SIRT1-dependent deacetylation of Txnip H3K9ac is critical for exenatide-improved diabetic kidney disease
Biomed Pharmacother. 2023 Sep 22;167:115515. doi: 10.1016/j.biopha.2023.115515. Online ahead of print.ABSTRACTGlucagon-like peptide 1 receptor agonist exenatide (exendin-4) has potential protective capabilities against diabetic kidney disease (DKD). However, the underlying mechanism has not been fully elucidated. The expression of thioredoxin-interacting protein (Txnip) is upregulated during DKD progression by histone acetylation. Sirtuin 1 (SIRT1) is a deacetylase and is decreased in DKD, which indicates that it may regulate Txnip in this disease. Here, we used whole-body heterozygous Sirt1 knockout (Sirt1+/-) and kidney-...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 24, 2023 Category: Drugs & Pharmacology Authors: Mei-Jun Wang Xiang Cai Ri-Ying Liang En-Ming Zhang Xiao-Qi Liang Hua Liang Chang Fu An-Dong Zhou Yi Shi Fen Xu Meng-Yin Cai Source Type: research
SIRT1-dependent deacetylation of Txnip H3K9ac is critical for exenatide-improved diabetic kidney disease
Biomed Pharmacother. 2023 Sep 22;167:115515. doi: 10.1016/j.biopha.2023.115515. Online ahead of print.ABSTRACTGlucagon-like peptide 1 receptor agonist exenatide (exendin-4) has potential protective capabilities against diabetic kidney disease (DKD). However, the underlying mechanism has not been fully elucidated. The expression of thioredoxin-interacting protein (Txnip) is upregulated during DKD progression by histone acetylation. Sirtuin 1 (SIRT1) is a deacetylase and is decreased in DKD, which indicates that it may regulate Txnip in this disease. Here, we used whole-body heterozygous Sirt1 knockout (Sirt1+/-) and kidney-...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 24, 2023 Category: Drugs & Pharmacology Authors: Mei-Jun Wang Xiang Cai Ri-Ying Liang En-Ming Zhang Xiao-Qi Liang Hua Liang Chang Fu An-Dong Zhou Yi Shi Fen Xu Meng-Yin Cai Source Type: research
Alternate-day fat diet and exenatide modulate the brain leptin JAK2/STAT3/SOCS3 pathway in a fat diet-induced obesity and insulin resistance mouse model
CONCLUSIONS: In HFD caloric consumption, a combination of ADF and GLP-1 agonist enhances the brain leptin anorexigenic effect with the improvement of the metabolic sequelae of hyperinsulinemia, hyperlipidemia and liver steatosis.PMID:37732053 | PMC:PMC10507768 | DOI:10.5114/aoms/158534 (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Mona K Tawfik Dahlia I Badran Mohammed M Keshawy Samy Makary Mohamed Abdo Source Type: research
