Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology
Conclusion Scientific proof of the benefit of phytotherapy in otorhinolaryngology remains to be established but, given its widespread use and the reported data, knowledge of this form of treatment needs to be developed. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - November 30, 2016 Category: ENT & OMF Source Type: research
Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.
Abstract
Leukemia has been the third type of cancer killing many people across the world. Bakkenolide A (Bak), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation. And increasing evidences suggest that histone deacetylase 3 (HDAC3) plays vital roles in cancer formation and persistence via cell death, apoptosis and inflammation. But the function of Bakkenolide A in regulating leukemia is not understood yet, particularly via HDAC3. Here, we found that HDAC3 is up-regulated in clinical samples of leukemia compared with a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 10, 2016 Category: Drugs & Pharmacology Authors: Zhang L, Hong Z, Zhang RR, Sun XZ, Yuan YF, Hu J, Wang X Tags: Biomed Pharmacother Source Type: research
Nutraceuticals in Migraine: A Summary of Existing Guidelines for Use
ConclusionThis review serves to provide a summary of existing guidelines for the use of certain nutraceuticals including riboflavin, coenzyme Q10, magnesium, butterbur, feverfew, and omega‐3 polyunsaturated fatty acids. The review will also discuss the regulation of nutraceuticals in North America and the current controversy regarding butterbur and its safety. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - March 7, 2016 Category: Neurology Authors: Thilinie Rajapakse, Tamara Pringsheim Tags: Headache Currents Source Type: research
Nutraceuticals in Migraine: A Summary of Existing Guidelines for Use.
CONCLUSION: This review serves to provide a summary of existing guidelines for the use of certain nutraceuticals including riboflavin, coenzyme Q10, magnesium, butterbur, feverfew, and omega-3 polyunsaturated fatty acids. The review will also discuss the regulation of nutraceuticals in North America and the current controversy regarding butterbur and its safety.
PMID: 26954394 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - March 7, 2016 Category: Neurology Authors: Rajapakse T, Pringsheim T Tags: Headache Source Type: research
Nutraceuticals in Acute and Prophylactic Treatment of Migraine
Opinion statement
People who suffer from headaches often prefer nutraceutical treatment over traditional pharmacological approaches, due to fear of possible side effects, drug dependence, or addiction. Since treatment with nutraceuticals does not require a doctor’s prescription, many patients rely on their own judgment as to when and which one to take, often without consultation or guidance from their physician. Some physicians could provide information about potential efficacy and side effects of various products, but many are not familiar with the nutraceuticals. Widespread skepticism persists among...
Source: Current Treatment Options in Neurology - February 29, 2016 Category: Neurology Source Type: research
Sesquiterpenoids from an edible plant Petasites japonicus and their promoting effects on neurite outgrowth
Publication date: April 2016 Source:Journal of Functional Foods, Volume 22 Author(s): Jing Xu, Feifei Ji, Xiangrong Cao, Jun Ma, Yasushi Ohizumi, Dongho Lee, Yuanqiang Guo Petasites japonicus (Sieb. & Zucc.) Maxim., belonging to the Compositae family, is a perennial herb and has been consumed as a wild vegetable. Our survey on the chemical composition of P. japonicus resulted in the isolation of two new and seventeen known sesquiterpenoids. Their structures were elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopic data analysis, and the absolute configurations of the new co...
Source: Journal of Functional Foods - February 5, 2016 Category: Nutrition Source Type: research
Complementary and Integrative Approaches for Pediatric Headache
In this article, the use of complementary and integrative medicine for the management of pediatric headache is reviewed. Despite limited numbers of studies for pediatric headaches, children and families seek these services. Integrative medicine focuses on treating the whole person, integrating conventional medicine with mind-body-spirit methods. Nutriceuticals include dietary supplements in the form of vitamins and minerals, and a review of magnesium, CoQ10, butterbur and melatonin in pediatric headache is presented here. (Source: Seminars in Pediatric Neurology)
Source: Seminars in Pediatric Neurology - January 29, 2016 Category: Neurology Authors: Sita Kedia Source Type: research
Complementary and Integrative Approaches for Pediatric Headache
In this article, the use of complementary and integrative medicine for the management of pediatric headache is reviewed. Despite limited numbers of studies for pediatric headaches, children and families seek these services. Integrative medicine focuses on treating the whole person, integrating conventional medicine with mind-body-spirit methods. Nutriceuticals include dietary supplements in the form of vitamins (vitamin D), minerals (magnesium), coenzyme Q, butterbur, and melatonin. Acupuncture, stimulation, physical therapy and Transcutaneous Electrical Nerve Stimulations (TENS) or Transcranial Magnetic Stimulation (TMS) ...
Source: Seminars in Pediatric Neurology - January 28, 2016 Category: Neurology Authors: Sita Kedia Source Type: research
A novel eremophilane lactone inhibits FcεRI-dependent release of pro-inflammatory mediators: structure-dependent bioactivity
Conclusions
These results indicate that F-1a inhibits degranulation of RBL-2H3 cells activated via the high affinity IgE receptor, FcεRI, and that this effect is dependent upon hydroxylation of the third carbon. (Source: Inflammation Research)
Source: Inflammation Research - January 20, 2016 Category: Research Source Type: research
Prophylactic Drug Treatment of Migraine in Children and Adolescents: An Update
Abstract
Migraine as a highly disabling pain condition influences the daily activities of those affected, including children and adolescents. The pathomechanism of migraine is not fully understood, and the different types of prophylactic antimigraine drugs that are applied are not specific for migraine. There is a need for preventive treatment in the event of frequent migraine attacks, an impairment of the quality of life, severe accompanying or aura symptoms, and the failure of acute drug treatment. The following pharmacological classes are recommended: antidepressants, antiepileptics, antihistamines, ...
Source: Current Pain and Headache Reports - December 22, 2015 Category: Neurology Source Type: research
Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity
Conclusion Petatewalide B from Petasites genus not only has anti-allergic and anti-inflammatory effects but also induces a transient increase of membrane potential in C6 glioma cells. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 15, 2015 Category: Drugs & Pharmacology Source Type: research
Recent Patents of Complementary and Alternative Medicine for Allergic Rhinitis.
Authors: Hon KL, Fung CK, Leung AK, Lam HS, Lee SL
Abstract
Allergic rhinitis (AR) is a common respiratory disease affecting both adults and children worldwide. Affected patients may experience nasal congestion/stuffiness, rhinorrhea (anterior and/or posterior), nasal/nasopharyngeal itching and sneezing. Allergen avoidance is the principal step in the management. Nasal saline irrigation to remove allergen (s) in the nose is a useful adjunctive therapy in the management of moderate to severe AR. Symptomatic relief and improved quality of life may be achieved in the majority of patients with appropriate phar...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - November 20, 2015 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Molecules, Vol. 20, Pages 15033-15048: Inhibition of Cytosolic Phospholipase A2α (cPLA2α) by Medicinal Plants in Relation to Their Phenolic Content
This study provides evidence that cPLA2α may be a relevant target for anti-inflammatory agents. (Source: Molecules)
Source: Molecules - August 17, 2015 Category: Chemistry Authors: Eva ArnoldThorsten BenzCornelia ZappMichael Wink Tags: Article Source Type: research
Nutraceutical and Other Modalities for the Treatment of Headache
This article summarizes the evidence for the use of these therapies with discussion on evidence quality and product controversies.
Recent Findings:: The evidence for the use of nutraceuticals is low or conflicting. For migraine prevention in adults, Level B evidence, at best, exists for the use of feverfew, magnesium, and riboflavin (vitamin B2). Level C evidence exists for coenzyme Q10 (CoQ10) and Level U evidence for melatonin. While Level A evidence exists for the use of Petasites, caution should be exercised given the potential for hepatic toxicity. The evidence level for IV magnesium for acute migraine treatment is B ...
Source: CONTINUUM - August 1, 2015 Category: Neurology Tags: Review Articles Source Type: research
Preventive Migraine Treatment
This article reviews the evidence base for the preventive treatment of migraine.
Recent Findings:: Evidence-based guidelines for the preventive treatment of migraine have recently been published by the American Academy of Neurology (AAN) and the Canadian Headache Society (CHS), providing valuable guidance for clinicians. Strong evidence exists to support the use of metoprolol, timolol, propranolol, divalproex sodium, sodium valproate, and topiramate for migraine prevention, according to the AAN. Based on best available evidence, adverse event profile, and expert consensus, topiramate, propranolol, nadolol, metoprolol, amit...
Source: CONTINUUM - August 1, 2015 Category: Neurology Tags: Review Articles Source Type: research
