Clinical Benefits of Therapeutic Interventions Targeting Mitochondria in Parkinson's Disease Patients
In conclusion, targeting mitochondrial dysfunction in Parkinson's disease is a promising therapeutic approach, although only one compound has shown a positive effect on Parkinson's disease progression and symptoms. New compounds have been investigated in animal models, and their efficacy needs to be confirmed in humans through robust, randomised, double-blind clinical trials.PMID:37005519 | DOI:10.2174/1871527322666230330122444 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - April 3, 2023 Category: Drugs & Pharmacology Authors: Matteo Ciocca Chiara Pizzamiglio Source Type: research
Glucagon-like peptide 1 receptor agonists and the potential risk of pancreatic carcinoma: a pharmacovigilance study using the FDA Adverse Event Reporting System and literature visualization analysis
ConclusionBased on this pharmacovigilance study, GLP-1RAs, except albiglutide, are associated with pancreatic carcinoma. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 28, 2023 Category: Drugs & Pharmacology Source Type: research
Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration
ConclusionsExenatide increased hepatic mitochondrial respiration in high-fat fed mice, but no clear beneficial effect was observed in skeletal muscle or fat tissue. Calanus oil did not negatively affect respiratory activity in these tissues, which maintains its potential as a dietary supplement, due to its previously reported benefits on cardiac function (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 23, 2023 Category: Endocrinology Source Type: research
Glucagon and exenatide improve contractile recovery following ischaemia/reperfusion in the isolated perfused rat heart
Glucagon and exenatide, a glucagon-like peptide 1 (GLP-1) receptor agonist, combine to stimulate greater recovery of post-ischaemic contractile function in the Langendorff heart. Glucagon was inotropic and chronotropic, yet this initial effect decreased over time and did not account for the increased contractility observed post ischaemia/reperfusion. AbstractThe inotropic effects of glucagon have been recognized for many years, but it has remained unclear whether glucagon signaling is beneficial to cardiac function. We evaluated the effects of glucagon alone and in combination with the glucagon-like peptide 1 (GLP-1) recep...
Source: Physiological Reports - March 22, 2023 Category: Physiology Authors: Ross T. Lindsay,
Philip Ambery,
Lutz Jermutus,
Andrew J. Murray Tags: ORIGINAL ARTICLE Source Type: research
Effect of Exenatide on Nonalcoholic Steatohepatitis and Inflammation-Related Indices in Diabetic Patients with Non-Alcoholic Fatty Liver Disease
Metabolic Syndrome and Related Disorders, Ahead of Print. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - March 21, 2023 Category: Endocrinology Authors: Burak Menek şe Adnan Batman Source Type: research
Corrigendum to "Exenatide ameliorates hydrogen peroxide-induced pancreatic β-cell apoptosis through regulation of METTL3-mediated m < sup > 6 < /sup > A methylation" [Eur. J. Pharmacol. 924 (2022) 174960]
Eur J Pharmacol. 2023 Mar 14;946:175652. doi: 10.1016/j.ejphar.2023.175652. Online ahead of print.NO ABSTRACTPMID:36924576 | DOI:10.1016/j.ejphar.2023.175652 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Authors: Simin Zhou Yue Sun Yujie Xing Zhi Wang Shujun Wan Xinming Yao Qiang Hua Xiangjian Meng Jinhan Cheng Min Zhong Kun Lv Xiang Kong Source Type: research
Corrigendum to "Exenatide ameliorates hydrogen peroxide-induced pancreatic β-cell apoptosis through regulation of METTL3-mediated m < sup > 6 < /sup > A methylation" [Eur. J. Pharmacol. 924 (2022) 174960]
Eur J Pharmacol. 2023 Mar 14;946:175652. doi: 10.1016/j.ejphar.2023.175652. Online ahead of print.NO ABSTRACTPMID:36924576 | DOI:10.1016/j.ejphar.2023.175652 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Authors: Simin Zhou Yue Sun Yujie Xing Zhi Wang Shujun Wan Xinming Yao Qiang Hua Xiangjian Meng Jinhan Cheng Min Zhong Kun Lv Xiang Kong Source Type: research
Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy
This study aimed to explore the possible cytoprotective effects of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the testicles of diabetic rats. Exenatide has numerous advantageous properties in addition to its hypoglycemic effect. However, its impact on testicular tissue in diabetes needs more clarification. Therefore, rats were divided into control, exenatide-treated, diabetic and exenatide-treated diabetic groups. Blood glucose and serum levels of insulin, testosterone, pituitary gonadotropins and kisspeptin-1 were measured. Real-time PCR for beclin-1, p62, mammalian target of rapamycin (mTOR), and A...
Source: General Physiology and Biophysics - March 10, 2023 Category: Physiology Authors: Elshymaa A Abdel-Hakeem Nagwa M Zenhom Sahar A Mokhemer Source Type: research
Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy
This study aimed to explore the possible cytoprotective effects of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the testicles of diabetic rats. Exenatide has numerous advantageous properties in addition to its hypoglycemic effect. However, its impact on testicular tissue in diabetes needs more clarification. Therefore, rats were divided into control, exenatide-treated, diabetic and exenatide-treated diabetic groups. Blood glucose and serum levels of insulin, testosterone, pituitary gonadotropins and kisspeptin-1 were measured. Real-time PCR for beclin-1, p62, mammalian target of rapamycin (mTOR), and A...
Source: General Physiology and Biophysics - March 10, 2023 Category: Physiology Authors: Elshymaa A Abdel-Hakeem Nagwa M Zenhom Sahar A Mokhemer Source Type: research
Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy
This study aimed to explore the possible cytoprotective effects of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the testicles of diabetic rats. Exenatide has numerous advantageous properties in addition to its hypoglycemic effect. However, its impact on testicular tissue in diabetes needs more clarification. Therefore, rats were divided into control, exenatide-treated, diabetic and exenatide-treated diabetic groups. Blood glucose and serum levels of insulin, testosterone, pituitary gonadotropins and kisspeptin-1 were measured. Real-time PCR for beclin-1, p62, mammalian target of rapamycin (mTOR), and A...
Source: General Physiology and Biophysics - March 10, 2023 Category: Physiology Authors: Elshymaa A Abdel-Hakeem Nagwa M Zenhom Sahar A Mokhemer Source Type: research
Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy
This study aimed to explore the possible cytoprotective effects of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the testicles of diabetic rats. Exenatide has numerous advantageous properties in addition to its hypoglycemic effect. However, its impact on testicular tissue in diabetes needs more clarification. Therefore, rats were divided into control, exenatide-treated, diabetic and exenatide-treated diabetic groups. Blood glucose and serum levels of insulin, testosterone, pituitary gonadotropins and kisspeptin-1 were measured. Real-time PCR for beclin-1, p62, mammalian target of rapamycin (mTOR), and A...
Source: General Physiology and Biophysics - March 10, 2023 Category: Physiology Authors: Elshymaa A Abdel-Hakeem Nagwa M Zenhom Sahar A Mokhemer Source Type: research
Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy
This study aimed to explore the possible cytoprotective effects of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the testicles of diabetic rats. Exenatide has numerous advantageous properties in addition to its hypoglycemic effect. However, its impact on testicular tissue in diabetes needs more clarification. Therefore, rats were divided into control, exenatide-treated, diabetic and exenatide-treated diabetic groups. Blood glucose and serum levels of insulin, testosterone, pituitary gonadotropins and kisspeptin-1 were measured. Real-time PCR for beclin-1, p62, mammalian target of rapamycin (mTOR), and A...
Source: General Physiology and Biophysics - March 10, 2023 Category: Physiology Authors: Elshymaa A Abdel-Hakeem Nagwa M Zenhom Sahar A Mokhemer Source Type: research
Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy
This study aimed to explore the possible cytoprotective effects of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the testicles of diabetic rats. Exenatide has numerous advantageous properties in addition to its hypoglycemic effect. However, its impact on testicular tissue in diabetes needs more clarification. Therefore, rats were divided into control, exenatide-treated, diabetic and exenatide-treated diabetic groups. Blood glucose and serum levels of insulin, testosterone, pituitary gonadotropins and kisspeptin-1 were measured. Real-time PCR for beclin-1, p62, mammalian target of rapamycin (mTOR), and A...
Source: General Physiology and Biophysics - March 10, 2023 Category: Physiology Authors: Elshymaa A Abdel-Hakeem Nagwa M Zenhom Sahar A Mokhemer Source Type: research
Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy
This study aimed to explore the possible cytoprotective effects of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the testicles of diabetic rats. Exenatide has numerous advantageous properties in addition to its hypoglycemic effect. However, its impact on testicular tissue in diabetes needs more clarification. Therefore, rats were divided into control, exenatide-treated, diabetic and exenatide-treated diabetic groups. Blood glucose and serum levels of insulin, testosterone, pituitary gonadotropins and kisspeptin-1 were measured. Real-time PCR for beclin-1, p62, mammalian target of rapamycin (mTOR), and A...
Source: General Physiology and Biophysics - March 10, 2023 Category: Physiology Authors: Elshymaa A Abdel-Hakeem Nagwa M Zenhom Sahar A Mokhemer Source Type: research
