Quantitative analysis of drugs of abuse and cognitive enhancers in influent wastewater by means of two chromatographic methods
Two methods for qualitative and quantitative analysis of selected drugs of abuse and a cognitive enhancer in wastewater samples were successfully developed and validated. A two-column setup was necessary for the analysis of all analytes included in this method. Evaluation of proof-of-concept samples enabled quantification of several analytes in wastewater grab samples, allowing the method to be used for monitoring trends in the consumption of the included analytes in wastewater. AbstractSewage-based epidemiology using influent wastewater is used to estimate the consumption trends of (illicit) drugs over a short or long per...
Source: Drug Testing and Analysis - November 28, 2023 Category: Drugs & Pharmacology Authors: Fabian Frankenfeld,
Lea Wagmann,
Cathy M. Jacobs,
Markus R. Meyer Tags: RESEARCH ARTICLE Source Type: research
Efficacy of methylphenidate treatment in childhood myotonic dystrophy type 1 and comorbid attention deficit hyperactivity disorder: A case report using eye tracking assessment
We describe a case study of an eleven-year-old male patient with myotonic dystrophy type 1 and comorbid ADHD that was treated with methylphenidate in a twice daily regime (0.60 mg/kg/day). Positive effects on learning and cognition were reported by the parents and teachers. (Source: Brain and Development)
Source: Brain and Development - November 24, 2023 Category: Neurology Authors: Dirk J.J. Sweere, Jos G.M. Hendriksen, R. Jeroen Vermeulen, Sylvia Klinkenberg Tags: Case Report Source Type: research
Efficacy and Safety of Methylphenidate and Atomoxetine in Medication-Naive Children with Attention-Deficit Hyperactivity Disorder in a Real-World Setting
ConclusionsOverall, MPH was more effective and better tolerated than ATX. The incidence of AEs in children treated with MPH varied with age, and was higher in young children and lower in children over 10 years of age. (Source: Drugs in R&D)
Source: Drugs in R&D - November 20, 2023 Category: Drugs & Pharmacology Source Type: research
The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment
Molecular Psychiatry, Published online: 13 November 2023; doi:10.1038/s41380-023-02314-6The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - November 13, 2023 Category: Psychiatry Authors: Susu Qu Xiangyu Zhou Zhicheng Wang Yi Wei Han Zhou Xinshuang Zhang Qingjie Zhu Yanmin Wang Quanjun Yang Likun Jiang Yuan Ma Yuan Gao Lei Kong Li Zhang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice
Biomed Pharmacother. 2023 Nov 8;169:115860. doi: 10.1016/j.biopha.2023.115860. Online ahead of print.ABSTRACTIntracranial self-stimulation (ICSS) of the medial forebrain bundle in mice is an experimental model use to assess the relative potential of reward-seeking behaviors. Here, we used the ICSS model to evaluate the abuse potential of 18 abused drugs: 3-Fluoroethamphetamine (3-FEA); methylphenidate; cocaine; dextroamphetamine; alpha-Pyrrolidinobutyrophenone (α-PBT); 4'-Fluoro-4-methylaminorex (4-FPO); methamphetamine; larocaine; phentermine; paramethoxymethamphetamine (PMMA); phendimetrazine; N-(1-adamantyl)-1-pentyl-1...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 10, 2023 Category: Drugs & Pharmacology Authors: Yong-Qing Zhang Hyun Kyu Min Eunchong Hong Eunhye Yu Sun Mi Gu Seong Shoon Yoon Dohyun Lee Jaejun Lee Jin Tae Hong Jaesuk Yun Source Type: research
Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice
Biomed Pharmacother. 2023 Nov 8;169:115860. doi: 10.1016/j.biopha.2023.115860. Online ahead of print.ABSTRACTIntracranial self-stimulation (ICSS) of the medial forebrain bundle in mice is an experimental model use to assess the relative potential of reward-seeking behaviors. Here, we used the ICSS model to evaluate the abuse potential of 18 abused drugs: 3-Fluoroethamphetamine (3-FEA); methylphenidate; cocaine; dextroamphetamine; alpha-Pyrrolidinobutyrophenone (α-PBT); 4'-Fluoro-4-methylaminorex (4-FPO); methamphetamine; larocaine; phentermine; paramethoxymethamphetamine (PMMA); phendimetrazine; N-(1-adamantyl)-1-pentyl-1...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 10, 2023 Category: Drugs & Pharmacology Authors: Yong-Qing Zhang Hyun Kyu Min Eunchong Hong Eunhye Yu Sun Mi Gu Seong Shoon Yoon Dohyun Lee Jaejun Lee Jin Tae Hong Jaesuk Yun Source Type: research
A convolution ‐based in vitro‐in vivo correlation model for methylphenidate hydrochloride delayed‐release and extended‐release capsule
AbstractDelayed-release and extended-release methylphenidate hydrochloride (JORNAY PM ®) is a novel capsule formulation of methylphenidate hydrochloride, used to treat attention deficit hyperactivity disorder in patients 6 years and older. In this paper, we develop a Level A in vitro-in vivo correlation (IVIVC) model for extended-release methylphenidate hydrochloride to support p ost-approval manufacturing changes by evaluating a point-to-point correlation between the fraction of drug dissolved in vitro and the fraction of drug absorbed in vivo. Dissolution data from an in vitro study of three different release form...
Source: CPT: Pharmacometrics and Systems Pharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Pawan Kumar Gupta,
Bev Incledon,
Jogarao V. S. Gobburu,
Roberto Gomeni Tags: ARTICLE Source Type: research
