Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry
Leukemia. 2024 Mar 28. doi: 10.1038/s41375-024-02204-y. Online ahead of print.ABSTRACTBlast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected hetero...
Source: Hamostaseologie - March 29, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hele Source Type: research
Leukemia cutis revealing relapse of a chronic myeloid leukemia: A case report
We present a case of a leukemia cutis revealing a relapse of a CML successfully treated by tyrosine kinase inhibitor. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 28, 2024 Category: General Medicine Authors: Amine Ch érif,
Mohammad Yassine Chérif,
Anne‐Laure Trépant,
Anne‐Pascale Meert,
Maxime Ilzkovitz Tags: CASE REPORT Source Type: research
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry
Leukemia, Published online: 28 March 2024; doi:10.1038/s41375-024-02204-yManagement and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry (Source: Leukemia)
Source: Leukemia - March 28, 2024 Category: Hematology Authors: Annamaria Brioli Elza Lomaia Christian Fabisch Tomasz Sacha Hana Klamova Elena Morozova Aleksandra Golos Philipp Ernst Ulla Olsson-Stromberg Daniela Zackova Franck E. Nicolini Han Bao Fausto Castagnetti Elzbieta Patkowska Jiri Mayer Klaus Hirschb ühl Hel Source Type: research
A chronic myeloid leukemia present with an unusual relapse in central nervous system: A case report
Blast cell in CSF examination. Key Clinical MessageExtramedullary involvement of the central nervous system (CNS) in Chronic Myeloid Leukemia (CML) is an uncommon relapse. In this case, we present a unique instance of a 43-year-old male diagnosed with CML experiencing a CNS blast crisis. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 27, 2024 Category: General Medicine Authors: Mais Musleh,
Qossay Alhussien Tags: CASE REPORT Source Type: research
Imatinib pharmacokinetics and creatine kinase levels in chronic myeloid leukemia patients: implications for therapeutic response and monitoring
ConclusionThe study highlights the link between imatinib ’s pharmacokinetics and elevated CK levels, indicating a possible correlation between specific metabolites and improved treatment response. Individualized monitoring of CK levels and imatinib pharmacokinetics could enhance care for CML patients. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Source Type: research
Are there new relevant therapeutic endpoints in the modern era of the BCR::ABL1 tyrosine kinase inhibitors in chronic myeloid leukemia?
Leukemia, Published online: 26 March 2024; doi:10.1038/s41375-024-02229-3Are there new relevant therapeutic endpoints in the modern era of the BCR::ABL1 tyrosine kinase inhibitors in chronic myeloid leukemia? (Source: Leukemia)
Source: Leukemia - March 26, 2024 Category: Hematology Authors: Hagop Kantarjian Susan Branford Massimo Breccia Jorge Cortes Fadi G. Haddad Andreas Hochhaus Timothy Hughes Ghayas C. Issa Elias Jabbour Franck E. Nicolini Koji Sasaki Francois Xavier-Mahon Source Type: research
