Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, ...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: Thatcha Yimthin Rungnapa Phunpang Shelton W Wright Ekkachai Thiansukhon Seksan Chaisuksant Ploenchan Chetchotisakd Kittisak Tanwisaid Somchai Chuananont Chumpol Morakot Narongchai Sangsa Wirayut Silakun Sunee Chayangsu Noppol Buasi Ganjana Lertmemongkolch Source Type: research
The accumulation of active ingredients of Polygonatum cyrtonema Hua is associated with soil characteristics and bacterial community
ConclusionThe study demonstrated that bacterial microorganisms were involved in the accumulation of active ingredients of P. cyrtonema together with soil physicochemical properties and enzyme activities, which provided a theoretical basis for the scientific and effective artificial cultivation of high-quality P. cyrtonema. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 15, 2024 Category: Microbiology Source Type: research
Challenges and mitigation strategies associated with Burkholderia cepacia complex contamination in pharmaceutical manufacturing
Arch Microbiol. 2024 Mar 14;206(4):159. doi: 10.1007/s00203-024-03921-9.ABSTRACTBurkholderia cepacia complex (BCC) is a Gram-negative, non-spore-forming bacterium with more than 20 opportunistic pathogenic species, most commonly found in soil and water. Due to their rapid mutation rates, these organisms are adaptable and possess high genomic plasticity. BCC can cause life-threatening infections in immunocompromised individuals, such as those with cystic fibrosis, chronic granulomatous disease, and neonates. BCC contamination is a significant concern in pharmaceutical manufacturing, frequently causing non-sterile product re...
Source: Archives of Microbiology - March 14, 2024 Category: Microbiology Authors: Sethuraman Prem Kumar Karupanagounder Thangaraj Uthra Vellapandian Chitra Narayanasamy Damodharan Gururaja Perumal Pazhani Source Type: research
Impact of template denaturation prior to whole genome amplification on gene detection in high GC-content species, Burkholderia mallei and B. pseudomallei
In this study, we sought to determine the types and prevalence of antimicrobial resistance determinants (ARDs) in Burkholderia spp. strains using the Antimicrobial Resistance Determinant Microarray (ARDM). (Source: BMC Research Notes)
Source: BMC Research Notes - March 12, 2024 Category: Research Authors: Chris R. Taitt, Tomasz A. Leski, Jaimee R. Compton, Amy Chen, Kimberly L. Berk, Robert W. Dorsey, Shanmuga Sozhamannan, Dianne L. Dutt and Gary J. Vora Tags: Research Note Source Type: research
A < em > Burkholderia stabilis < /em > outbreak associated with the use of ultrasound gel in multiple healthcare centres in Montr éal, Canada, May-October 2021
CONCLUSION: Contaminated non-sterile gel caused infections and pseudo-infections in several patients.PMID:38455880 | PMC:PMC10917130 | DOI:10.14745/ccdr.v49i78a03 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Christine Arsenault Jos ée Harel Florence Doualla-Bell Yiorgos Alexandros Cavayas Xavier Marchand-S énécal Charles Frenette Yves Longtin Linda Lalande L Marie-Paule Diby Nadia Desmarais Source Type: research
A < em > Burkholderia stabilis < /em > outbreak associated with the use of ultrasound gel in multiple healthcare centres in Montr éal, Canada, May-October 2021
CONCLUSION: Contaminated non-sterile gel caused infections and pseudo-infections in several patients.PMID:38455880 | PMC:PMC10917130 | DOI:10.14745/ccdr.v49i78a03 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Christine Arsenault Jos ée Harel Florence Doualla-Bell Yiorgos Alexandros Cavayas Xavier Marchand-S énécal Charles Frenette Yves Longtin Linda Lalande L Marie-Paule Diby Nadia Desmarais Source Type: research
A < em > Burkholderia stabilis < /em > outbreak associated with the use of ultrasound gel in multiple healthcare centres in Montr éal, Canada, May-October 2021
CONCLUSION: Contaminated non-sterile gel caused infections and pseudo-infections in several patients.PMID:38455880 | PMC:PMC10917130 | DOI:10.14745/ccdr.v49i78a03 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Christine Arsenault Jos ée Harel Florence Doualla-Bell Yiorgos Alexandros Cavayas Xavier Marchand-S énécal Charles Frenette Yves Longtin Linda Lalande L Marie-Paule Diby Nadia Desmarais Source Type: research
