Discerning Hope from Hype Related to Novo Nordisk Glucose-Responsive Insulin
Below is a copy of an investor report (seeHERE) on Novo Nordisk from the Wall Street investment bank known as Credit Suisse (the New York-based research business of the Swiss banking giant which mainly serves billionaire clients was formerly known as First Boston). I will discern my take-aways as it pertains to the few notes about Novo Nordisk ' s much-hyped (by the company itself) glucose-responsive insulin. There is some progress, but it is by no means a done deal.Novo Nordisk AS Feedback from London Post 3Q 2021 Management Meeting on ScribdOn November 4, 2021, Credit Suisse attended a London sell-side meeting with Novo ...
Source: Scott's Web Log - January 16, 2022 Category: Endocrinology Tags: Credit Suisse glucose responsive insulin Novo Nordisk Smart Insulin 2021 2022 SmartCells Source Type: blogs
ZERO tolerance for hypoglycemia
As more and more type 2 diabetics discover the Wheat Belly and other low-carb lifestyles, they are also discovering how rapidly and easily blood sugars drop.
As diabetics become less diabetic–a process that can occur VERY quickly, often within 24 hours of removing all wheat/grains from their diet–but they are taking insulin or certain diabetes drugs, there is potential for hypoglycemia or low blood sugar. Low blood sugar from diabetes drugs can be dangerous and should be avoided at all costs. (Imagine if a non-diabetic started administering insulin or blood sugar-reducing drugs–it would result in life-threate...
Source: Wheat Belly Blog - December 23, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates blood sugar diabetes undoctored wheat belly Source Type: blogs
For type 2 diabetes patients who require an injectable drug, GLP-1-based drugs are preferred over insulin
That's a pretty big change:Diabetes Guidelines Updated: For patients with type 2 diabetes who require an injectable drug, a glucagon-like peptide 1 receptor agonist is preferred over insulin.https://buff.ly/2T0KowcGlucagon-like peptide-1 (GLP-1)-based therapies (eg, GLP-1 receptor agonists, dipeptidyl peptidase-4 [DPP-4] inhibitors) affect glucose control throughseveral mechanisms, including:- enhancement of glucose-dependent insulin secretion- slowed gastric emptying- reduction of postprandial glucagon and food intakeThese agents do not usually cause hypoglycemia.Short-acting GLP-1 receptor agonists have an effect on post...
Source: Clinical Cases and Images - Blog - December 20, 2018 Category: Universities & Medical Training Tags: Diabetes Source Type: blogs
A (Belated) Tribute to David Mendosa
I still have some trouble coming to grips with the fact that on May 8, 2017, the Diabetes Community (D-OC) lost one of the Diabetes Online Community ' s true pioneers and I ' d say founders: David Mendosa (http://www.mendosa.com/ -- for the time being, anyway). David passed away following a diagnosis of angiosarcoma in the liver -- which is evidently a type of cancer. I think the fact that he passed away from something other than diabetes or its complications is a true testament to David ' s belief of living life to the fullest in spite of diabetes, which need not impede anyone, in spite of being dealt a pretty l...
Source: Scott's Web Log - August 17, 2017 Category: Endocrinology Tags: 2017 D-OC David Mendosa diabetes blogger diabetes industry Rick Mendosa Source Type: blogs
A (Belated) Tribute to David Mendosa
I still have some trouble coming to grips with the fact that on May 8, 2017, the Diabetes Community (D-OC) lost one of the Diabetes Online Community ' s true pioneers and I ' d say founders: David Mendosa (http://www.mendosa.com/ -- for the time being, anyway). David passed away following a diagnosis of angiosarcoma in the liver -- which is evidently a type of cancer. I think the fact that he passed away from something other than diabetes or its complications is a true testament to David ' s belief of living life to the fullest in spite of diabetes, which need not impede anyone, in spite of being dealt a pretty l...
Source: Scott's Web Log - August 17, 2017 Category: Endocrinology Tags: 2017 D-OC David Mendosa diabetes blogger diabetes industry Rick Mendosa Source Type: blogs
New Study Reports Diabetes Medication Could Treat Addiction
A relatively new class of drugs, glucagon-like peptide-1 (GLP-1) receptor agonists, have had much success in the treatment of type 2 diabetes. Now, these drugs may offer support in the treatment of addiction and drug abuse.
A new study, published in Translational Psychiatry, reports that GLP-1 receptors may be a target for treating drug abuse. The study was conducted in mice, but it calls attention to previous reports with similar findings.
Dopamine is essential to reward pathways that influence drug abuse and addiction. Endocannabinoids and arachidonic acid, which are also naturally present in the brain, affect the functi...
Source: World of Psychology - November 5, 2016 Category: Psychiatry & Psychology Authors: Psych Central Staff Tags: Addiction Brain Blogger Medications Publishers Recovery Research diabetes medication Dopamine Drug Abuse Drugs GLP-1 glucagon-like peptide-1 Jennifer Gibson PharmD study Translational Psychiatry Source Type: blogs
MKSAP: 66-year-old man with polyuria and polydipsia
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 66-year-old man is evaluated in the office after being treated in the emergency department for an exacerbation of chronic obstructive pulmonary disease. While in the emergency department, he was noted to have a random blood glucose level of 211 mg/dL (11.7 mmol/L). His HbA1c was 7.8% at the time. A repeat random fingerstick blood glucose level in office is 204 mg/dL (11.3 mmol/L).
The patient reports recent polyuria and polydipsia. He has lost 6 kg (13.2 lb) over the last 3 months. He has chronic epigastric pa...
Source: Kevin, M.D. - Medical Weblog - July 23, 2016 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Diabetes Endocrinology Source Type: blogs
ZERO TOLERANCE for hypoglycemia
Wheat elimination starts you powerfully on the path to reversing diabetes. We’ve seen it many times and it continues to develop in people who kiss their bagels, pretzels, and processed foods booby-trapped with wheat and grains goodbye.
But, as diabetics become less diabetic–a process that can occur VERY quickly, often within days of removing all wheat and grain products from their diet–but they are taking insulin or certain diabetes drugs, there is potential for hypoglycemia or low blood sugar. Low blood sugar from diabetes drugs can be dangerous and should be avoided at all costs. (Imagine if a non-diabetic started ...
Source: Wheat Belly Blog - April 2, 2016 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle diabetes glucose gluten grains hypoglycemia insulin Source Type: blogs
Nature’s Medicine Cabinet
More than 70 percent of new drugs approved within the past 30 years originated from trees, sea creatures and other organisms that produce substances they need to survive. Since ancient times, people have been searching the Earth for natural products to use—from poison dart frog venom for hunting to herbs for healing wounds. Today, scientists are modifying them in the laboratory for our medicinal use. Here’s a peek at some of the products in nature’s medicine cabinet.
A protein called draculin found in the saliva of vampire bats is in the last phases of clinical testing as a clot-buster for stroke patients. Vampire b...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 14, 2015 Category: Research Authors: Srivalli Subbaramaiah Tags: Chemistry and Biochemistry Pharmacology Cool Creatures Diseases Medicines Natural Products Source Type: blogs
Funtabulously Frivolous Friday Five 106
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia…introducing Funtabulously Frivolous Friday Five 106Question 1Which drug is derived from the saliva of the Gila Monster+ Reveal the Funtabulous Answerexpand(document.getElementById('ddet699757968'));expand(document.getElementById('ddetlink699757968'))ExenatideThe hormone exendin-4 occurs naturally in the saliva of the Gila monster, a large venomous lizard native to the southwestern United States and northwestern Mexico.Exenatide is a glucagon-like peptide-1 agonist (GLP-...
Source: Life in the Fast Lane - April 30, 2015 Category: Emergency Medicine Authors: Niall Hamilton Tags: Frivolous Friday Five LITFL FFFF Source Type: blogs
Mary figured out how to reverse diabetes . . . on her own
Mary shared her story of how she learned–on her own, at first–that foods that raise blood sugar, such as grains, cause you to “need” diabetes drugs. Not eating foods that raise blood sugar causes you to not need diabetes drugs.
“I started going grain-free in December, 2014 as a last-ditch effort to get a handle on my diabetes.
“My extreme reaction to metformin–stomach problems from diarrhea to esophageal spasms–made me give it up for good early last year. My blood sugars were out of control, but my doctor did not want to start me on insulin. My blood sugar numbers were regu...
Source: Wheat Belly Blog - April 16, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories blood sugar diabetes gluten grains Weight Loss Source Type: blogs
If you have diabetes: NO low blood sugars!
Wheat elimination starts you powerfully on the path to reversing diabetes. We’ve seen it many times and it continues to develop in people who kiss their bagels, pretzels, and processed foods booby-trapped with wheat goodbye.
But, as diabetics become less diabetic–a process that can occur VERY quickly, often within days of removing all wheat products from their diet–but they are taking insulin or certain diabetes drugs, there is potential for hypoglycemia or low blood sugar. Low blood sugar from diabetes drugs can be dangerous and should be avoided at all costs. (Imagine if a non-diabetic started administ...
Source: Wheat Belly Blog - March 28, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle blood sugar diabetes gluten grains hypoglycemia Source Type: blogs
Doing Your Own Research
By David Spero
Doctors used to be the only source of medical information. Not anymore. You can get much of the same information on the Internet. Problem is, not all of the information you'll come across online is good. Here are some ways to empower yourself with good Internet research:
• It's good to have some general "search engine" sites as a starting point on your quest for information. I usually start with Google. Yahoo and Bing are also good. Search engine sites will give you a list of more specific sites where you can get the information you seek.
For example, a Google search for "diabetes" gives over 70 milli...
Source: Diabetes Self-Management - August 6, 2014 Category: Diabetes Authors: David Spero Source Type: blogs
The Safety of Diabetes Drugs
A possible connection between one of our newest and most important classes of diabetes drugs and pancreatic cancer has frightened many of us. But people with diabetes can now breathe easier.
The United States Food and Drug Administration and its European counterpart just released their joint findings concluding that these drugs, which include Byetta, Victoza, Bydureon, and Januvia, have “no compelling evidence of an increased... (Source: David Mendosa's SharePosts)
Source: David Mendosa's SharePosts - March 5, 2014 Category: Diabetes Authors: David Mendosa Source Type: blogs
Little-Noticed Diabetes Care Developments of 2013
As we approach the new year (2014!), although I haven't blogged as much as I did a number of years ago, there were a few things which, in my opinion, deserve acknowledgement as they relate to diabetes care. One of the biggest (perhaps), yet less acknowledged, developments was mergers and acquisitions in the diabetes care space. Although I follow this stuff, sometimes even I lose track of who acquired who and what their new names are (when they change the name of the company).Bristol Myers Squibb: In Again, Out Again (... Of Diabetes Care, That Is). Novo's Danish Delusions.My readers may recall that last y...
Source: Scott's Web Log - January 1, 2014 Category: Diabetes Tags: 2013 2014 Annual Review AstraZeneca Bristol Myers Squibb CanAm FDA JDRF Lilly Medtronic NIDDK NIH Nipro Novo Nordisk Teva Wal-Mart Source Type: blogs
