Dissipation pattern and safety assessment of fenazaquin and metaflumizone in butterbur ( < em > Petasites japonicus < /em > )
This study was conducted to investigate the residual behavior and safety assessment of fenazaquin and metaflumizone in butterbur. The samples were periodically harvested, extracted using QuEChERS method, and determined by LC-MS/MS. The linearity of matrix-matched calibration curve was ≥0.99 for both compounds. The average recoveries of fenazaquin and metaflumizone at two fortification levels (0.01 and 0.1 mg kg-1) ranged from 86.6 to 97.2%. The relative standard deviation was <10%. After 7 days, the fenazaquin and metaflumizone initial residues in butterbur were dissipated to 79 and 78%, with the respective half-lives...
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - April 10, 2023 Category: Environmental Health Authors: Syed Wasim Sardar Abd Elaziz Sulieman Ahmed Ishag Jeong Yoon Choi Yeong Ju Jo Hun Ju Ham Source Type: research
Dissipation pattern and safety assessment of fenazaquin and metaflumizone in butterbur ( < em > Petasites japonicus < /em > )
This study was conducted to investigate the residual behavior and safety assessment of fenazaquin and metaflumizone in butterbur. The samples were periodically harvested, extracted using QuEChERS method, and determined by LC-MS/MS. The linearity of matrix-matched calibration curve was ≥0.99 for both compounds. The average recoveries of fenazaquin and metaflumizone at two fortification levels (0.01 and 0.1 mg kg-1) ranged from 86.6 to 97.2%. The relative standard deviation was <10%. After 7 days, the fenazaquin and metaflumizone initial residues in butterbur were dissipated to 79 and 78%, with the respective half-lives...
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - April 10, 2023 Category: Environmental Health Authors: Syed Wasim Sardar Abd Elaziz Sulieman Ahmed Ishag Jeong Yoon Choi Yeong Ju Jo Hun Ju Ham Source Type: research
Allergies and Natural Alternatives
Complementary and integrative medicine therapies in the treatment of allergy and allergic rhinitis (AR) are divided broadly into the categories of nutritional supplements, herbal supplements, Ayurvedic, and Chinese traditional medicine. Some therapies are likely completely safe, such as Manuka honey, with no known side effects. Others have significant risks, such as ephedra, which was ultimately banned for use by the Food and Drug Administration. The efficacy of these therapies is varied and under-researched. The therapies with the strongest evidence in the treatment of allergy and AR are Manuka honey, butterbur, and Sinup...
Source: Otolaryngologic clinics of North America - September 7, 2022 Category: ENT & OMF Authors: Walter M. Jongbloed, Seth M. Brown Source Type: research
Synergistic immunosuppressive effect of hispidulin and nepetin mixtures on human T lymphocytes
CONCLUSIONS: The optimized mixture of His and Nep at 66.7:200 µM is suggested for further study due to a greater suppressive effect than a single compound or a naturally-occurring dose.PMID:35549795 | DOI:10.1080/08923973.2022.2077216 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 13, 2022 Category: Allergy & Immunology Authors: Premrutai Thitilertdecha Varangkana Tantithavorn Poonsin Poungpairoj Nattawat Onlamoon Source Type: research
Synergistic immunosuppressive effect of hispidulin and nepetin mixtures on human T lymphocytes
CONCLUSIONS: The optimized mixture of His and Nep at 66.7:200 µM is suggested for further study due to a greater suppressive effect than a single compound or a naturally-occurring dose.PMID:35549795 | DOI:10.1080/08923973.2022.2077216 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 13, 2022 Category: Allergy & Immunology Authors: Premrutai Thitilertdecha Varangkana Tantithavorn Poonsin Poungpairoj Nattawat Onlamoon Source Type: research
Petasites for Migraine Prevention: New Data on Mode of Action, Pharmacology and Safety. A Narrative Review
Petasins are the pharmacologically active ingredients of butterbur and of therapeutic benefit in the treatment of migraine and tension headaches. Here, we summarize the pharmacology, safety and clinical efficacy of butterbur in the prevention of migraine attacks and present new data on its mode of action. We review published literature and study reports on the safety and clinical efficacy of the butterbur root extract Petadolex® and report new findings on petasins in dampening nociception by desensitizing calcium-conducting TRP ion channels of primary sensory neurons. Importantly, butterbur diminishes the production of in...
Source: Frontiers in Neurology - April 26, 2022 Category: Neurology Source Type: research
Anti-inflammatory efficacy of petasin-incorporated zinc oxide eugenol sealer & #8211; An in vivo zebrafish study
Conclusion: The addition of petasin extract to ZnOE reduces the inflammation potential of ZnOE sealers. ZnOE sealer containing eugenol and petasin in the ratio of 1:1 showed a maximal reduction in inflammation. (Source: Journal of Conservative Dentistry)
Source: Journal of Conservative Dentistry - April 1, 2022 Category: Dentistry Authors: Selvanathan M J. Vinola Kittappa Karthikeyan Apoorva Sharma Sai Sudheshna Mahalaxmi Sekar Source Type: research
Impact of the clinically approved Petasites hybridus extract Ze 339 on intestinal mechanisms involved in the handling of histamine
In conclusion, we report an effect of Ze 339 on transcellular histamine transport, where inhibition of OCT3 may contribute.PMID:35149385 | DOI:10.1016/j.biopha.2022.112698 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 12, 2022 Category: Drugs & Pharmacology Authors: Lina G Mettler Karin Brecht Veronika Butterweck Henriette E Meyer Zu Schwabedissen Source Type: research
Impact of the clinically approved Petasites hybridus extract Ze 339 on intestinal mechanisms involved in the handling of histamine
In conclusion, we report an effect of Ze 339 on transcellular histamine transport, where inhibition of OCT3 may contribute.PMID:35149385 | DOI:10.1016/j.biopha.2022.112698 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 12, 2022 Category: Drugs & Pharmacology Authors: Lina G Mettler Karin Brecht Veronika Butterweck Henriette E Meyer Zu Schwabedissen Source Type: research
Petasin is the main component responsible for the anti-adipogenic effect of Petasites japonicus
Fitoterapia. 2022 Jan 18;157:105130. doi: 10.1016/j.fitote.2022.105130. Online ahead of print.ABSTRACTPetasites japonicus is one of the most popular edible wild plants in Japan. Many biological effects of P. japonicus have been reported, including anti-allergy, anti-inflammation, and anticancer effects. Although its anti-obesity effect has been reported in several studies, the most important component responsible for this activity has not been fully elucidated. On screening the components that suppress adipocyte differentiation in 3T3-F442A cells, we found that the extract of the flower buds of P. japonicus has anti-adipog...
Source: Fitoterapia - January 20, 2022 Category: Biochemistry Authors: Shota Uesugi Mayuka Hakozaki Yuko Kanno Akiko Shiraishi Mizuki Suzuki Ken-Ichi Kimura Yoshihito Shiono Akira Yano Source Type: research
Petasin is the main component responsible for the anti-adipogenic effect of Petasites japonicus
Fitoterapia. 2022 Jan 17:105130. doi: 10.1016/j.fitote.2022.105130. Online ahead of print.ABSTRACTPetasites japonicus is one of the most popular edible wild plants in Japan. Many biological effects of P. japonicus have been reported, including anti-allergy, anti-inflammation, and anticancer effects. Although its anti-obesity effect has been reported in several studies, the most important component responsible for this activity has not been fully elucidated. On screening the components that suppress adipocyte differentiation in 3 T3-F442A cells, we found that the extract of the flower buds of P. japonicus has anti-adipogeni...
Source: Fitoterapia - January 20, 2022 Category: Biochemistry Authors: Shota Uesugi Mayuka Hakozaki Yuko Kanno Akiko Shiraishi Mizuki Suzuki Ken-Ichi Kimura Yoshihito Shiono Akira Yano Source Type: research
Viruses, Vol. 14, Pages 106: The Petasites hybridus CO2 Extract (Ze 339) Blocks SARS-CoV-2 Replication In Vitro
In conclusion, Ze 339 as well as the petasins potently inhibited SARS-CoV-2 replication in vitro of the Wuhan and Delta variants. Since time is of essence in finding effective treatments, clinical studies will have to demonstrate if Ze339 can become a therapeutic option to treat SARS-CoV-2 infections. (Source: Viruses)
Source: Viruses - January 7, 2022 Category: Virology Authors: Lorena Urda Matthias Heinrich Kreuter J ürgen Drewe Georg Boonen Veronika Butterweck Thomas Klimkait Tags: Article Source Type: research
Aqueous extract of < em > Petasites japonicus < /em > leaves promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells
CONCLUSIONS: These results suggest that AL can regulate osteoblasts differentiation, at least in part through Runx2 and Osterix. Therefore, it is highly likely that P. japonicus will be useful as an alternate therapeutic for the prevention and treatment of osteoporosis.PMID:34603606 | PMC:PMC8446688 | DOI:10.4162/nrp.2021.15.5.579 (Source: Cell Research)
Source: Cell Research - October 4, 2021 Category: Cytology Authors: Eun Ji Kim Jae In Jung Young Eun Jeon Hyun Sook Lee Source Type: research
