Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells
CONCLUSION: LAF exerts antitumor effects via S phase arrest by activating CDKN1C/p57 in colorectal cancer cells.PMID:36708218 | DOI:10.1080/13880209.2023.2172048 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - January 28, 2023 Category: Drugs & Pharmacology Authors: Rui-Yi Yang Jia-Yi Tan Zhe Liu Xiao-Ling Shen Ying-Jie Hu Source Type: research
Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine
Biomed Pharmacother. 2022 Dec 12;158:114104. doi: 10.1016/j.biopha.2022.114104. Online ahead of print.NO ABSTRACTPMID:36516694 | DOI:10.1016/j.biopha.2022.114104 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 14, 2022 Category: Drugs & Pharmacology Authors: Nermeen Yosri Sultan M Alsharif Jianbo Xiao Syed G Musharraf Chao Zhao Aamer Saeed Ruichang Gao Noha S Said Alessandro Di Minno Maria Daglia Zhiming Guo Shaden A M Khalifa Hesham R El-Seedi Source Type: research
Viruses, Vol. 14, Pages 2511: Weed Hosts Represent an Important Reservoir of Turnip Yellows Virus and a Possible Source of Virus Introduction into Oilseed Rape Crop
umar Kundu
Turnip yellows virus (TuYV) is one of the most important pathogens of oilseed rape worldwide. The virus has a large host range including many crop species (e.g., oilseed rape, pea, chickpea) and weeds from more than twenty plant families. Other than oilseed rape, we detected TuYV in many commonly grown weed species that share the fields and vegetation period together with canola crops in Czech and Slovak Republics. TuYV was detected by reverse-transcription polymerase chain reaction (RT-PCR) in at least 26 species including main crop hosts (oilseed rape), intercrops and weeds such as Amaranthus retroflexus, ...
Source: Viruses - November 13, 2022 Category: Virology Authors: Lucie Slav íková Emad Ibrahim Glenda Alquicer Jana Toma šechová Katar ína Šoltys Miroslav Glasa Jiban Kumar Kundu Tags: Communication Source Type: research
Drug-Induced Liver Injury from Herbal Liver Detoxification Tea
We describe the case of a 36-year-old female who developed a clinically significant acute liver injury with a cholestatic pattern due to an over-the-counter herbal liver detox tea. This is the first case reported of a hepatotoxic effect from any of these compounds or ingredients in the detox tea: burdock root, stinging nettle leaf, cleavers herb, dandelion root, lemon peel, and lemon myrtle leaf (Backhousia citriodora). Idiosyncratic drug-induced liver injury (DILI) remains poorly understood; however, recognizing potential toxins is imperative to understanding toxicogenomics and identifying those at risk.Case Rep Gastroent...
Source: Case Reports in Gastroenterology - November 8, 2022 Category: Gastroenterology Source Type: research
Abundant and diverse endophytic bacteria associated with medicinal plant Arctium lappa L. and their potential for host plant growth promoting
This study demonstrated that A. lappa L. harbors abundant endophytic bacteria, and some endophytic bacteria showed good potential for the development of microbial fertilizer in the future.PMID:36284037 | DOI:10.1007/s10482-022-01785-x (Source: Antonie van Leeuwenhoek)
Source: Antonie van Leeuwenhoek - October 25, 2022 Category: Microbiology Authors: Jia-Qi Liu Shu-Mei Chen Chun-Mei Zhang Ming-Jie Xu Ke Xing Cheng-Guo Li Kui Li Yu-Qin Zhang Sheng Qin Source Type: research
Phytochemicals and biological activities of burdock (Arctium lappa L.) extracts: A review
Chem Biodivers. 2022 Oct 5. doi: 10.1002/cbdv.202200615. Online ahead of print.ABSTRACTArctium lappa L., also known as burdock, is an edible wild plant which has the ability to grow in distinct environments and is considered a weed in several parts of the world. This species has great value in the biological and medical fields with its major secondary components being phenolic compounds and terpenes, substances rich in desired biological activities as antioxidant, antimicrobial, antitumor and anti-inflammatory. In addition, burdock leaves extracts have shown a modulatory effect on the complement system, which plays an impo...
Source: Chemistry and Biodiversity - October 5, 2022 Category: Biochemistry Authors: Ari ádine Reder Custodio de Souza Thais Latansio de Oliveira Pamela Fontana Milena Carvalho Carneiro Marcos L úcio Corazza Iara Jose de Messias Reason Lorena Bavia Source Type: research
Arctium lappa leaves based on network pharmacology and experimental validation attenuate atherosclerosis by targeting the AMPK-mediated PPARG/LXR α pathway
In conclusion, A. lappa leaves attenuated AS-induced cholesterol accumulation by targeting the AMPK-mediated PPARG/LXRα pathway and promoting cholesterol efflux.PMID:36076592 | DOI:10.1016/j.biopha.2022.113503 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2022 Category: Drugs & Pharmacology Authors: Mengmeng Wang Bingdi Cui Man Gong Qiuyan Liu Xingxu Zhuo Jiangnan Lv Lianhe Yang Xiaoqian Liu Zhimin Wang Liping Dai Source Type: research
Chlorogenic acid: A dietary phenolic acid with promising pharmacotherapeutic potential
Curr Med Chem. 2022 Aug 16. doi: 10.2174/0929867329666220816154634. Online ahead of print.ABSTRACTPhenolic acids are now receiving a great deal of interest as pervasive human dietary constituents that have various therapeutic applications against chronic and age-related diseases. One such phenolic acid that is being utilized in traditional medicine is chlorogenic acid (CGA). It is one of the most readily available phytochemicals that can be isolated from the leaves and fruits of plants such as coffee beans (CoffeaarabicaL.), apples (Malus spp.), artichoke (Cynara cardunculus L.), carrots (Daucus carota L.), betel (Piper be...
Source: Current Medicinal Chemistry - August 17, 2022 Category: Chemistry Authors: Amit Kumar Singh Rajeev K Singla Abhay K Pandey Source Type: research
Chlorogenic acid: A dietary phenolic acid with promising pharmacotherapeutic potential
Curr Med Chem. 2022 Aug 16. doi: 10.2174/0929867329666220816154634. Online ahead of print.ABSTRACTPhenolic acids are now receiving a great deal of interest as pervasive human dietary constituents that have various therapeutic applications against chronic and age-related diseases. One such phenolic acid that is being utilized in traditional medicine is chlorogenic acid (CGA). It is one of the most readily available phytochemicals that can be isolated from the leaves and fruits of plants such as coffee beans (CoffeaarabicaL.), apples (Malus spp.), artichoke (Cynara cardunculus L.), carrots (Daucus carota L.), betel (Piper be...
Source: Current Medicinal Chemistry - August 17, 2022 Category: Chemistry Authors: Amit Kumar Singh Rajeev K Singla Abhay K Pandey Source Type: research
Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice
AbstractArctigenin (Arc) is a phenylpropanoid dibenzylbutyrolactone lignan inArctium lappa L, which has been widely applied as a traditional Chinese herbal medicine for treating inflammation. In the present study, we explored the neuroprotective effect and the potential mechanisms of arctigenin against LPS-evoked neuroinflammation, neurodegeneration, and memory impairments in the mice hippocampus. Daily administration of arctigenin (50 mg/kg per day, i.g.) for 28 days revealed noticeable improvements in spatial learning and memory deficits after exposure to LPS treatment. Arctigenin prevented LPS-induced neuronal/synapt...
Source: Metabolic Brain Disease - July 28, 2022 Category: Neurology Source Type: research
Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression
Loss of extracellular matrix (ECM) of cartilage due to oxidative stress injury is one of the main characteristics of osteoarthritis (OA). As a bioactive molecule derived from the traditional Chinese Burdock, arct... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - June 27, 2022 Category: Nanotechnology Authors: Yang Liu, Mingzhuang Hou, Zejun Pan, Xin Tian, Zhijian Zhao, Tao Liu, Huilin Yang, Qin Shi, Xi Chen, Yijian Zhang, Fan He and Xuesong Zhu Tags: Research Source Type: research
Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves
Bioorg Chem. 2022 Jun 10;127:105940. doi: 10.1016/j.bioorg.2022.105940. Online ahead of print.ABSTRACTNine new cadinane-type sesquiterpenoids (1-9) and three new eucalyptane -type sesquiterpenes (10-12) were isolated from the ethyl acetate extract of Burdock leaves, which were commonly used for preventing or treating atherosclerosis in China. Their structures were confirmed by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis and ECD calculations. Compound 1 possessed the rare large conjugated skeleton. All the isolates were evaluated for anti-inflammatory and cholesterol-lowering activities by th...
Source: Bioorganic Chemistry - June 24, 2022 Category: Chemistry Authors: Hanjing Liang Qingmei Feng Hui Guo Jiangnan Lv Lingxia Zhang Qingxia Li Jun Chi Qiuyan Liu Zhimin Wang Liping Dai Source Type: research
Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves
Bioorg Chem. 2022 Jun 10;127:105940. doi: 10.1016/j.bioorg.2022.105940. Online ahead of print.ABSTRACTNine new cadinane-type sesquiterpenoids (1-9) and three new eucalyptane -type sesquiterpenes (10-12) were isolated from the ethyl acetate extract of Burdock leaves, which were commonly used for preventing or treating atherosclerosis in China. Their structures were confirmed by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis and ECD calculations. Compound 1 possessed the rare large conjugated skeleton. All the isolates were evaluated for anti-inflammatory and cholesterol-lowering activities by th...
Source: Atherosclerosis - June 24, 2022 Category: Cardiology Authors: Hanjing Liang Qingmei Feng Hui Guo Jiangnan Lv Lingxia Zhang Qingxia Li Jun Chi Qiuyan Liu Zhimin Wang Liping Dai Source Type: research
Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves
Bioorg Chem. 2022 Jun 10;127:105940. doi: 10.1016/j.bioorg.2022.105940. Online ahead of print.ABSTRACTNine new cadinane-type sesquiterpenoids (1-9) and three new eucalyptane -type sesquiterpenes (10-12) were isolated from the ethyl acetate extract of Burdock leaves, which were commonly used for preventing or treating atherosclerosis in China. Their structures were confirmed by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis and ECD calculations. Compound 1 possessed the rare large conjugated skeleton. All the isolates were evaluated for anti-inflammatory and cholesterol-lowering activities by th...
Source: Bioorganic Chemistry - June 24, 2022 Category: Chemistry Authors: Hanjing Liang Qingmei Feng Hui Guo Jiangnan Lv Lingxia Zhang Qingxia Li Jun Chi Qiuyan Liu Zhimin Wang Liping Dai Source Type: research
Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves
Bioorg Chem. 2022 Jun 10;127:105940. doi: 10.1016/j.bioorg.2022.105940. Online ahead of print.ABSTRACTNine new cadinane-type sesquiterpenoids (1-9) and three new eucalyptane -type sesquiterpenes (10-12) were isolated from the ethyl acetate extract of Burdock leaves, which were commonly used for preventing or treating atherosclerosis in China. Their structures were confirmed by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis and ECD calculations. Compound 1 possessed the rare large conjugated skeleton. All the isolates were evaluated for anti-inflammatory and cholesterol-lowering activities by th...
Source: Atherosclerosis - June 24, 2022 Category: Cardiology Authors: Hanjing Liang Qingmei Feng Hui Guo Jiangnan Lv Lingxia Zhang Qingxia Li Jun Chi Qiuyan Liu Zhimin Wang Liping Dai Source Type: research
