Comparison of exenatide alone or combined with metformin versus metformin in the treatment of polycystic ovaries: a systematic review and meta-analysis
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of childbearing age. Randomized controlled trials (RCTs) have reported that exenatide and metformin are effective i... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - November 16, 2023 Category: Endocrinology Authors: Yan Hu, Xiangxin Song, Shaila Hamiti, Yanyong Ma, Mainu Yusufu, Xing Wang, Kaidi Zhang and Yanying Guo Tags: Research Source Type: research
Case Series: Exposure to Glucagon-like Peptide-1 Receptor Agonist in the First Trimester of Pregnancy in Two Siblings
CONCLUSION: This report contributes to our knowledge of fetal exposure to exenatide. Large-scale randomized studies are needed for its safe use in pregnancy.PMID:37937565 | DOI:10.2174/0118715303252109231023115112 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 8, 2023 Category: Endocrinology Authors: Şerife Ezgi Doğan Şerife Mehlika Kuşkonmaz Gonul Koc Ebru Aypar Cavit Çulha Source Type: research
Case Series: Exposure to Glucagon-like Peptide-1 Receptor Agonist in the First Trimester of Pregnancy in Two Siblings
CONCLUSION: This report contributes to our knowledge of fetal exposure to exenatide. Large-scale randomized studies are needed for its safe use in pregnancy.PMID:37937565 | DOI:10.2174/0118715303252109231023115112 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 8, 2023 Category: Drugs & Pharmacology Authors: Şerife Ezgi Doğan Şerife Mehlika Kuşkonmaz Gonul Koc Ebru Aypar Cavit Çulha Source Type: research
Case Series: Exposure to Glucagon-like Peptide-1 Receptor Agonist in the First Trimester of Pregnancy in Two Siblings
CONCLUSION: This report contributes to our knowledge of fetal exposure to exenatide. Large-scale randomized studies are needed for its safe use in pregnancy.PMID:37937565 | DOI:10.2174/0118715303252109231023115112 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 8, 2023 Category: Endocrinology Authors: Şerife Ezgi Doğan Şerife Mehlika Kuşkonmaz Gonul Koc Ebru Aypar Cavit Çulha Source Type: research
Case Series: Exposure to Glucagon-like Peptide-1 Receptor Agonist in the First Trimester of Pregnancy in Two Siblings
CONCLUSION: This report contributes to our knowledge of fetal exposure to exenatide. Large-scale randomized studies are needed for its safe use in pregnancy.PMID:37937565 | DOI:10.2174/0118715303252109231023115112 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 8, 2023 Category: Drugs & Pharmacology Authors: Şerife Ezgi Doğan Şerife Mehlika Kuşkonmaz Gonul Koc Ebru Aypar Cavit Çulha Source Type: research
Adolescents with obesity treated with exenatide maintain endogenous GLP-1, reduce DPP-4, and improve glycemic control
ConclusionWeekly s.c. injections with 2 mg of exenatide maintains endogenous total GLP-1 levels and lowers circulating DPP-4 levels. This adds an argument in favor of using exenatide in the treatment of pediatric obesity.Clinical trial registrationclinicaltrials.gov, identifier NCT02794402 (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 1, 2023 Category: Endocrinology Source Type: research
Effects of GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation on offspring outcomes: a systematic review of the evidence
Conclusion/interpretationWe found evidence for adverse offspring effects of GLP-1 agonists and SGLT2 inhibitors also in human studies. Our findings broadly support the advice to discontinue GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation, and also support the ongoing registration of pregnancy outcomes in pharmacological databases since the amount of available data is scarce and mostly limited to animal studies.Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=219877 (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - October 10, 2023 Category: Endocrinology Source Type: research
Predictors of glycemic and weight responses to exenatide in patients with type 2 diabetes mellitus
ConclusionBaseline HbA1c, baseline weight, and duration of diabetes may serve as predictors for glycemic and weight responses to exenatide. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - October 4, 2023 Category: Endocrinology Source Type: research
Insulin Glargine is More Suitable Than Exenatide in Preventing Muscle
Loss in Non-Obese Type 2 Diabetic Patients with NAFLD
Conclusion Compared to exenatide, insulin glargine can relativity increase
PMA in patients with T2DM having BMI<28 kg/m2
and NAFLD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - October 4, 2023 Category: Endocrinology Authors: Liu, Lin Wang, Ruwen Gao, Jian Yan, Jianhua Zhang, Jingtian Zhang, Zhitian Liu, Jiaojiao Lin, Huandong Rao, Shengxiang Yao, Xiuzhong Wu, Weiyun Bian, Hua Wang, Xiangyu Guo, Shanshan Gao, Xin Yan, Hongmei Tags: Article Source Type: research
Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres
Eur J Pharm Biopharm. 2023 Sep 30:S0939-6411(23)00259-X. doi: 10.1016/j.ejpb.2023.09.016. Online ahead of print.ABSTRACTDue to the lack of pharmacopeia guidelines for injectable microspheres based on poly (D, L-lactide-co-glycolide) (PLGA), an internal method validation is a critical prerequisite for quality assurance. One of the essential issues of developing peptide-based drugs loaded PLGA microspheres is the precise determination of the amount of peptide drug entrapped in the microspheres. The aim of this study is the development and optimization of a method for measuring the drug content loading of PLGA microspheres us...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 2, 2023 Category: Drugs & Pharmacology Authors: Mojgan Sheikhi Mohammad Sharifzadeh Wim E Hennink Loghman Firoozpour Mannan Hajimahmoudi Mohammad Reza Khoshayand Mehrnoosh Shirangi Source Type: research
Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres
Eur J Pharm Biopharm. 2023 Sep 30:S0939-6411(23)00259-X. doi: 10.1016/j.ejpb.2023.09.016. Online ahead of print.ABSTRACTDue to the lack of pharmacopeia guidelines for injectable microspheres based on poly (D, L-lactide-co-glycolide) (PLGA), an internal method validation is a critical prerequisite for quality assurance. One of the essential issues of developing peptide-based drugs loaded PLGA microspheres is the precise determination of the amount of peptide drug entrapped in the microspheres. The aim of this study is the development and optimization of a method for measuring the drug content loading of PLGA microspheres us...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 2, 2023 Category: Drugs & Pharmacology Authors: Mojgan Sheikhi Mohammad Sharifzadeh Wim E Hennink Loghman Firoozpour Mannan Hajimahmoudi Mohammad Reza Khoshayand Mehrnoosh Shirangi Source Type: research
Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres
Eur J Pharm Biopharm. 2023 Sep 30:S0939-6411(23)00259-X. doi: 10.1016/j.ejpb.2023.09.016. Online ahead of print.ABSTRACTDue to the lack of pharmacopeia guidelines for injectable microspheres based on poly (D, L-lactide-co-glycolide) (PLGA), an internal method validation is a critical prerequisite for quality assurance. One of the essential issues of developing peptide-based drugs loaded PLGA microspheres is the precise determination of the amount of peptide drug entrapped in the microspheres. The aim of this study is the development and optimization of a method for measuring the drug content loading of PLGA microspheres us...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 2, 2023 Category: Drugs & Pharmacology Authors: Mojgan Sheikhi Mohammad Sharifzadeh Wim E Hennink Loghman Firoozpour Mannan Hajimahmoudi Mohammad Reza Khoshayand Mehrnoosh Shirangi Source Type: research
Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres
Eur J Pharm Biopharm. 2023 Sep 30:S0939-6411(23)00259-X. doi: 10.1016/j.ejpb.2023.09.016. Online ahead of print.ABSTRACTDue to the lack of pharmacopeia guidelines for injectable microspheres based on poly (D, L-lactide-co-glycolide) (PLGA), an internal method validation is a critical prerequisite for quality assurance. One of the essential issues of developing peptide-based drugs loaded PLGA microspheres is the precise determination of the amount of peptide drug entrapped in the microspheres. The aim of this study is the development and optimization of a method for measuring the drug content loading of PLGA microspheres us...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 2, 2023 Category: Drugs & Pharmacology Authors: Mojgan Sheikhi Mohammad Sharifzadeh Wim E Hennink Loghman Firoozpour Mannan Hajimahmoudi Mohammad Reza Khoshayand Mehrnoosh Shirangi Source Type: research
