Layering vaccination with antibiotic therapy results in protection and clearance of Burkholderia pseudomallei in Balb/c mice
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - January 30, 2024 Category: Infectious Diseases Authors: Kay B. BarnesPaul BrettMary BurtnickAndreas VenteChristine BentleyMark I. RichardsHelen C. Flick-SmithGary BurgessJoanne E. ThwaiteThomas R. LawsThomas C. MaishmanMichelle NelsonSarah V. Harding1Defence Science and Technology Laboratory, Porton Down, Sali Source Type: research
Molecules, Vol. 29, Pages 628: Experimental and Computational Analysis of Synthesis Conditions of Hybrid Nanoflowers for Lipase Immobilization
ide M. F. Soares
This work presents a framework for evaluating hybrid nanoflowers using Burkholderia cepacia lipase. It was expanded on previous findings by testing lipase hybrid nanoflowers (hNF-lipase) formation over a wide range of pH values (5–9) and buffer concentrations (10–100 mM). The free enzyme activity was compared with that of hNF-lipase. The analysis, performed by molecular docking, described the effect of lipase interaction with copper ions. The morphological characterization of hNF-lipase was performed using scanning electron microscopy. Fourier Transform Infrared Spectroscopy...
Source: Molecules - January 29, 2024 Category: Chemistry Authors: Danivia Endi S. Souza Lucas M. F. Santos Jo ão P. A. Freitas Lays C. de Almeida Jefferson C. B. Santos Ranyere Lucena de Souza Matheus M. Pereira Álvaro S. Lima Cleide M. F. Soares Tags: Article Source Type: research
Novel Approaches to Multidrug-Resistant Infections in Cystic Fibrosis
Patients with cystic fibrosis (CF) often develop respiratory tract infections with pathogenic multidrug-resistant organisms (MDROs) such as methicillin-resistant Staphylococcus aureus, and a variety of gram-negative organisms that include Pseudomonas aeruginosa, Burkholderia sp., Stenotrophomonas maltophilia, Achromobacter xylosoxidans, and nontuberculous mycobacteria (NTM). Despite the introduction of new therapies to address underlying cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction, MDRO infections remain a problem and novel antimicrobial interventions are still needed. Therapeutic approaches incl...
Source: Infectious Diseases Clinics of North America - January 26, 2024 Category: Infectious Diseases Authors: Thomas S. Murray, Gail Stanley, Jonathan L. Koff Source Type: research
Extent and Resistance Patterns of Gram-negative Bacteria Isolated From 13 Hospitals in Shaoxing, Zhejiang Province
New Microbiol. 2024 Jan;46(4):340-347.ABSTRACTGram-negative bacteria are increasingly recognized as the sauce of severe infections. In recent years, epidemiological data has indicated that the drug resistance rate of Gram-negative bacteria has significantly increased. We analyzed the epidemiological surveillance data of gram-negative bacteria in Shaoxing City in 2021 by retrospectively collecting drug susceptibility data of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Burkholderia cepacian from thirteen tertiary hospitals. A total of ...
Source: New Microbiologica - January 22, 2024 Category: Microbiology Authors: Yiqing Zhou Meichun Liang Xiaojiao Zhang Qiuli He Li Lv Guofeng Mao Source Type: research
