Role of orthopedia homebox protein in subclassification of pulmonary carcinoid tumors: Retrospective analysis of 110 cases
CONCLUSION: OTP does not provide significant results in the subclassification of typical and atypical carcinoid tumors and the evaluation of recurrence and survival of carcinoid tumor cases.PMID:38084533 | DOI:10.4103/ijpm.ijpm_210_22 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Mehmet Çetin G öktürk Fındık Funda Demira ğ İlteriş Türk Koray Aydo ğdu Source Type: research
Percutaneous computed tomography-guided core needle biopsy can be used to histologically confirm the clinical features and long-term prognosis of pulmonary neuroendocrine neoplasms
ConclusionPNENs may be pathologically diagnosed using PCT-CNB. While differential diagnoses between LCNEC and SCLC are problematic in some patients, a HGNEC-NOS diagnosis was ascribed and PCT-CNB samples were shown to predict NEN OS rates. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - December 1, 2023 Category: Radiology Source Type: research
Chemokine Receptor CXCR4 Radioligand Targeted Therapy Using 177Lutetium-pentixather for Pulmonary Neuroendocrine Cancers
Radiat Res. 2023 Nov 21. doi: 10.1667/RADE-23-00064.1. Online ahead of print.ABSTRACTIntermediate to high-grade lung neuroendocrine tumors (NETs; i.e., atypical carcinoid tumors) and neuroendocrine carcinomas (NECs) are currently difficult to cure. These tumors were found to express the CXCR4 G-protein coupled receptor that can be targeted with radioligands. PCR and flow cytometric analysis of lung NET and NEC cell lines using an anti-CXCR4 antibody demonstrated that all cell lines tested expressed CXCR4. PET/CT imaging with 68Galium-pentixafor in mouse xenografts of NETs and NECs verified tumor targeting that was blocked ...
Source: Radiation Research - November 21, 2023 Category: Physics Authors: Melissa A Fath Dijie Liu Jordan T Ewald Claudia Robles-Planells Ann M Tomanek-Chalkley Stephen A Graves James R Howe Thomas M O'Dorisio Prerna Rastogi Andrew M Bellizzi M Sue O'Dorisio Yusuf Menda Douglas R Spitz Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Braz J Med Biol Res - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Brazilian Journal of Medical and Biological Research - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Braz J Med Biol Res - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Brazilian Journal of Medical and Biological Research - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Braz J Med Biol Res - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Brazilian Journal of Medical and Biological Research - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Braz J Med Biol Res - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Brazilian Journal of Medical and Biological Research - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Braz J Med Biol Res - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Braz J Med Biol Res - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Brazilian Journal of Medical and Biological Research - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining
This study examined the potential association between Ki-67 NG and cell cycle phases and its effect on the prognosis of pulmonary typical carcinoid (PTC) tumors. We propose a method for classifying the NG of Ki-67 during the cell cycle and compare the results between PTC, pulmonary adenocarcinoma (PAD), and breast ductal carcinoma (BDC). A literature review and objective analysis of IHC-stained paraffin sections were used to determine the Ki-67 labeling index and composed a stratification of the NG into NG1, NG2, and NG3/4 categories. A semi-automated image analysis protocol was established to determine the Ki-67 NG in PTC...
Source: Braz J Med Biol Res - November 16, 2023 Category: Research Authors: S M Fernezlian C M Baldavira M L F de Souza C Farhat A F de Vilhena J C N Pereira J R M de Campos T Takagaki M L Balancin A M Ab'Saber V L Capelozzi Source Type: research
