Fight Aging! Newsletter, December 10th 2018
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging.
Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes
https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/
Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the co...
Source: Fight Aging! - December 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Epigenetic Signature that Matches the Majority of Cancers
Real progress in the defeat of cancer will emerge from mechanisms that are common to near all cancers. Given a signature, or a required mechanism, that appears universally in cancer, then it should be possible to craft a single form of treatment that can be applied to any cancer type. That the enormous and massively funded cancer research community has struggled to make progress towards the control of cancer in the present environment of revolutionary progress in the tools of biotechnology largely results from spending too much time and too many resources on technologies that are only narrowly applicable to certain types o...
Source: Fight Aging! - December 6, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Artificial Intelligence Automatically Spots Polyps During Colonoscopies (Interview)
Artificial intelligence is making big strides in a variety of medical fields, including radiology, oncology, and even ophthalmology. Now a company called Wision AI, based in Shanghai, Cina, is adapting artificial intelligence vision software to help doctors spot polyps during a colonoscopy. The technology is meant for real-time use and the procedure itself doesn’t change much from existing colonoscopies.
We spoke with JingJia Liu, Cofounder and CEO of Wision AI about the company technology, how it works, and what it is capable of already.
Medgadget: Can you briefly describe your company’s technology and ...
Source: Medgadget - December 4, 2018 Category: Medical Devices Authors: Editors Tags: Exclusive GI Informatics Surgery Source Type: blogs
I Got My Whole Genome Sequenced. Here ’s What I Learned.
Dante Labs sent me their Full DNA whole genome sequencing package, and I went through a roller-coaster of feelings: I was excited to know every secret of my cells, but I was afraid to get to know my hereditary cancer risks and worried what I might find. As in my case, (scientific) curiosity usually overrides fear, I jumped into the unknown and I’m eager to share my results here.
Whole genome sequencing is available to anyone. So what?
The human genome is the blueprint for building a person. When the Human Genome Project was completed in 2006, and the DNA double spiral uncovered its secrets for the very first time, scient...
Source: The Medical Futurist - November 20, 2018 Category: Information Technology Authors: nora Tags: Biotechnology Genomics Medical Professionals Patients Personalized Medicine Policy Makers Dante Labs data DNA future genetic genome sequencing genomic data genomic testing Health health risks health science Healthcare I Source Type: blogs
Fight Aging! Newsletter, November 19th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - November 18, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Popular Science View of Checkpoint Inhibitor Cancer Immunotherapies
Checkpoint inhibitor therapies are a demonstrably successful approach to cancer immunotherapy. They suppress a mechanism that normally restrains immune cells from attacking other cells. This mechanism is abused by cancers, alongside a variety of other ways in which the immune system can be subverted or quieted. Any advanced tumor tends to have evolved into a state in which it is ignored or even helped by the immune system. Checkpoint inhibitor therapies are an improvement on chemotherapy when it comes to the trade-off between harming the cancer and harming the patient, as well as in the odds of success, but still present r...
Source: Fight Aging! - November 13, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 5th 2018
In conclusion, weight cycling significantly increased life-span relative to remaining with obesity and had a similar benefit to sustained modest weight loss.
Support for Oxidized Cholesterol as a Primary Cause of Atherosclerosis
https://www.fightaging.org/archives/2018/11/support-for-oxidized-cholesterol-as-a-primary-cause-of-atherosclerosis/
In the paper I'll point out today, the authors provide evidence in support of the concept that it is specifically oxidized cholesterol that is the primary cause of atherosclerosis rather than the condition resulting from too much cholesterol in general. In atherosc...
Source: Fight Aging! - November 4, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Where Does Blood Testing Stand Today?
The dream about a drop of blood signaling a wide range of diagnostic results was shattered with Elizabeth Holmes and the Theranos scam. The machination of the company has set back the innovation of blood testing and investment into the field for years. However, there’s always hope. The Medical Futurist looked around where blood testing stands today and what’s the future it is heading towards.
Dreaming about a home laboratory
Stephen just came home from walking his dog, Barney, an always smiling labrador. The 40-something got off his smart shoes, sat back on the yellow couch that he and her partner, Sara, were fighting ...
Source: The Medical Futurist - November 3, 2018 Category: Information Technology Authors: nora Tags: Biotechnology Business Future of Medicine Medical Professionals Patients Portable Diagnostics Researchers blood blood draw blood test blood testing digital health health market home Innovation laboratory theranos Source Type: blogs
Recent Research into the Interaction of Exercise and Aging
Today's open access papers touch on aspects of the interaction between exercise and the pace of aging. People age at somewhat different rates, and for the vast majority of us lifestyle is a far greater determinant of that rate than our genes. Until such time as the clinical deployment of rejuvenation therapies is well underway, and in regions of the world sufficiently wealthy to have tamed the majority of infectious disease, it remains the case that our choices regarding our health, such as calorie restriction and exercise, are the most reliable means of improving life expectancy. The size of the effect is not enormous in ...
Source: Fight Aging! - November 2, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What happened to the grasshoppers?
When I was a kid, grasshoppers were everywhere. I walked through a field every day to get to school and grasshoppers were everywhere, jumping back and forth across my path, frequently banging off my legs. At night in summer, the backyard was filled with fireflies that we’d chase and capture in jars to watch up close. And there were butterflies of many colors and varieties everywhere, flitting from flower to flower.
Today, I don’t see any grasshoppers. In fact, I haven’t seen one in over 40 years. I saw one—just one—firefly this past summer in my backyard. And I can count the number of butterie...
Source: Wheat Belly Blog - October 22, 2018 Category: Cardiology Authors: Dr. Davis Tags: Agribusiness bowel flora Inflammation microbiota prebiotic probiotic wheat belly Source Type: blogs
A man in his 80s with chest pain
Written by Pendell MeyersA male in his 80s with history of colon cancer, HTN, and CAD with a newly placed LAD stent approximately 1 month ago, presenting with acute shortness of breath and chest pain. No prior ECG.Here is his ECG at 07:08:There is STE in V2, I and aVL, but it does not meet STEMI criteria because there are no two contiguous leads with STE meeting criteria. There is also STD in V3-V6, as well as II, III, and aVF. There is likely lead misplacement involving V2 explaining the R-wave progression. These findings and their associated morphology are definite evidence of transmural ischemia of the anterior and late...
Source: Dr. Smith's ECG Blog - October 22, 2018 Category: Cardiology Authors: Pendell Source Type: blogs
Unexpected Lessons Learned From the Wheat Belly Lifestyle
In the seven years since the original Wheat Belly book hit bookstores and turned the nutritional world topsy-turvy and millions of people have engaged in a grain-free lifestyle, many unique lessons have been learned.
Even though I had engaged the practices of this lifestyle for a number of years and in thousands of people before I broadcast these ideas through books, expanding the audience to many more people yielded feedback on an enormous scale, new lessons that even surprised me.
Among the new lessons learned along the way:
Plantar fasciitis—I did not expect to have so many people report that this painful condition t...
Source: Wheat Belly Blog - October 17, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates bowel flora gluten gluten-free grain-free grains Inflammation Weight Loss Source Type: blogs
When diagnosing colon cancer isn ’t in a patient’s best interest
So much of life depends upon timing. Sure, we plan, but we know how much of our life’s events are unplanned and unexpected. So often, our jobs and our mates — two of our most defining accomplishments — are the result of a chance encounter or a random act. Life does not reliably proceed in an orderly manner.
This is often true in the medical profession. Here, physicians in our quest to seek out and squelch disease, often discover what would should have been left alone. For example, is discovering prostate cancer in an older man a true benefit if the tumor would have remained silent throughout the man’s life?...
Source: Kevin, M.D. - Medical Weblog - October 15, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/michael-kirsch" rel="tag" > Michael Kirsch, MD < /a > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
Fight Aging! Newsletter, October 15th 2018
This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy.
Replacement of Aged Microglia Partially Reverses Cognitive Decline in Mice
https://www.fightaging.org/archives/2018/10/replacement-of-aged-microglia-partially-reverses-cognitive-decline-in-mice/
Researchers here report on a compelling demonstration that shows the degree to which dysfunctional microglia contribute to age-related neurodegeneration. The scientists use a pharmacological approach to greatly deplete the microglial population and then allow it to recover naturally. Th...
Source: Fight Aging! - October 14, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Few More Reasons Not to Become Overweight and Obese
Being obese or overweight is, for the overwhelming majority of such individuals, a choice. There is plenty of ink spilled over how hard or easy the choice of body weight is to make, but it is nonetheless a choice. Want to weigh less? Then persist in eating fewer calories in the context of a sanely balanced diet. It really is as simple as that. The only way to fail is to fail to eat fewer calories. That this is eternally a challenge, and that obesity is increasingly prevalent in an environment of cheap calories, tells us more about human nature than it does about our biology.
The present consensus on the effects of e...
Source: Fight Aging! - October 11, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
