What happened to the grasshoppers?

When I was a kid, grasshoppers were everywhere. I walked through a field every day to get to school and grasshoppers were everywhere, jumping back and forth across my path, frequently banging off my legs. At night in summer, the backyard was filled with fireflies that we’d chase and capture in jars to watch up close. And there were butterflies of many colors and varieties everywhere, flitting from flower to flower. Today, I don’t see any grasshoppers. In fact, I haven’t seen one in over 40 years. I saw one—just one—firefly this past summer in my backyard. And I can count the number of butteries I’ve seen in the past year on two fingers. We have managed to massively alter our external environment with widespread use of herbicides, pesticides, and other factors, sufficient to wipe out huge populations of creatures that used to be plentiful. Just as we have messed up our external environments, so we have also dramatically distorted our internal environments, specifically our microbiome. Given the many factors that distort the composition of the human microbiome, such as prescription antibiotics, antibiotic residues in meats, acid-blocking drugs, sugar consumption, synthetic sweeteners like aspartame, synthetic emulsifying agents like polysorbate 80, etc., we have changed the species and number of microbes inhabiting our intestines, skin, mouths, sinuses, airways, vaginas, and other areas. As a reflection of how far adrift we’ve come from...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Agribusiness bowel flora Inflammation microbiota prebiotic probiotic wheat belly Source Type: blogs

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Publication date: May 2020Source: Clinica Chimica Acta, Volume 504Author(s): Damian Jacenik, Jakub FichnaAbstractChemerin is a multifunctional protein involved among others in adipogenesis, angiogenesis and lipid as well as glucose metabolism. Chemerin is an essential factor in promotion of chemotaxis of numerous immune cell types and plays an important role in several pathophysiologic conditions. Chemerin receptors are present on monocytes/macrophages, T cells, natural killer and dendritic cells as well as neutrophils. However, the role of chemerin and chemerin receptors in immune response and gastrointestinal diseases is...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 17 February 2020Source: LWTAuthor(s): Min Gong, Zhilei Zhou, Yongjian Yu, Shuangping Liu, Shenghu Zhu, Dongzhen Jian, Pengjing Cui, Fang Zhong, Jian MaoAbstractAs an acidic system, Chinese traditional vinegar is rich in amino acids and sugars for the readily formation of 5-hydroxymethylfurfural (HMF) and furfural (F). The levels of HMF and F in Chinese vinegars from different regions were analyzed and discussed. F ranged from 4.35 to 313.95 mg/L, with an average value of 136.71 mg/L, while the mean level of HMF was 103.69 mg/L (26.83–455.13 mg/L). A significant positive corr...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 17 February 2020Source: LWTAuthor(s): Jennifer V. Félix-Medina, Julio Montes-Ávila, Cuauhtémoc Reyes-Moreno, J. Xiomara K. Perales-Sánchez, Mario A. Gómez-Favela, Ernesto Aguilar-Palazuelos, Roberto Gutiérrez-DoradoAbstractSnacks directly expanded (second-generation) are trendy in the market, but considered products of poor nutritional due to usually made with corn starch. In this research, optimization of the extrusion process variables and the bean flour inclusion level was carried out to develop optimized expanded snacks (OES) with high nutriti...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
The objective of the present study was to develop a method for labeling lamb meat and goat milk by selective enrichment of terbium and thulium in the feed for the animals. Therefore, a distinctive rare earth element (REE) pattern is artificially introduced which can be determined in food products. Detection of REE labels was carried out using inductively coupled plasma mass spectrometry (ICP-MS) after acid digestion. Alternatively, laser ablation ICP-MS (LA-ICP-MS) was applied, allowing direct analysis of bone samples and analysis of meat and milk samples after dry ashing and pressing pellets.After three weeks of administe...
Source: Food Research International - Category: Food Science Source Type: research
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
Publication date: Available online 16 February 2020Source: Biosensors and BioelectronicsAuthor(s): Khalil K. Hussain, N.G. Gurudatt, Mahmood H. Akthar, Kyeong-Deok Seo, Deog-Su Park, Yoon-Bo ShimAbstractA robust amperometric sensor was developed for the lactate detection in the extracellular matrix of cancer cells. The sensor was fabricated by separately immobilizing nicotinamide adenine dinucleotide (NAD+) onto a carboxylic acid group and lactate dehydrogenase (LDH) onto an amine group of bi-functionalized conducting polymer (poly 3-(((2,2':5′,2″-terthiophen)-3′-yl)-5-aminobenzoic acid (pTTABA)) composit...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 17 February 2020Source: Journal of Molecular BiologyAuthor(s): Jens Danielsson, Jeffrey Kenneth Noel, Jennifer Michelle Simien, Brendan Michael Duggan, Mikael Oliveberg, José Nelson Onuchic, Patricia Ann Jennings, Ellinor HaglundAbstractLeptin is an important signaling hormone, mostly known for its role in energy expenditure and satiety. Furthermore, leptin plays a major role in other proteinopathies such as cancer, marked hyperphagia, impaired immune function, and inflammation. Despite its biological relevance in human health, there are no NMR resonance assignments of the human pr...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 17 February 2020Source: Life SciencesAuthor(s): Luiz Antonio Lupi, Maira Smaniotto Cucielo, Henrique Spaulonci Silveira, Letícia Barbosa Gaiotte, Roberta Carvalho Cesário, Fábio Rodrigues Ferreira Seiva, Luiz Gustavo de Almeida ChuffaAbstractToll-like receptors (TLRs) are critical sensors related to inflammation and tumorigenesis. Among all subtypes, the TLR4 is a highly described transmembrane protein involved in the inflammatory process. The TLR4/myeloid differentiation factor 88 (MyD88) signaling pathway has been implicated in oncogenic events in several tissues an...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 February 2020Source: Inorganica Chimica ActaAuthor(s): Priyaranjan Kumar, Ray J. Butcher, Ashis K. PatraAbstractHerein, we report physiochemical aspects, crystal structures, biological reactivity and interaction, DNA damage activity and preliminary antimicrobial properties of three metal complexes, [Co/Ni(dppz)2(sac)(H2O)]ClO4 [Co(II), 1; Ni(II), 2] and [Cu(dppz)2(sac)]ClO4 (3), where dppz is dipyrido[3,2-a:2′,3′-c]phenazine as potential photosensitizer and DNA intercalator and sac is artificial sweetener saccharin (o-sulfobenzimide). The solid-state structural analysis rev...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
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