Extracellular vesicles in the Chronic Myeloid Leukemia scenario: an update about the shuttling of disease markers and therapeutic molecules
Extracellular vesicles (EVs) are various sets of cell-derived membranous structures containing lipids, nucleic acids, and proteins secreted by both eukaryotic and prokaryotic cells. It is now well recognized that EVs are key intercellular communication mediators, allowing the functional transfer of bioactive chemicals from one cell to another in both healthy and pathological pathways. It is evident that the condition of the producer cells heavily influences the composition of EVs. Hence, phenotypic changes in the parent cells are mirrored in the design of the secreted EVs. As a result, EVs have been investigated for a wide...
Source: Frontiers in Oncology - January 8, 2024 Category: Cancer & Oncology Source Type: research
Maximizing the Value of Chronic Myeloid Leukemia Management Using Tyrosine Kinase Inhibitors in the USA: Potential Determinants and Consequences of Healthcare Resource Utilization and Costs, with Proposed Optimization Approaches
ConclusionsHealthcare resource utilization and costs of chronic myeloid leukemia care may be considered barometers of ineffective management, including mutation-driven tyrosine kinase inhibitor resistance and switching as well as non-adherence and intolerance. Future prospective research is warranted to help determine whether costs can be reduced and other treatment outcomes optimized via more proactive and effective diagnostic interventions (i.e., regular molecular monitoring and proactive mutational testing) and treatment approaches. The strengths and limitations of this review include its emphasis on observational resea...
Source: Clinical Drug Investigation - January 5, 2024 Category: Drugs & Pharmacology Source Type: research
Bilateral Sudden Irreversible Hearing Loss in a Case of Chronic Myeloid Leukaemia: A Case Report
AbstractChronic myeloid leukemia is a type of blood cancer that affects the bone marrow and results in an overproduction of immature WBCs. The genetic mutation that causes CML is the BCR-ABL fusion gene. Adolescents are rarely affected. The case study aims to discuss a rare case of chronic myeloid leukemia causing bilateral hearing impairment, tinnitus, and vertigo. A 30-year-old female presented to the hospital in November, 2021, with sudden hearing impairment and other symptoms, leading to a CML diagnosis. Blood tests revealed hyperleukocytosis with marked neutrophilia, mild basophilia, and eosinophilia, and a BCR-ABL qu...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - January 4, 2024 Category: ENT & OMF Source Type: research
AS1041, a novel derivative of marine natural compound Aspergiolide A, induces senescence of leukemia cells via oxidative stress-induced DNA damage and BCR-ABL degradation
In this study, we reported anthraquinone lactone AS1041, a synthesized derivative of marine natural compound Aspergiolide A, showed anti-leukemia effect in vitro and in vivo by promoting cell senescence. Mechanistic study revealed the pro-senescence effect of AS1041 was dependent on oxidative stress-induced DNA damage, and the resultant activation of P53/P21 and P16INK4a/Rb. Also, AS1041 promoted ubiquitin proteasome system (UPS)-mediated BCR-ABL degradation, which also contributed to AS1041-induced senescence. In vivo, AS1041-induced senescence promoted tumor growth inhibition. In summary, the in vitro and in vivo antitum...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 3, 2024 Category: Drugs & Pharmacology Authors: Xuxiu Lu Fengli Yuan Liang Qiao Yankai Liu Qianqun Gu Xin Qi Jing Li Dehai Li Ming Liu Source Type: research
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR
This study showed that the inhibition of AchE expression by indirubin plays a key role in the occurrence of adverse reactions to indirubin and that the underlying mechanism is related to AhR-mediated AchE downregulation.PMID:38164702 | DOI:10.1080/00498254.2023.2297745 (Source: Xenobiotica)
Source: Xenobiotica - January 2, 2024 Category: Research Authors: Xiaoting Xu Reham Taha Chenghan Chu Li Xiao Tao Wang Xinzhi Wang Xin Huang Zhenzhou Jiang Lixin Sun Source Type: research
Indirubin mediates adverse intestinal reactions in guinea pigs by downregulating the expression of AchE through AhR
This study showed that the inhibition of AchE expression by indirubin plays a key role in the occurrence of adverse reactions to indirubin and that the underlying mechanism is related to AhR-mediated AchE downregulation.PMID:38164702 | DOI:10.1080/00498254.2023.2297745 (Source: Xenobiotica)
Source: Xenobiotica - January 2, 2024 Category: Research Authors: Xiaoting Xu Reham Taha Chenghan Chu Li Xiao Tao Wang Xinzhi Wang Xin Huang Zhenzhou Jiang Lixin Sun Source Type: research
A case of central venous catheter-related Candida parapsilosis fungemia evolved to disseminated infection in a neutropenic patient with blast crisis of chronic myeloid leukemia.
Central venous catheter-related infections are of particular importance in onco-hematological patients.Candidaparapsilosis is generally reported as a mild pathogen, however it is able to effectively colonize intravascular devices and potentially give rise to sustained fungemias. Here we report a case of invasive, potentially lethalC. parapsilosis disseminated infection in a neutropenic patient affected by chronic myeloid leukemia with blast crisis. We underline the importance of removing the central venous catheter as potential source of infection as soon as possible during the course of candidemia, and not replacing it wi...
Source: Mediterranean Journal of Hematology and Infectious Diseases - January 1, 2024 Category: Hematology Authors: Elena Amabile, Matteo Totaro, Luca Cappelli, Clara Minotti, Alessandra Micozzi Source Type: research
GSE104384 Lineage-Specific TOP2A Cleavage Landscape in Leukemia Cell
Contributors : Xiang Yu ; James W Davenport ; Carolyn A Felix ; Brian D GregorySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTopoisomerases II (TOP2) play role in relief of torsional stress during DNA replication and gene transcription, and TOP2 is also a target of anticancer agents which cause secondary leukemia. To address cell lineage-specific TOP2A cleavage relative to leukemia, here we profile genome-wide TOP2A cleavage in human acute lymphoblastic leukemia (ALL) cell line CEM, and compare to TOP2A cleavage landscape of chronic myelogenous leukemia (CML) cell lin...
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Epigenetic Modulation of DDIT3 and MGMT Expression Acts Synergistically with Resistance to Imatinib towards CML Disease Progression: A Hospital based Study
CONCLUSION: In the present study notable depletion of survivality was established in the Imatinib resistance patients manifesting genetic malfunction of BCR-ABL transcripts among the North East Indian inhabitants and advocating for the expansion of the disease.PMID:38156838 | DOI:10.31557/APJCP.2023.24.12.4059 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 29, 2023 Category: Cancer & Oncology Authors: Gautam Hazarika Manash Jyoti Kalita Simanta Kalita Partha Pratim Das Kalpajit Dutta Lipika Lahkar Anjanjyoti Rajkonwar Mohammed Ghaznavi Idris Vinotsale Khamo Giriraj Kusre Subhash Medhi Source Type: research
Second Treatment-Free Remission Attempt in Patients with Chronic Myeloid Leukemia
Long-term survival outcomes of patients with chronic myeloid leukemia in the chronic phase (CML-CP) are now similar to those of the general population, following the introduction of ABL1 tyrosine kinase inhibitors (TKIs). Approximately 40 –80% of patients with CML successfully achieved treatment-free remission after the first attempt of TKI discontinuation (TFR1), after achieving a durable deep molecular response (DMR). However, the possibility of achieving treatment-free remission after a second attempt of TKI discontinuation (TFR 2) remains unclear. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - December 28, 2023 Category: Hematology Authors: Hiroshi Ureshino, Kazuharu Kamachi, Shinya Kimura Tags: Review Article Source Type: research
SOHO State of the Art Updates and Next Questions: Chronic Myeloid Leukemia and Pregnancy: "Per Aspera Ad Astra"
Clin Lymphoma Myeloma Leuk. 2023 Dec 12:S2152-2650(23)02189-4. doi: 10.1016/j.clml.2023.11.011. Online ahead of print.ABSTRACTChronic myeloid leukemia (CML) has evolved from an invariably fatal disease to a chronic disorder that can be treated with targeted drugs and allows survival expectations approaching age-matched controls. Thus, pregnancy and conception in CML should not be precluded anymore; however, to ensure the well-being of both the mother and the developing fetus careful planning and management are required. Tyrosine Kinase Inhibitors (TKIs) are not genotoxic or carcinogenic but can pose a risk to the developin...
Source: Clinical Lymphoma and Myeloma - December 27, 2023 Category: Cancer & Oncology Authors: Elisabetta Abruzzese Malgorzata Monika Trawinska Paolo De Fabritiis Simona Bernardi Source Type: research
