Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Protocol of a monocentric, double-blind, randomized, superiority, controlled trial evaluating the effect of in-prison OROS-methylphenidate vs. placebo treatment in detained people with attention-deficit hyperactivity disorder (BATIR)
Attention-deficit hyperactivity disorder (ADHD) is characterized by difficulty paying attention, poor impulse control, and hyperactive behavior. It is associated with several adverse health and social outcomes... (Source: Trials)
Source: Trials - January 4, 2024 Category: General Medicine Authors: St éphanie Baggio, Joël Billieux, Anja Dirkzwager, Katia Iglesias, Karine Moschetti, Nader Perroud, Marie Schneider, Nathalie Vernaz, Hans Wolff and Patrick Heller Tags: Study protocol Source Type: research
Comparison of neuroprotective effects of a topiramate-loaded biocomposite based on mesoporous silica nanoparticles with pure topiramate against methylphenidate-induced neurodegeneration
CONCLUSION: TPM-loaded nanoparticles could be used as neuroprotective agents against MPH-induced neurodegeneration by improving seizure parameters and reducing inflammatory, oxidant, and apoptotic factors.PMID:38170306 | DOI:10.1007/s11033-023-09011-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 3, 2024 Category: Molecular Biology Authors: Erfan Pari Mohammad Sheibani Mohammad Reza Sazegar Saeedeh Mir Ashrafsadat Moazam Mina Khalilzadeh Manijeh Motevalian Source Type: research
Comparison of neuroprotective effects of a topiramate-loaded biocomposite based on mesoporous silica nanoparticles with pure topiramate against methylphenidate-induced neurodegeneration
CONCLUSION: TPM-loaded nanoparticles could be used as neuroprotective agents against MPH-induced neurodegeneration by improving seizure parameters and reducing inflammatory, oxidant, and apoptotic factors.PMID:38170306 | DOI:10.1007/s11033-023-09011-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 3, 2024 Category: Molecular Biology Authors: Erfan Pari Mohammad Sheibani Mohammad Reza Sazegar Saeedeh Mir Ashrafsadat Moazam Mina Khalilzadeh Manijeh Motevalian Source Type: research
Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task
ConclusionsNL3R451C mice demonstrated intact attention orienting but altered responses to the pharmacological manipulation of the dopaminergic and noradrenergic networks. These findings expand our understanding of the NL3R451C mutation by suggesting that this mutation may lead to selective alterations in attentional processes. (Source: Psychopharmacology)
Source: Psychopharmacology - January 3, 2024 Category: Psychiatry Source Type: research
Methylphenidate attenuates signs of evoked neuropathic pain in animal model
Physiol Res. 2023 Dec 29;72(S5):S551-S558.ABSTRACTMethylphenidate is a psychostimulant that increases dopamine and noradrenaline levels. Recent studies have shown that methylphenidate potentiates the effect of morphine and together suppress acute and chronic pain. In clinical practice, methylphenidate has been used as a treatment for ADHD and changes of pain threshold have been noted in these patients. The aim of this study was to determine the effect of methylphenidate in an animal model of peripheral neuropathic pain. Neuropathic pain was modeled by the chronic constriction of the sciatic nerve (CCI) in Wistar rats. We e...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: K Panu šková L Vod ěrová Š Vaculín Source Type: research
Methylphenidate attenuates signs of evoked neuropathic pain in animal model
Physiol Res. 2023 Dec 29;72(S5):S551-S558.ABSTRACTMethylphenidate is a psychostimulant that increases dopamine and noradrenaline levels. Recent studies have shown that methylphenidate potentiates the effect of morphine and together suppress acute and chronic pain. In clinical practice, methylphenidate has been used as a treatment for ADHD and changes of pain threshold have been noted in these patients. The aim of this study was to determine the effect of methylphenidate in an animal model of peripheral neuropathic pain. Neuropathic pain was modeled by the chronic constriction of the sciatic nerve (CCI) in Wistar rats. We e...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: K Panu šková L Vod ěrová Š Vaculín Source Type: research
Methylphenidate attenuates signs of evoked neuropathic pain in animal model
Physiol Res. 2023 Dec 29;72(S5):S551-S558.ABSTRACTMethylphenidate is a psychostimulant that increases dopamine and noradrenaline levels. Recent studies have shown that methylphenidate potentiates the effect of morphine and together suppress acute and chronic pain. In clinical practice, methylphenidate has been used as a treatment for ADHD and changes of pain threshold have been noted in these patients. The aim of this study was to determine the effect of methylphenidate in an animal model of peripheral neuropathic pain. Neuropathic pain was modeled by the chronic constriction of the sciatic nerve (CCI) in Wistar rats. We e...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: K Panu šková L Vod ěrová Š Vaculín Source Type: research
Methylphenidate attenuates signs of evoked neuropathic pain in animal model
Physiol Res. 2023 Dec 29;72(S5):S551-S558.ABSTRACTMethylphenidate is a psychostimulant that increases dopamine and noradrenaline levels. Recent studies have shown that methylphenidate potentiates the effect of morphine and together suppress acute and chronic pain. In clinical practice, methylphenidate has been used as a treatment for ADHD and changes of pain threshold have been noted in these patients. The aim of this study was to determine the effect of methylphenidate in an animal model of peripheral neuropathic pain. Neuropathic pain was modeled by the chronic constriction of the sciatic nerve (CCI) in Wistar rats. We e...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: K Panu šková L Vod ěrová Š Vaculín Source Type: research
Pharmacokinetics of Long-Acting Methylphenidate: Formulation Differences, Bioequivalence, Interchangeability
ConclusionAdditional pharmacokinetic parameters and consistency in guidelines across the regulatory bodies may improve bioequivalence assessments. Based on our findings, more research is also required to understand whether bioequivalence is an appropriate measure for determining MPH interchangeability. This critical review is suitable for formulation scientists, clinical pharmacologists, and clinicians. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - December 21, 2023 Category: Drugs & Pharmacology Source Type: research
Pharmacotherapy for ADHD in children and adolescents: A summary and overview of different European guidelines
Conclusion: Pharmacological treatment options for ADHD in children and adolescents are effective and generally well-tolerated. Pharmacotherapy for ADHD is always part of a multimodal approach. While there is a considerable consensus among European guidelines on pharmacotherapy for ADHD, notable differences exist, particularly concerning the selection and sequencing of various medications.What is Known:• There is a significant base of evidence for pharmacological treatment for ADHD in children and adolescents.• Pediatricians are often involved in assessment, diagnosis and management of children with ADHD.What is N...
Source: European Journal of Pediatrics - December 14, 2023 Category: Pediatrics Source Type: research
Methylphenidate with or without fluoxetine triggers reinstatement of cocaine seeking behavior in rats
Neuropsychopharmacology, Published online: 12 December 2023; doi:10.1038/s41386-023-01777-zMethylphenidate with or without fluoxetine triggers reinstatement of cocaine seeking behavior in rats (Source: Neuropsychopharmacology)
Source: Neuropsychopharmacology - December 12, 2023 Category: Neurology Authors: Lorissa Lamoureux Joel Beverley Heinz Steiner Michela Marinelli Source Type: research
