Inhibition of SARS-CoV-2 infection and replication by Petasites hybridus CO2-extract (Ze 339)
CONCLUSION: Thereby, Ze 339 attenuated epithelial infection by SARS-CoV-2 and modeled the IFN response. In conclusion, this study highlights Ze 339 as a potential treatment option for COVID-19 that limits infection-associated cell intrinsic immune responses.PMID:38061134 | DOI:10.1016/j.biopha.2023.115959 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2023 Category: Drugs & Pharmacology Authors: Constanze A Jakwerth Vincent Grass Anna Erb Andreas Pichlmair Georg Boonen Veronika Butterweck Carsten B Schmidt-Weber Source Type: research
Application to Butterbur Products of a Suggested Daily Intake-Based Safety Evaluation of Individual Herbal Supplements with Cytochrome P450 Expression as a Major Index
J Nutr Sci Vitaminol (Tokyo). 2023;69(3):206-219. doi: 10.3177/jnsv.69.206.ABSTRACTThe present paper first proposes a method for ensuring the safety of commercial herbal supplements, termed the suggested daily intake-based safety evaluation (SDI-based safety evaluation). This new method was inspired as a backward analog of the acceptable daily intake (ADI) derivation from the no observed adverse effect level (NOAEL), the basis of food additive risk analysis; namely, rats are dosed with individual herbal supplement products at the SDI for human use multiplied by 100 (the usual uncertainty factor value) per body weight for 8...
Source: Journal of Nutritional Science and Vitaminology - July 2, 2023 Category: Nutrition Authors: Hiroko Hashida Misaki Kurawaka Haruka Tatehana Anna Arita Naho Sasaki Fumio Shimura Yuko Yamazaki Source Type: research
