Cardamom Extract Alleviates the Oxidative Stress, Inflammation and Apoptosis Induced during Acetaminophen-Induced Hepatic Toxicity via Modulating Nrf2/HO-1/NQO-1 Pathway
CONCLUSION: CARD extract mitigated the hepatic toxicity induced by APAP. The underlying mechanism of action of such hepato-protective action may be through upregulation of the Nrf2/HO-1/NQO-1 pathway with subsequent alleviation of the oxidative stress, inflammation and apoptosis induced by APAP. Many of the compounds identified in the CARD extract could be attributed to this pharmacological action of the extract.PMID:36354677 | DOI:10.3390/cimb44110365 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 10, 2022 Category: Molecular Biology Authors: Essraa A R Alkhalifah Amjad A Alobaid Marwah A Almajed Manar K Alomair Lama S Alabduladheem Sarah F Al-Subaie Abdullah Akbar Mahesh V Attimarad Nancy S Younis Maged E Mohamed Source Type: research
Cardamom Extract Alleviates the Oxidative Stress, Inflammation and Apoptosis Induced during Acetaminophen-Induced Hepatic Toxicity via Modulating Nrf2/HO-1/NQO-1 Pathway
CONCLUSION: CARD extract mitigated the hepatic toxicity induced by APAP. The underlying mechanism of action of such hepato-protective action may be through upregulation of the Nrf2/HO-1/NQO-1 pathway with subsequent alleviation of the oxidative stress, inflammation and apoptosis induced by APAP. Many of the compounds identified in the CARD extract could be attributed to this pharmacological action of the extract.PMID:36354677 | DOI:10.3390/cimb44110365 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 10, 2022 Category: Molecular Biology Authors: Essraa A R Alkhalifah Amjad A Alobaid Marwah A Almajed Manar K Alomair Lama S Alabduladheem Sarah F Al-Subaie Abdullah Akbar Mahesh V Attimarad Nancy S Younis Maged E Mohamed Source Type: research
From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders
Aging is described as an advanced time-related collection of changes that may negatively affect with the risk of several diseases or death. Aging is a main factor of several age-related neurological disorders, including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, and dementia), stroke, neuroinflammation, neurotoxicity, brain tumors, oxidative stress, and reactive oxygen species (ROS). Currently available medications for age-related neurological disorders may lead to several side effects, such as headache, diarrhea, nausea, gastrointestinal (GI) diseases, dyskinesia, and hallucinosis. These day...
Source: Frontiers in Pharmacology - November 10, 2022 Category: Drugs & Pharmacology Source Type: research
Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology
Appl Biochem Biotechnol. 2022 Oct 11:1-195. doi: 10.1007/s12010-022-04132-y. Online ahead of print.ABSTRACTMedicinal or herbal spices are grown in tropical moist evergreen forestland, surrounding most of the tropical and subtropical regions of Eastern Himalayas in India (Sikkim, Darjeeling regions), Bhutan, Nepal, Pakistan, Iran, Afghanistan, a few Central Asian countries, Middle East, USA, Europe, South East Asia, Japan, Malaysia, and Indonesia. According to the cultivation region surrounded, economic value, and vogue, these spices can be classified into major, minor, and colored tropical spices. In total, 24 tropical spi...
Source: Applied Biochemistry and Biotechnology - October 11, 2022 Category: Biochemistry Authors: Debopriya Mandal Tanmay Sarkar Runu Chakraborty Source Type: research
Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology
Appl Biochem Biotechnol. 2022 Oct 11. doi: 10.1007/s12010-022-04132-y. Online ahead of print.ABSTRACTMedicinal or herbal spices are grown in tropical moist evergreen forestland, surrounding most of the tropical and subtropical regions of Eastern Himalayas in India (Sikkim, Darjeeling regions), Bhutan, Nepal, Pakistan, Iran, Afghanistan, a few Central Asian countries, Middle East, USA, Europe, South East Asia, Japan, Malaysia, and Indonesia. According to the cultivation region surrounded, economic value, and vogue, these spices can be classified into major, minor, and colored tropical spices. In total, 24 tropical spices an...
Source: Applied Biochemistry and Biotechnology - October 11, 2022 Category: Biochemistry Authors: Debopriya Mandal Tanmay Sarkar Runu Chakraborty Source Type: research
On the Core Prescriptions and Their Mechanisms of Traditional Chinese Medicine in Hepatitis B, Liver Cirrhosis, and Liver Cancer Treatment
CONCLUSION: Three core prescriptions for hepatitis B, liver cirrhosis, and liver cancer treatment were identified, which acted mainly through signal transduction and immune system pathways to regulate immunity and cell growth and participate in inflammation inhibition, in which liver cancer prescription regulated more pathways, especially more nervous system-related pathways than the other two.PMID:36193202 | PMC:PMC9525786 | DOI:10.1155/2022/5300523 (Source: Journal of Oncology)
Source: Journal of Oncology - October 4, 2022 Category: Cancer & Oncology Authors: Zhendong Wang Yong Zhang Qiuyun Zhang Qiang Ao Changyong Luo Bochuan Wang Chen Bai Xueyi Ge Yuhan Wang Jing Wang Ying Qian He Yu Xiaohong Gu Source Type: research
In Silico Analysis of the Apoptotic and HPV Inhibitory Roles of Some Selected Phytochemicals Detected from the Rhizomes of Greater Cardamom
Appl Biochem Biotechnol. 2022 Jun 7. doi: 10.1007/s12010-022-04006-3. Online ahead of print.ABSTRACTOccurrence of cervical cancer, caused due to persistent human papilloma virus (HPV) infection, is common in women of developing countries. As the conventional treatments are expensive and associated with severe side effects, there is a need to find safer alternatives, which is affordable and less toxic to the healthy human cells. Present study aimed to evaluate the anti-HPV and apoptotic potential of four compounds from the greater cardamom (Amomum subulatum Roxb. var. Golsey), namely rhein, phytosphingosine, n-hexadecenoic ...
Source: Applied Biochemistry and Biotechnology - June 7, 2022 Category: Biochemistry Authors: Anish Nag Preeti Verma Subhabrata Paul Rita Kundu Source Type: research
In Silico Analysis of the Apoptotic and HPV Inhibitory Roles of Some Selected Phytochemicals Detected from the Rhizomes of Greater Cardamom
Appl Biochem Biotechnol. 2022 Jun 7. doi: 10.1007/s12010-022-04006-3. Online ahead of print.ABSTRACTOccurrence of cervical cancer, caused due to persistent human papilloma virus (HPV) infection, is common in women of developing countries. As the conventional treatments are expensive and associated with severe side effects, there is a need to find safer alternatives, which is affordable and less toxic to the healthy human cells. Present study aimed to evaluate the anti-HPV and apoptotic potential of four compounds from the greater cardamom (Amomum subulatum Roxb. var. Golsey), namely rhein, phytosphingosine, n-hexadecenoic ...
Source: Applied Biochemistry and Biotechnology - June 7, 2022 Category: Biochemistry Authors: Anish Nag Preeti Verma Subhabrata Paul Rita Kundu Source Type: research
Beneficial Effects of Black Cardamom ( < em > Amomum subulatum < /em > ) on Hemodynamic Parameters in Normotensive and Spontaneously Hypertensive Rats
Conclusion:</b> The obtained results suggest that AS has a hypotensive effect, with an impact on the HRV of NR and SHR. <i>Amomum subulatum</i> might cause an augmented effect on the cholinergic limb of the Autonomic Nervous System (ANS) and decrease the blood pressure and heart rate significantly.PMID:35638531 | DOI:10.3923/pjbs.2022.358.368 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - May 31, 2022 Category: Biomedical Science Authors: Abdul Halim Serafi Aisha Azmat Muhammad Ahmed Mohammed Bafail Zahir Hussain Source Type: research
Beneficial Effects of Black Cardamom ( < em > Amomum subulatum < /em > ) on Hemodynamic Parameters in Normotensive and Spontaneously Hypertensive Rats
Conclusion:</b> The obtained results suggest that AS has a hypotensive effect, with an impact on the HRV of NR and SHR. <i>Amomum subulatum</i> might cause an augmented effect on the cholinergic limb of the Autonomic Nervous System (ANS) and decrease the blood pressure and heart rate significantly.PMID:35638531 | DOI:10.3923/pjbs.2022.358.368 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - May 31, 2022 Category: Biomedical Science Authors: Abdul Halim Serafi Aisha Azmat Muhammad Ahmed Mohammed Bafail Zahir Hussain Source Type: research
Beneficial Effects of Black Cardamom ( < em > Amomum subulatum < /em > ) on Hemodynamic Parameters in Normotensive and Spontaneously Hypertensive Rats
Conclusion:</b> The obtained results suggest that AS has a hypotensive effect, with an impact on the HRV of NR and SHR. <i>Amomum subulatum</i> might cause an augmented effect on the cholinergic limb of the Autonomic Nervous System (ANS) and decrease the blood pressure and heart rate significantly.PMID:35638531 | DOI:10.3923/pjbs.2022.358.368 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - May 31, 2022 Category: Biomedical Science Authors: Abdul Halim Serafi Aisha Azmat Muhammad Ahmed Mohammed Bafail Zahir Hussain Source Type: research
Beneficial Effects of Black Cardamom ( < em > Amomum subulatum < /em > ) on Hemodynamic Parameters in Normotensive and Spontaneously Hypertensive Rats
Conclusion:</b> The obtained results suggest that AS has a hypotensive effect, with an impact on the HRV of NR and SHR. <i>Amomum subulatum</i> might cause an augmented effect on the cholinergic limb of the Autonomic Nervous System (ANS) and decrease the blood pressure and heart rate significantly.PMID:35638531 | DOI:10.3923/pjbs.2022.358.368 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - May 31, 2022 Category: Biomedical Science Authors: Abdul Halim Serafi Aisha Azmat Muhammad Ahmed Mohammed Bafail Zahir Hussain Source Type: research
Beneficial Effects of Black Cardamom ( < em > Amomum subulatum < /em > ) on Hemodynamic Parameters in Normotensive and Spontaneously Hypertensive Rats
Conclusion:</b> The obtained results suggest that AS has a hypotensive effect, with an impact on the HRV of NR and SHR. <i>Amomum subulatum</i> might cause an augmented effect on the cholinergic limb of the Autonomic Nervous System (ANS) and decrease the blood pressure and heart rate significantly.PMID:35638531 | DOI:10.3923/pjbs.2022.358.368 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - May 31, 2022 Category: Biomedical Science Authors: Abdul Halim Serafi Aisha Azmat Muhammad Ahmed Mohammed Bafail Zahir Hussain Source Type: research
Beneficial Effects of Black Cardamom ( < em > Amomum subulatum < /em > ) on Hemodynamic Parameters in Normotensive and Spontaneously Hypertensive Rats
Conclusion:</b> The obtained results suggest that AS has a hypotensive effect, with an impact on the HRV of NR and SHR. <i>Amomum subulatum</i> might cause an augmented effect on the cholinergic limb of the Autonomic Nervous System (ANS) and decrease the blood pressure and heart rate significantly.PMID:35638531 | DOI:10.3923/pjbs.2022.358.368 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - May 31, 2022 Category: Biomedical Science Authors: Abdul Halim Serafi Aisha Azmat Muhammad Ahmed Mohammed Bafail Zahir Hussain Source Type: research
