Detecting biological contaminants in water & pharmaceuticals  Spheryx
Spheryx, Inc., a small business funded by the National Science Foundation (NSF), created a technology to monitor, count and characterize microscopic particles in a variety of fluids, such as water, chemicals, or even pharmaceuticals.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - May 31, 2018 Category: Science Source Type: video
Regulating Autoimmunity and Autoinflammation: Cytokine blockade and beyond
Immunonology IG Seminar
Richard Siegel's interest in immunology and apoptosis began in the late 1980's at the University of Pennsylvania School of Medicine where he was an M.D., Ph.D. student. Working with Mark Greene and John Reed, he studied the influence of bcl-2 on T cell apoptosis and repertoire selection. He trained in Internal Medicine and Rheumatology at Hospital of the University of Pennsylvania, and moved to the NIH in 1996 to do postdoctoral training with Michael Lenardo in the Laboratory of Immunology in the National Institute of Allergy and Infectious Disease. There he studied apoptosis signaling and the molec...
Source: Videocast - All Events - May 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
ICCVAM Public Forum
ICCVAM ’ s goals include promotion of national and international partnerships between governmental and nongovernmental groups, including academia, industry, advocacy groups, and other key stakeholders. To foster these partnerships ICCVAM holds annual public forums to share information and facilitate direct communication of ideas and suggestions from stakeholders. This year ’ s meeting will include presentations by NICEATM and ICCVAM members on current activities related to the development and validation of alternative test methods and approaches, including activities relevant to implementation of the strategic roadmap ...
Source: Videocast - All Events - May 16, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Researchers are discovering an environmentally sustainable polymer that could replace plastics
In recent years, environmentally friendly materials to replace plastics have become a focus for chemists, and the discovery of a new polymer by Colorado State University could be just what they've been looking for. The material has the same characteristics of plastics that we enjoy -- for example, ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - May 11, 2018 Category: Science Source Type: video
Understanding the Combined Effects of Environmental Chemical and Non-Chemical Stressors: Atherosclerosis as a Model Workshop
AGENDA:For more information go tohttps://www.niehs.nih.gov/news/webcastsAir date: 4/12/2018 10:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - April 3, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
First-of-its-kind chemical oscillator
Researchers have created a DNA-only chemical oscillator by building DNA molecules that follow specific instructions. This systematic method has the potential to embed sophisticated circuit computation within molecular systems designed for applications in health care, advanced materials and ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - March 21, 2018 Category: Science Source Type: video
Biowulf Seminar: Precise genome-wide mapping of single nucleosomes and linkers in vivo
Biowulf Seminar Series
We developed a chemical cleavage method that allows us to precisely map
both single nucleosomes and linkers with very high accuracy genome-wide
in budding yeast. We confirm that /S. cerevisiae/ promoters are sites of
strong nucleosome depletion, but attribute the putative nucleosome
depletion seen at termination sites to MNase bias. Our nucleosome
mapping data has the highest resolution among the currently available
techniques, and this accuracy allows us to distinguish alternative
rotational positions that nucleosomes occupy in different cells.
Furthermore, we show that linker DNA has quanti...
Source: Videocast - All Events - March 13, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Predictive Models for Acute Oral Systemic Toxicity (Day 2)
The development of test methods that reduce or replace animal use for acute toxicity tests required by regulatory authorities is one of ICCVAM ’ s high priority activities. To this end, the ICCVAM Acute Toxicity Workgroup, with support from NICEATM, sponsored a global project to develop in silico models of acute oral systemic toxicity that predict five specific endpoints identified by member regulatory agencies. These endpoints included identification of “ very toxic ” chemicals (LD50 less than 50 mg/kg), “ nontoxic ” chemicals (LD50 greater than or equal to 2000 mg/kg), point estimates for LD50s, and categorizat...
Source: Videocast - All Events - March 8, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Predictive Models for Acute Oral Systemic Toxicity (Day 1)
The development of test methods that reduce or replace animal use for acute toxicity tests required by regulatory authorities is one of ICCVAM ’ s high priority activities. To this end, the ICCVAM Acute Toxicity Workgroup, with support from NICEATM, sponsored a global project to develop in silico models of acute oral systemic toxicity that predict five specific endpoints identified by member regulatory agencies. These endpoints included identification of “ very toxic ” chemicals (LD50 less than 50 mg/kg), “ nontoxic ” chemicals (LD50 greater than or equal to 2000 mg/kg), point estimates for LD50s, and categorizat...
Source: Videocast - All Events - March 8, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Argentine ants' chemical " weapons " make them pesky predators in California and the southern U.S.
Researchers at University of California, Riverside, have confirmed that Argentine ants, aggressive ants which thrive in California urban areas, utilize chemical secretions as weapons against harvester ants, which are native to California. This advancement in knowledge could lead to chemicals to ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - February 23, 2018 Category: Science Source Type: video
RNA Methylation in Gene Expression Regulation
NCI's Center for Cancer Research (CCR) Grand Rounds
Chuan He, Ph.D., is the John T. Wilson Distinguished Service Professor in the Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics at the University of Chicago. He was born in P. R. China in 1972 and received his B.S. (1994) from the University of Science and Technology of China. He received his Ph.D. degree from Massachusetts Institute of Technology in chemistry in 2000 with Professor Stephen J. Lippard. After being trained as a Damon-Runyon postdoctoral fellow with Professor Gregory L. Verdine at Harvard Unive...
Source: Videocast - All Events - February 20, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Translating from Chemistry to Clinic with Deep Learning
NLM Informatics and Data Science Lecture Series
Many medicines become toxic only after bioactivation by metabolizing enzymes. Often, metabolic enzymes transformed them into chemically reactive species, which subsequently conjugate to proteins and cause adverse events. For example, carbamazepine is epoxidized by P450 enzymes in the liver, but then conjugates to proteins, causing Stevens Johnson Syndrome in some patients. The most difficult to predict drug reactions, idiosyncratic adverse drug reactions, often depend on bioactivation. Our group has been using deep learning to model the metabolism of diverse chemicals, and th...
Source: Videocast - All Events - February 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Application of MALDI-Ion Mobility Mass Spectrometry in Biological Analysis
Proteomics Interest Group
Ion mobility (IM) spectrometry is a robust method that allows for the rapid separation and detection of a wide range of compounds. In this technique, ions in the drift cell obtain an average drift velocity from an electric field based upon their collision cross section (W) or shape, which allows for the separation of molecules depending upon their three-dimensional structure. Combining matrix-assisted laser desorption/ionization (MALDI) mass spectrometry with IM results in the fast sorting of biomolecules in complex mixtures along trend lines. In this 2D analysis of biological families, lipids, pe...
Source: Videocast - All Events - January 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Preclinical cancer-target validation: How not to be wrong
Wednesday Afternoon Lecture Series
Published and unpublished studies by investigators in the pharmaceutical industry indicate that a disturbingly high number of academic laboratories' reports nominating potential new cancer-drug targets are either non-reproducible or, if reproducible, are not sufficiently robust to form the basis for drug-discovery efforts. The reasons are likely multifactorial, including the ubiquitous use of " down " assays in cancer biology (e.g. decreased cell proliferation, decreased tumor growth, etc.) that incorporate chemical and genetic perturbants that are prone to cause off-target effects, failu...
Source: Videocast - All Events - January 23, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Expedition on R/V Sikuliaq to study changing climate in arctic (Image 6)
Sediment cores collected from the sediment layers at the bottom of the ocean contain evidence of changing ocean biology and chemical processes. Miguel Goni (pictured), an oceanographer at Oregon State University, coordinated drilling activities onboard the R/V Sikuliaq during a Sept. 2016 ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - January 23, 2018 Category: Science Source Type: video
