HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People
An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise from HDL level, chronological age, and smoking. The largest single cause of death in our species is atherosclerosis, a progressive malfunction in clearance of cholesterol from blood vessel walls that leads to fatty plaques, narrowed arteries, stroke, and heart attack. HDL particles carry excess cholesterol from blood vessel walls back to the liver for excretion, and - thus over a lifetime - the more HDL in circulation one has, the greater the...
Source: Fight Aging! - October 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Health and Mortality, Do Human Genetic Variants Matter More With Age Or Less With Age?
To what degree do genetic variants drive the observed differences in human life expectancy? The old consensus guesstimate was that environment determines 75% of life expectancy, and genetic variants the other 25%. Further, it is the common wisdom that gene variants become more important to life expectancy in later life, either by providing greater resilience to specific forms of damage and dysfunction, or slowing the pace at which that damage and dysfunction accumulates. A great deal of medical research is based on the insight that gene variants are thought to provide on disease processes.
Views on genetic variants ...
Source: Fight Aging! - October 14, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting the Gut Microbiome to Treat Aging
The distribution of microbial populations making up the gut microbiome changes with age in ways that are harmful to health, causing a reduction in production of beneficial metabolites and an increase in chronic inflammation. Animal studies make it clear that some approaches to restoring a more youthful gut microbiome, such as fecal microbiota transplantation from young donors, can produce a sustained rejuvenation of the gut microbiome and consequent improvement in later life health. Given the comparatively simplicity of this approach, and that the state of the gut microbiome can accurately measured via low-cost assays, thi...
Source: Fight Aging! - October 3, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Weekly Overseas Health IT Links –24th September, 2022.
This article makes the case and explains what will be required to make it happen.We hear a lot about “digital health” these days. As data about our health piles up — thanks to sources like electronic health records, personal fitness apps and gadgets, and home genome test kits — weshould understand a lot more than we used to about what ’s wrong with our health and what to do about it. But having a lot of data is not enough. We have to be aware of what we have, understand what it means, and act on that understanding. While the challenges are in some ways more acute in the United States because of its fragmented sys...
Source: Australian Health Information Technology - September 24, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
I ’ m a doctor who just had his first colonoscopy in my 60s — without anesthesia
Well, I am that family physician and geriatrician who is now almost 70 years old. And I cannot believe it because, in some ways, I am still like 27 years old! First of all, I’m very healthy, and I’m lucky that nobody in my family had colon cancer or any cancer. Most of my relatives
Read more…
I’m a doctor who just had his first colonoscopy in my 60s — without anesthesia originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 23, 2022 Category: General Medicine Authors: Mike Neskovic, MD Tags: Conditions Gastroenterology Source Type: blogs
The Complicated Prostate: Cancer Is a Concern but There's More to Consider
Most younger men don’t spend a lot of time considering the health of their prostate. However, around the age of 50, they’ll likely find that their physicians want to check out prostate health both physically and through blood work known as a prostate-specific antigen (PSA) test. The PSA is not a perfect test, but it’s still used to help detect prostate cancer since there aren’t many alternatives.
National Prostate Cancer Awareness Month is meant to increase the knowledge about possible prostate problems and make certain that men get checked out regularly.
What is the prostate?
The prostate is a small organ locat...
Source: Minding Our Elders - September 7, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Weekly Overseas Health IT Links – 23rd July2022.
In this study, researchers sought to determine whether differences in occult hypoxemia treatment existed between people of different races.Occult hypoxemia was defined as arterial blood oxygen saturation of less than 88 percent despite a pulse oximetry reading of 92 percent or more.-----https://healthitsecurity.com/news/security-awareness-and-training-crucial-to-preventing-healthcare-phishing-attacksSecurity Awareness and Training Crucial to Preventing Healthcare Phishing AttacksSecurity awareness and training greatly decreased the likelihood of an employee falling for a healthcare phishing attack, KnowBe4 researchers foun...
Source: Australian Health Information Technology - July 23, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
AI Adoption in Healthcare Requires Better Approaches to Patient Data
The following is a guest article by Vanessa Braunstein, Healthcare Product Marketing Lead at NVIDIA.
Building great AI models in healthcare and life sciences requires lots of data that is diverse, well-labeled, and spans across different patient types.
However, as AI gains traction, there are still a number of bottlenecks that slow down the process of developing robust AI models such as patient privacy, access to data, and lack of clinical expertise to annotate data for training.
In order to overcome these barriers, data scientists and developers have developed new solutions such as federated learning paradigms, AI models ...
Source: EMR and HIPAA - June 28, 2022 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Federated Learning GDPR Health Data Ethics Health Data Privacy Healthcare AI Healthcare AI Ethics Healthcare Neural Source Type: blogs
How IoT Medical Devices Save and Improve Lives
The following is a guest article by Erik Kling, Interim Head of IoT Americas at Vodafone Business.
IoT, or the Internet of Things, has transformed our homes with connected lights and smart appliances. It’s also revolutionized all areas of business, including manufacturing. Sensors connected to the internet can track goods throughout the supply chain — from sourcing materials to delivering completed products to consumers.
IoT technology has improved the way we live, but its most profound impact may be in healthcare, where it’s saving lives and improving health.
Before IoT revolutionized healthcare, doctors and care pr...
Source: EMR and HIPAA - June 23, 2022 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Clinical Health IT Company Healthcare IT IT Infrastructure and Dev Ops AED American College of Cardiology Connected Defibrillators Continuous Glucose Monitors CPAP Dr. Ami Bhatt Elliot Erik Kling Healthcare AI Source Type: blogs
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
June 09, 2022 Edition-----The Russian war on Ukraine is now well over 100 days old. The destruction and deaths are just awful and the world is being seriously re-shaped. Where this ends is unknowable but unlikely to be good.In the US we are seeing almost daily mass shootings and no-one seems to know what to do. Just pathetic.In the UK the hangover is slowly lifting after the 4 day royal celebration.In OZ we are having an energy crisis which we hope we will find solutions for soon!-----Major Issues.------https://www.theaustralian.com.au/business/economics/australias-labor-government-faces-a-whole-new-economic-ball-game/news...
Source: Australian Health Information Technology - June 9, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
Naked Mole-Rat Skin Shows Fewer Signs of Aging
https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem ...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 16th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 15, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Few Evident Relationships Between Accelerated Epigenetic Aging and Cancer
Epigenetic clocks are produced by identifying characteristic shifts in epigenetic marks with age, the decorations on the genome that control gene expression. It remains unclear as to the exact relationship between specific epigenetic marks and the underlying damage and dysfunction of aging, and so it remains unknown as to how comprehensively epigenetic clocks reflect the processes of aging: do all of the processes of aging contribute, or only some of them? If the latter, it will be hard to use epigenetic clocks to assess the quality of potential rejuvenation therapies. Removing that uncertainty will require a great deal of...
Source: Fight Aging! - May 11, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
