category: Neurology Authors: Ffinian Jones,
Philip M. Newton Tags: BRIEF REPORT Source Type: research
A review of recent treatments for adults living with attention-deficit/hyperactivity disorder
Conclusion: Pharmacological and non-pharmacological approaches, as well as neurostimulation or a blend of these approaches were acknowledged as the most effective recent modalities in the treatment of adult ADHD.Contribution: This review reported on the most current approaches to treat adult ADHD. This will facilitate a better understanding and informed decisions with regard to dealing with adult ADHD. (Source: South African Journal of Psychiatry)
Source: South African Journal of Psychiatry - February 7, 2024 Category: Psychiatry Authors: Candice Wakelin, Michele Willemse, Erica Munnik Source Type: research
Perceived cognitive performance in off ‐prescription users of modafinil and methylphenidate: an online survey
ConclusionThese findings suggest that at least some reported off-prescription users of modafinil and methylphenidate may be seeking to reduce the impact of self-perceived poorer performance, particularly in forms of cognition that are likely to impact on self-directed or self-motivated work. (Source: Brain and Behavior)
Source: Brain and Behavior - February 5, 2024 Category: Neurology Authors: Rachel D. Teodorini,
Nicola Rycroft,
James H. Smith ‐Spark Tags: ORIGINAL ARTICLE Source Type: research
Child and Parent Mindfulness-Based Training Versus Medication for Childhood ADHD: A Randomised Clinical Trial
ConclusionsOverall, although mindfulness alone might not be sufficient for some families, family mindfulness training in general can be considered a non-pharmacological alternative or addition in the treatment of childhood ADHD.Preregistrationhttps://onderzoekmetmensen.nl/nl/trial/22179, 11.10.2013. (Source: Mindfulness)
Source: Mindfulness - February 3, 2024 Category: Psychiatry & Psychology Source Type: research
