Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bacteria Promote Cancer Metastasis
Given the onset of a particular type of cancer, why does that cancer become a much worse prospect for only some individuals? Why are some people more prone to metastasis, for example? A perhaps underappreciated factor is the interaction of infectious agents with the tumor microenvironment, as researchers discuss here. Exposure to pathogens, and particularly persistent pathogens, may be a good explanation for many areas of medicine in which only some people bearing all of the traditional risk factors go on to develop the worst outcomes.
Microbes play a critical role in affecting cancer susceptibility and tumor prog...
Source: Fight Aging! - April 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Are my coping skills a result of my emergency medicine training?
In the wake of a harrowing year, I ’m left wondering, is a career in emergency medicine worth it? Like so many of my colleagues, I suffered personal tragedies during the pandemic that exacerbated the incredible stress at work. My brother died in March of 2021, three weeks after receiving a diagnosis of metastatic colon cancer,Read more …Are my coping skills a result of my emergency medicine training? originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 10, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/adrienne-van-curen" rel="tag" > Adrienne Van Curen, MD < /a > < /span > Tags: Physician Emergency Medicine Source Type: blogs
Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aging of the Intestinal Barrier as a Driving Cause of Chronic Inflammation
Chronic inflammation is a feature of aging, and causes disruption of cell and tissue function throughout the body. Short term inflammation is a necessary feature of regeneration from injury and defense against pathogens, but when inflammatory signaling is maintained for the long term it becomes very harmful. The risk of suffering all of the common diseases of aging is strongly connected to raised inflammation. Given this, we might ask what causes age-related systemic inflammation, and thus where should the research community seek to intervene, in order to reverse this undesirable aspect of degenerative aging.
A grow...
Source: Fight Aging! - March 29, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Cell-Loaded Beads Release Cytokines to Eradicate Tumors
In this study, we demonstrated that the ‘drug factories’ allow regulatable local administration of interleukin-2 and eradication of tumor in several mouse models, which is very exciting. This provides a strong rationale for clinical testing.”
This new technology aims to provide localized immunotherapy in the form of beads that act as “drug factories,” constantly pumping out a cytokine. The beads consist of ARPE-19 cells that are encapsulated in a polymer shell. The polymer coating protects the cells from the worst ravages of the foreign body response, but keeps them in place and allows the secreted...
Source: Medgadget - March 21, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology Source Type: blogs
10 colorectal pearls for Colorectal Cancer Awareness Month
March is Colorectal Cancer Awareness Month. Share these gems with your family, friends, and patients. Take the time to reflect on your personal history and encourage yourself and others to get screened when appropriate. 1. The large intestine or the large bowel consists of the colon, rectum, and anus. The colon and rectum have aRead more …10 colorectal pearls for Colorectal Cancer Awareness Month originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 18, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/maseray-s-kamara" rel="tag" > Maseray S. Kamara, MD < /a > < /span > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Many Mediocre Cancer Therapies Become Much Better When More Targeted to Cancerous Tissues
One of the important areas of cancer research and development that appears to receive a great deal of attention and funding, but in practice seems slow to make it from the laboratory to the clinic, is the targeting of therapeutics to cancerous cells. Reductio ad absurdum, near any of dozens of existing chemotherapeutics would do the job of completely clearing tumors, with minimal to no side-effects, if one could only find a way to delivery tiny amounts of the therapeutic to every cancer cell while avoiding every healthy cell. The inability to target treatments this effectively is exactly why cancer remains such a problem. ...
Source: Fight Aging! - March 9, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Muscle Strengthening Activities in Later Life Correlate with Reduced Mortality
Past studies have demonstrated reduced mortality as a result of strength training in older individuals. Muscle tissue is metabolically active, involved in a range of processes in the body, such as insulin metabolism and control of inflammation. Here this review paper, researchers note the correlation between activities that strengthen muscle and lower mortality in epidemiological data. It is worth thinking about for those of us tempted to let the exercise schedule lapse as life moves on.
Physical inactivity is a global public health problem. Regular engagement in muscle-strengthening activities (eg, resistance tra...
Source: Fight Aging! - March 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Join the Undoctored Boot Camp January 5th to the 14th
Undoctored, as its name suggests, puts personal control over health back in your hands. We continue many of the strategies of the Wheat Belly lifestyle but expand them with lessons learned through this worldwide experience, while adding new dimensions and practices.
The Undoctored Wild, Naked, and Unwashed program causes you to revert back to the way humans were supposed to be eating and living all along to mimic the behavior and health of primitive people who have virtually no modern diseases such as diabetes, colon cancer, and obesity (still lived to old age if they did not succumb to injury or infection). Learn:
How...
Source: Wheat Belly Blog - December 22, 2021 Category: Cardiology Authors: April Duval Tags: Open Undoctored Source Type: blogs
Join Dr. Davis ’ Infinite Health Boot Camp January 5th to the 14th
Undoctored is now Dr. Davis Infinite Health (www.DrDavisInfiniteHealth that goes live in early January) as its name suggests, puts personal control over health back in your hands. We continue many of the strategies of the Wheat Belly lifestyle but expand them with lessons learned through this worldwide experience, while adding new dimensions and practices. While we make the transition to Dr. Davis Infinite Health and away from Undoctored, the concepts and practices remain the same.
The Dr. Davis’ Wild, Naked, and Unwashed program causes you to revert back to the way humans were supposed to be eating and living all ...
Source: Wheat Belly Blog - December 22, 2021 Category: Cardiology Authors: April Duval Tags: Open Undoctored Source Type: blogs
Food Intolerances: A Warning of Bad Things Ahead
I’ve recently discussed how the majority of food intolerances, whether to FODMAPs, histamine, nightshades, fructose, etc., are really manifestations of dysbiosis and SIBO. Here is another way to view these phenomena: Food intolerances are your body’s signal to you that serious deterioration in your health is coming.
In other words, if all you do is choose to reduce or eliminate the offending food, you are still left with the massive disruption of your intestinal microbiome that caused the food intolerance in the first place, along with increased intestinal permeability and endotoxemia. So say you eliminate ferm...
Source: Wheat Belly Blog - November 1, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open microbiota prebiotic probiotic sibo small intestinal bacterial super gut undoctored wheat belly Source Type: blogs
Gastroenterology Embraces Artificial Intelligence
AI and machine learning have the potential to redefine the management of several GI disorders.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.Colonoscopy is one of the true success stories in modern medicine.Studies have demonstrated that colonoscopy screening detects the cancer at a much earlier stage, reducing the risk of invasive tumors and metastatic disease, andreducing mortality. However, while colorectal cancer is highly preventable, it is thethird leading cause of cancer-related deathsin the U.S. A...
Source: Life as a Healthcare CIO - October 13, 2021 Category: Information Technology Source Type: blogs
