PEGylated exenatide injection (PB-119) improves beta-cell function and insulin resistance in treatment-na ïve type 2 diabetes mellitus patients
Conclusion: After 12 weeks of treatment, PB-119 decreased glycemic levels by improving beta-cell function and insulin resistance. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 14, 2023 Category: Drugs & Pharmacology Source Type: research
Double layer spherical Nanoparticles with Hyaluronic Acid Coating to Enhance Oral Delivery of Exenatide in T2DM rats
Eur J Pharm Biopharm. 2023 Sep 6:S0939-6411(23)00236-9. doi: 10.1016/j.ejpb.2023.09.003. Online ahead of print.ABSTRACTSoybean phospholipid was used as an amphiphilic material to form reverse micelles (RMs) in medium glycerol monolinoleate (Maisine) with Exenatide (EXT.) encapsulated in the polar core formed by the hydrophilic part of phospholipid. Cremopher RH40 and caprylocaproyl macrogol-8 glycerides EP/caprylocaproyl polyoxyl-8 glycerides NF (Labrasol) were added as surfactants to prepare reverse micelle-self emulsifying drug delivery system (RMs-SEDDS). On this basis, oil in water (O/W) emulsion was further prepared. ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 8, 2023 Category: Drugs & Pharmacology Authors: Yiying Lu Linjie Wu Mengting Lin Xiaoyan Bao Haiqing Zhong Peng Ke Qi Dai Qiyao Yang Xinjiang Tang WenHong Xu DongHang Xu Min Han Source Type: research
Early effect of exenatide treatment on atherogenicity in patients with type 2 diabetes mellitus
ConclusionIn addition to its commonly known effects such as lowering FPG levels and weight loss, exenatide has been observed to have a positive effect on traditional lipid profiles and atherogenicity-related indices. In addition to its antidiabetic effect, it should be considered in diabetic patients in treatment options for atherosclerotic cardiovascular prevention. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - August 31, 2023 Category: Endocrinology Source Type: research
Comparison of the efficacy and safety of 10 glucagon-like peptide-1 receptor agonists as add-on to metformin in patients with type 2 diabetes: a systematic review
ConclusionThis study’s results showed that GLP-1RAs were effective in lowering HbA1c and reducing body weight without increased incidence of hypoglycemic reactions. In addition, this study may provide reference and evidence-based medical evidence for clinicians to select GLP-1RAs in patients with T2D and high body mass index (BMI). Based on the NMA results, tirzepatide 15mg and semaglutide 1.0mg may be preferred. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - August 28, 2023 Category: Endocrinology Source Type: research
Treatment for Type 2 Diabetes May Reduce Depressive Symptoms in Some Adults
Glucagon-like peptide-1 (GLP-1) receptor agonists —a common treatment for type 2 diabetes—may also help to reduce depressive symptoms in adults, suggests ameta-analysis published inThe American Journal of Geriatric Psychiatry.People with diabetes are known to be at greater risk of depression than those without the disease, wrote co-author Lixin Guo, M.D., of the Chinese Academy of Medical Sciences and colleagues. Though GLP-1 is a hormone produced in the gut that is released in response to food, GLP receptors are also present in the brain. Animal studies have suggested that activation of these receptors may produce ant...
Source: Psychiatr News - August 22, 2023 Category: Psychiatry Tags: antidepressant effects depression diabetes GLP-1 GLP-1 receptor agonist Parkinson ' s disease The American Journal of Geriatric Psychiatry Source Type: research
Correction to "Exenatide for weight-loss maintenance in adolescents with severe obesity: A randomized, placebo-controlled trial"
Obesity (Silver Spring). 2023 Aug 10. doi: 10.1002/oby.23843. Online ahead of print.NO ABSTRACTPMID:37559487 | DOI:10.1002/oby.23843 (Source: Obesity)
Source: Obesity - August 10, 2023 Category: Eating Disorders & Weight Management Source Type: research
Glucagon-like peptide 1 Analogues as Adjunctive Therapy for Patients with Type 1 Diabetes: an Updated Systematic Review and Meta-analysis
CONCLUSION: Our meta-analysis supports the therapeutic benefits of liraglutide for patients with T1DM mainly for weight loss and insulin dose reduction. Newly diagnosed or C-pos patients do not appear to experience greater weight loss benefits.PMID:37561012 | DOI:10.1210/clinem/dgad471 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 10, 2023 Category: Endocrinology Authors: Jeayoung Park Spyridon Ntelis Elvina Yunasan Katherine D Downton Terry Cheuk-Fung Yip Kashif M Munir Nowreen Haq Source Type: research
Correction to "Exenatide for weight-loss maintenance in adolescents with severe obesity: A randomized, placebo-controlled trial"
Obesity (Silver Spring). 2023 Aug 10. doi: 10.1002/oby.23843. Online ahead of print.NO ABSTRACTPMID:37559487 | DOI:10.1002/oby.23843 (Source: Obesity)
Source: Obesity - August 10, 2023 Category: Eating Disorders & Weight Management Source Type: research
Correction to "Exenatide for weight-loss maintenance in adolescents with severe obesity: A randomized, placebo-controlled trial"
Obesity (Silver Spring). 2023 Aug 10. doi: 10.1002/oby.23843. Online ahead of print.NO ABSTRACTPMID:37559487 | DOI:10.1002/oby.23843 (Source: Obesity)
Source: Obesity - August 10, 2023 Category: Eating Disorders & Weight Management Source Type: research
Correction to "Exenatide for weight-loss maintenance in adolescents with severe obesity: A randomized, placebo-controlled trial"
Obesity (Silver Spring). 2023 Aug 10. doi: 10.1002/oby.23843. Online ahead of print.NO ABSTRACTPMID:37559487 | DOI:10.1002/oby.23843 (Source: Obesity)
Source: Obesity - August 10, 2023 Category: Eating Disorders & Weight Management Source Type: research
Cost-effectiveness analysis of once-daily oral semaglutide versus placebo and subcutaneous glucagon-like peptide-1 receptor agonists added to insulin in patients with type 2 diabetes in China
Conclusion: We found that once-daily oral semaglutide, at a comparable price of semaglutide injection, proves to be a cost-effective add-on therapy to insulin for Chinese patients with T2DM, especially when compared to subcutaneous GLP-1 RAs other than injectable semaglutide and exenatide. However, to achieve cost-effectiveness in comparison to placebo, further cost reduction of oral semaglutide is necessary. The estimated annual cost of $1,711.03 for oral semaglutide demonstrates a more cost-effective option than placebo, highlighting its potential value in the management of T2DM. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 9, 2023 Category: Drugs & Pharmacology Source Type: research
Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis
In this study, we observed significant ferroptosis in NIT-1 cells and primary mouse islets after exposure to high glucose and palmitate (HG/PA). Compared to Exe and Sax, Met significantly alleviated glucolipotoxicity-induced pancreatic β cell ferroptosis. Blocking the activity of glutathione peroxidase 4 (GPX4) with Ras-selective lethal 3 or inhibiting its expression by small interfering RNA transfection significantly attenuated the anti-ferroptosis effects of Met. Mechanistically, Met alleviates HG/PA-induced β cell ferroptosis by regulating the GPX4/ACSL4 axis. Collectively, our findings highlight the significance of f...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Yue Sun Li-Qun Guo De-Guo Wang Yu-Jie Xing Ya-Ping Bai Teng Zhang Wen Wang Si-Min Zhou Xin-Ming Yao Jin-Han Cheng Wei-Wei Chang Kun Lv Chun-Xiao Li Xiang Kong Source Type: research
Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis
In this study, we observed significant ferroptosis in NIT-1 cells and primary mouse islets after exposure to high glucose and palmitate (HG/PA). Compared to Exe and Sax, Met significantly alleviated glucolipotoxicity-induced pancreatic β cell ferroptosis. Blocking the activity of glutathione peroxidase 4 (GPX4) with Ras-selective lethal 3 or inhibiting its expression by small interfering RNA transfection significantly attenuated the anti-ferroptosis effects of Met. Mechanistically, Met alleviates HG/PA-induced β cell ferroptosis by regulating the GPX4/ACSL4 axis. Collectively, our findings highlight the significance of f...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Yue Sun Li-Qun Guo De-Guo Wang Yu-Jie Xing Ya-Ping Bai Teng Zhang Wen Wang Si-Min Zhou Xin-Ming Yao Jin-Han Cheng Wei-Wei Chang Kun Lv Chun-Xiao Li Xiang Kong Source Type: research
