Cardamom Extract Alleviates the Oxidative Stress, Inflammation and Apoptosis Induced during Acetaminophen-Induced Hepatic Toxicity via Modulating Nrf2/HO-1/NQO-1 Pathway

CONCLUSION: CARD extract mitigated the hepatic toxicity induced by APAP. The underlying mechanism of action of such hepato-protective action may be through upregulation of the Nrf2/HO-1/NQO-1 pathway with subsequent alleviation of the oxidative stress, inflammation and apoptosis induced by APAP. Many of the compounds identified in the CARD extract could be attributed to this pharmacological action of the extract.PMID:36354677 | DOI:10.3390/cimb44110365

Source: Current Issues in Molecular Biology - November 10, 2022 Category: Molecular Biology Authors: Essraa A R Alkhalifah Amjad A Alobaid Marwah A Almajed Manar K Alomair Lama S Alabduladheem Sarah F Al-Subaie Abdullah Akbar Mahesh V Attimarad Nancy S Younis Maged E Mohamed Source Type: research