[ASAP] Glycosylation Improves the Proteolytic Stability of Exenatide
Bioconjugate ChemistryDOI: 10.1021/acs.bioconjchem.3c00120 (Source: Bioconjugate Chemistry)
Source: Bioconjugate Chemistry - May 16, 2023 Category: Biochemistry Authors: Chaitra Chandrashekar, Yuji Nishiuchi, Barbara Fam White, Yanni Arsenakis, Feng Lin, Samantha M. McNeill, Peishen Zhao, Sam van Dun, Anna Koijen, Yasuhiro Kajihara, Denise Wootten, Leendert J. van den Bos, John D. Wade, and Mohammed Akhter Hossain & Source Type: research
Free T4 is associated with exenatide-related weight loss in patients with type 2 diabetes mellitus and obesity
ConclusionExenatide provides more weight loss in the patients with higher baseline BMI or fT4. Thyroid function remains unchanged during treatment. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 14, 2023 Category: Endocrinology Source Type: research
A novel peptide isolated from Aphonopelma chalcodes tarantula venom with benefits on pancreatic islet function and appetite control
Biochem Pharmacol. 2023 Apr 10:115544. doi: 10.1016/j.bcp.2023.115544. Online ahead of print.ABSTRACTProof-of-concept for therapeutic application of venom-derived compounds in diabetes is exemplified by the incretin mimetic, exenatide, originally extracted from the saliva of the venomous Heloderma suspectum lizard. In this regard, we have isolated and sequenced a novel 28 amino acid peptide named Δ-theraphotoxin-Ac1 (Δ-TRTX-AC1) from venom of the Mexican Blond tarantula spider Aphonopelma chalcodes, with potential therapeutic benefits for diabetes. Following confirmation of the structure and safety profile of the synthet...
Source: Biochemical Pharmacology - April 12, 2023 Category: Drugs & Pharmacology Authors: A Coulter-Parkhill Swm Dobbin N Tanday V A Gault S McClean N Irwin Source Type: research
A novel peptide isolated from Aphonopelma chalcodes tarantula venom with benefits on pancreatic islet function and appetite control
Biochem Pharmacol. 2023 Apr 10:115544. doi: 10.1016/j.bcp.2023.115544. Online ahead of print.ABSTRACTProof-of-concept for therapeutic application of venom-derived compounds in diabetes is exemplified by the incretin mimetic, exenatide, originally extracted from the saliva of the venomous Heloderma suspectum lizard. In this regard, we have isolated and sequenced a novel 28 amino acid peptide named Δ-theraphotoxin-Ac1 (Δ-TRTX-AC1) from venom of the Mexican Blond tarantula spider Aphonopelma chalcodes, with potential therapeutic benefits for diabetes. Following confirmation of the structure and safety profile of the synthet...
Source: Biochemical Pharmacology - April 12, 2023 Category: Drugs & Pharmacology Authors: A Coulter-Parkhill Swm Dobbin N Tanday V A Gault S McClean N Irwin Source Type: research
Clinical Benefits of Therapeutic Interventions Targeting Mitochondria in Parkinson's Disease Patients
In conclusion, targeting mitochondrial dysfunction in Parkinson's disease is a promising therapeutic approach, although only one compound has shown a positive effect on Parkinson's disease progression and symptoms. New compounds have been investigated in animal models, and their efficacy needs to be confirmed in humans through robust, randomised, double-blind clinical trials.PMID:37005519 | DOI:10.2174/1871527322666230330122444 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - April 3, 2023 Category: Drugs & Pharmacology Authors: Matteo Ciocca Chiara Pizzamiglio Source Type: research
