Fight Aging! Newsletter, April 19th 2021
In conclusion, airway pressure treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce risk of subsequent dementia. (Source: Fight Aging!)
Source: Fight Aging! - April 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
COVID-19 Data Shows the Importance of Thymic Atrophy in Aging
The decline of the immune system is of great importance in aging. Vulnerability to infection, a decreased surveillance of senescent cells and cancerous cells, and growing chronic inflammation all take their toll. A sizable fraction of this problem stems from the diminished supply of new T cells of the adaptive immune system. T cells begin life as thymocytes in the bone marrow, then migrate to the thymus where they mature. Unfortunately, the thymus atrophies with age, a process known as thymic involution, in which active tissue is replaced by fat. The T cell supply falters, and as a result the existing T cell population bec...
Source: Fight Aging! - April 15, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others.
A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration
https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/
The nervous system of mammals is poorly regenerative at best. The use of implantable scaffold materials is one of th...
Source: Fight Aging! - October 18, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Using CRISPR to Remove Mutated Sequences of Nuclear DNA Required by Cancerous Cells
Fusion genes feature in many cancers, a form of mutation in which two genes are joined together, such as through deletion of the DNA sequences that normally separate the two genes. The resulting mutant fusion gene sequence encodes a fusion protein that can have novel effects, or in which both portions remain functional, but are now produced in at inappropriate times and in inappropriate amounts. This change in cell biochemistry can be important in driving cancerous behavior, and this appears to be the case in a meaningful fraction of cancer types.
Today's research materials discuss a clever use of CRISPR DNA editing...
Source: Fight Aging! - October 16, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
“When Blood Breaks Down”: It Can Break Your Heart
By CHADI NABHAN, MD, MBA, FACP
“The goal for me and for my clinical and research colleagues is to put ourselves out of a job as quickly as possible”. This is how Mikkael Sekeres ends his book “When Blood Breaks Down” based on true stories of patients with leukemia. I share Mikkael’s sentiments and have always stated that I’d be happy if I am out of a job caring for patients with cancer. To his and my disappointment, this wish is unlikely to ever come true, especially when dealing with leukemia.
With almost 15 years of experience, Sekeres possesses a wealth of knowledge and patient stories making him t...
Source: The Health Care Blog - July 2, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Book Review Chadi Nabhan hematology Mikkael Sekeres Oncology When Blood Breaks Down Source Type: blogs
Fight Aging! Newsletter, June 8th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 7, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reuse of a Small Molecule to Increase Autophagy in the Brain is Trialed for Alzheimer's Disease
Today I'll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn't made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of...
Source: Fight Aging! - June 5, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What Does an Ideal Healthcare System Look Like?
By ASHISH JHA, MD
Austin Frakt and Aaron Carroll recently approached me about a New York Times UpShot piece aiming to rank eight healthcare systems they had chosen: Australia, Canada, France, Germany, Singapore, Switzerland, the United Kingdom, and the United States. This forced me to think about a pretty fundamental question: what do we want from a healthcare system?
I would argue that most people want a healthcare system where they can get timely access to high quality, affordable care and one that also promotes innovation of new tests and treatments. But underlying these sentiments are a lot of important issues that nee...
Source: The Health Care Blog - September 20, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
The BCRA Is An Improvement Over Obamacare. Here ’ s why..
ANISH KOKA MD
Dr. Jha writes on these pages in typically stirring fashion about his views on the recent health care kerfuffle and rightly so fingers what the real focus of our efforts should be: Cost. He ends by slaying both sides because of their refusal to confront the hospital chargemonster – the fee schedule hospitals make that remarkably only really applies to the uninsured.
Unfortunately, the solution proposed ensures hospital fee schedules for the uninsured are no greater than Medicare reimbursements, which is far from perfect. Consider that the Medicare reimbursement for a stent placed to an ischemic limb is ...
Source: The Health Care Blog - July 10, 2017 Category: Consumer Health News Authors: anish_koka Tags: Economics Repeal Replace Uncategorized Anish Koka BCRA Obamacare Source Type: blogs
Op-Ed in The Hill on Allowing Medicare to Directly Negotiate Drug Prices
Conclusion
There is no denying that Medicare and other government-funded programs are facing a serious funding crisis and that changes to the programs are long overdue. However, it is important to review history and not make the same mistakes that have already been made in attempting to resolve the issue. Instead, Dr. Fonseca believes that “Medicare beneficiaries should have more freedom to choose the coverage and services that best meet their individual needs and preferences.”
Related StoriesCMS Releases Report on Drug RebatesMedPAC Considers Revised Approaches to Part B Drug P...
Source: Policy and Medicine - March 16, 2017 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Health Affairs ’ September Issue: Payment Reforms, Prescription Drugs, And More
The September issue of Health Affairs, a variety issue, includes a number of studies examining aspects of payment reform, the impact of certain ACA provisions, the value of some high-cost anticancer drugs, and more. It also includes a DataGraphic examining aging and health.
DATAWATCH: New evidence of rapid physician practice consolidation, 2013–15
In the past few decades, group physician practices have become more of the norm, and the proportion of physicians in larger groups has grown. David Muhlestein and Nathan Smith, with Leavitt Partners in Salt Lake City, Utah, looked at Medicare’s Physician Compare data for the ...
Source: Health Affairs Blog - September 7, 2016 Category: Health Management Authors: Lucy Larner Tags: Elsewhere@ Health Affairs Featured Health Affairs journal Source Type: blogs
Cancer and the Politics of Moonshots
By ANEES CHAGPAR, MD
As many of the Republican and Democratic presidential candidates lament the high cost of healthcare and put forth how they aim to make it more cost effective, few have focused on the impact of out-of-pocket costs specifically for cancer patients. They should. One in every two men and one in every three women will get cancer at some point over their lifetime. As the U.S. population and American lifespans increase, this toll will have major financial ramification for everyone.
When fighting against the disease, cancer patients are often at the mercy of the pharmaceutical industry. Given Pfizer’s ...
Source: The Health Care Blog - February 28, 2016 Category: Consumer Health News Authors: John Irvine Tags: THCB Anees Chagar Source Type: blogs
The Health Care Question We Need to Be Asking the Candidates
By ANEES CHAGAR, MD
As many of the Republican and Democratic presidential candidates lament the high cost of healthcare and put forth how they aim to make it more cost effective, few have focused on the impact of out-of-pocket costs specifically for cancer patients. They should. One in every two men and one in every three women will get cancer at some point over their lifetime. As the U.S. population and American lifespans increase, this toll will have major financial ramification for everyone.
When fighting against the disease, cancer patients are often at the mercy of the pharmaceutical industry. Given Pfizer’s r...
Source: The Health Care Blog - February 28, 2016 Category: Consumer Health News Authors: John Irvine Tags: THCB Anees Chagar Source Type: blogs
To Spur Medical Innovation, Make Corporate Cheaters Pay
The past decade has seen a relatively constant rate of newly approved drugs every year. The number has even jumped in the past few years. Yet, despite such encouraging trends, we are actually facing a crisis in drug innovation today. That is because many of these new products do not offer substantial improvements over already available alternatives.
At the same time, novel and effective treatments for many diseases---both rare and common---remain elusive. For example, there is widespread concern over the lack of development of new antibiotics aimed at multidrug-resistant infections. Therapeutic innovation for central nerv...
Source: Health Affairs Blog - April 30, 2015 Category: Health Management Authors: Aaron Kesselheim Tags: Drugs and Medical Technology Health Policy Lab Medicaid and CHIP Medicare corporations Cost FDA legislation Marketing medical innovation Medical Innovation Act NIH Pharma price Source Type: blogs
PhRMA Innovation Hub Highlights Research and Advances in the Biopharmaceutical Industry
This article outlines the current human and economic impact that cancer imposes on the U.S. and the progress that is being made toward fighting cancer and understanding the value of its therapies.
Chronic Leukemias: Survival Rates Rise: The 5-year survival rate for chronic myeloid leukemia (CML) patients has increased dramatically since imatinib was first approved for treatment in 2001.
Pipeline of Hope: Learn about the discovery and development process of life-saving or life-enhancing medicines, from initial research to delivery.
Great Moments in Treatment Innovation highlights the key advances that have changed medicine ...
Source: Policy and Medicine - September 10, 2014 Category: American Health Authors: Thomas Sullivan Source Type: blogs
