Bronchial Carcinoid : CT Findings
History: A 31 years male presented with 6 weeks history of breathlessness and intermittent hemoptysis. CT scan was performed and show belowFindings:An intrabrocnchial soft tissue lesion is seen obstructing the left lower lobe bronchus with distal atelectasis. The soft tissue shows eccentric foci of calcification. The lesion shows significant post contrast enhancement in arterial phaseDiagnosis:These imaging findings are typical of a Carcinoid tumorFamous Radiology Blog by Dr Sumer Sethi www.sumersethi.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 3, 2022 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Neuroendocrine tumors of GI Tract.
The World Health Organization (WHO) classifies neuroendocrine neoplasms as well-differentiated neuroendocrine tumors (either the primary tumor or metastasis) and poorly differentiated neuroendocrine carcinomas.Historically, well-differentiated neuroendocrine tumors have been referred to as “carcinoid tumors,” a term which may cause confusion because clinically a carcinoid tumor is a serotonin-producing tumor associated with functional manifestations of carcinoid syndrome.The use of the term “carcinoid” for neuroendocrine tumor reporting is therefore discouraged for these reasons.Immunohistochemistry and other ancil...
Source: Oncopathology - January 22, 2020 Category: Cancer & Oncology Source Type: blogs
DM / DNB Cardiology Entrance Mock Test 13
In this study, cangrelor was discontinued 1-6 hours prior to surgery, while aspirin was continued throughout the perioperative period. Bridging with cangrelor did not increase major bleeds prior to surgery, though minor bleeds, mostly ecchymosis at venipuncture site, was higher. P2Y12 assay documented sufficient platelet inhibition corresponding to levels required for anti thrombotic effect [1]. Cangrelor is awaiting approval and more large scale trials regarding the use of bridging are needed.
Reference
1. Angiolillo DJ et al; BRIDGE Investigators. Bridging antiplatelet therapy with cangrelor in patients undergoing ...
Source: Cardiophile MD - February 7, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
DM / DNB Cardiology Entrance Mock Test 12
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Source: Cardiophile MD - February 4, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
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Pathology, classification, and grading of neuroendocrine tumors arising in the digestive systemThe terminology of gastroenteropancreatic (GEP) neuroendocrine neoplasms has evolved over the past two decades to reflect a separation into two major categories:●Well-differentiated neuroendocrine tumors (NETs) show a solid, trabecular, gyriform, or glandular pattern, with fairly uniform nuclei, salt-and-pepper chromatin, and finely granular cytoplasm. These tumors were traditionally referred to as carcinoid and pancreatic neuroendocrine (islet cell) tumors. Although carcinoid tumors and pancreatic NETs may have simi...
Source: Oncopathology - January 27, 2016 Category: Cancer & Oncology Source Type: blogs
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Pathology, classification, and grading of neuroendocrine tumors arising in the digestive systemThe terminology of gastroenteropancreatic (GEP) neuroendocrine neoplasms has evolved over the past two decades to reflect a separation into two major categories:●Well-differentiated neuroendocrine tumors (NETs) show a solid, trabecular, gyriform, or glandular pattern, with fairly uniform nuclei, salt-and-pepper chromatin, and finely granular cytoplasm. These tumors were traditionally referred to as carcinoid and pancreatic neuroendocrine (islet cell) tumors. Although carcinoid tumors and pancreatic NETs may have simil...
Source: Oncopathology - January 27, 2016 Category: Cancer & Oncology Source Type: blogs
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Pathology, classification, and grading of neuroendocrine tumors arising in the digestive systemThe terminology of gastroenteropancreatic (GEP) neuroendocrine neoplasms has evolved over the past two decades to reflect a separation into two major categories:●Well-differentiated neuroendocrine tumors (NETs) show a solid, trabecular, gyriform, or glandular pattern, with fairly uniform nuclei, salt-and-pepper chromatin, and finely granular cytoplasm. These tumors were traditionally referred to as carcinoid and pancreatic neuroendocrine (islet cell) tumors. Although carcinoid tumors and pancreatic NETs may have simil...
Source: Oncopathology - January 27, 2016 Category: Cancer & Oncology Source Type: blogs
The Three Types of Lung Cancer
Researchers have identified three types of lung cancer. The most prevalent is non-small cell lung cancer, followed by small cell cancer. Both types of cancers have similar risk factors that include smoking and inhalation of secondhand smoke. Interestingly, the third type – lung carcinoid tumor – is not tied to the use of tobacco products.
Non-Small Cell Lung Cancer
This type of lung cancer, which currently does not have a... (Source: Dorian Martin's SharePosts)
Source: Dorian Martin's SharePosts - December 9, 2015 Category: Consumer Health News Authors: Dorian Martin Source Type: blogs
Cardiology MCQ 273: Diagnostic tests for carcinoid
Which of the following is not a diagnostic test for carcinoid syndrome?
a. 24 hour urine 5-HIAA
b. 24 hour urine VMA
c. Chromogranin A
d. 111In-pentetreotide scanning
["Click here for the answer with explanation", "Correct Answer:"]
b. 24 hour urine VMA
Urine VMA (Vanillylmandelic acid) estimation is done for the diagnosis of pheochromocytomas. 5-H1AA (5-Hydroxy indole acetic acid) and chromogranin A are used for diagnosis of carcinoid syndrome, while 111In-pentetreotide scanning is useful in locating the tumour as well. Read more… (Source: Cardiophile MD)
Source: Cardiophile MD - July 27, 2014 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Diagnostic tests for carcinoid syndrome
Carcinoid syndrome is usually a manifestation of metastatic carcinoid tumor. This is because the liver acts as a first filter metabolizing hormones secreted by the carcinoid tumor draining into the portal circulation. An exception would be ovarian carcinoid which can drain into the systemic circulation.
Biochemical markers of carcinoid syndrome
5-HIAA (5-Hydroxy indole acetic acid)
5-HIAA is the metabolite of serotonin released from the carcinoid tumor. 24 hour urinary 5-HIAA estimation has about 73% sensitivity and nearly 100% specificity for diagnosis of carcinoid syndrome.
CgA (Chromogranin A)
Chromogranin A (CgA) is s...
Source: Cardiophile MD - July 26, 2014 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology 111In-pentetreotide scanning 123I-MIBG scan 24 hour urinary 5-HIAA estimation 5-Hydroxy indole acetic acid Biochemical markers of carcinoid syndrome CgA Chromogranin A computerized tomography CT diagnosis of carcinoi Source Type: blogs
Carcinoid syndrome
is characterized by episodic flushes, abdominal pain, diarrhea etc due to a serotonin secreting carcinoid tumour.
Wrong statement about carcinoid syndrome
1. 5-HIAA (5-Hydroxyindoleacetic acid) level in urine is elevated
2. Left sided heart valves are commonly involved
3. Octreotide radiolabelled scan is useful in diagnosis
4. Indicates hepatic metastasis
Correct answer: 2. Left sided heart valves are commonly involved
5-HIAA is a metabolite of serotonin and is detected in increased quantity in urine in those with carcinoid syndrome and hence can be used as a diagnostic lab test.
Intestinal carcinoid tumor without meta...
Source: Cardiophile MD - April 19, 2014 Category: Cardiology Authors: Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Blaming Obamacare is the wrong diagnosis
The Wall Street Journal began the week by publishing a provocative essay in which a young man suggested Obamacare kept his mother from getting appropriate medicine for her cancer. The writer crafted a poignant story about his mother, who sounds like a good person with a bad disease.
Mainstream media buzzes with these types of stories. The Obamacare-is-the-problem narrative fits quite well on conservative news outlets.
The problem, as it so often is, is in the details.
The story here begins with a familiar first chapter: the writer’s mother had good insurance coverage but then it was cancelled. Next came her struggle...
Source: Dr John M - February 25, 2014 Category: Cardiology Authors: Dr John Source Type: blogs
Carcinoid Tumor
Carcinoid tumor is a type of neuroendocrine tumor
Pathophysiology
1) contains and may secrete physiologically active substances
2) occurs in GI tract (appendix, rectum, small bowel, stomach), thymus, lung, ovary, and testes
3) produces “local” symptoms, systemic but non-carcinoid syndrome symptoms, and systemic carcinoid syndrome symptoms
Signs and Symptoms of Carcinoid Tumor
Local Symptoms
1) appendix – usually asymptomatic and found incidentally on appendectomy
2) small intestine – obstruction, episodic abdominal pain, bleeding
3) rectum – bleeding, constipation, and diarrhea
4) stomach/thym...
Source: Inside Surgery - November 18, 2013 Category: Surgeons Authors: Editor Tags: Oncology 5-HIAA appendix flushing GI metastases motilin serotonin Source Type: blogs
See them for who they are and not for the illnesses they have
Jane Carmody is Chief Nursing Officer at Alegent Creighton Health in Omaha, Nebraska. She publishes a regular note from the CNO for the hospital staff. This personal account moved me, and I reprint it with her permission. Courage. My sister is about nine years older than me. For about ten years she has battled carcinoid tumors, and it is starting to take its toll. I visit her about every weekend I can; she lives in Des Moines. I have to say how I admire her courage. She is a nurse and worked for years at her small town clinic with the physician and the nurse practitioner. They “huddled” every da...
Source: Running a hospital - August 22, 2013 Category: Health Managers Source Type: blogs
