Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis
Biochem Biophys Res Commun. 2024 Apr 4;710:149895. doi: 10.1016/j.bbrc.2024.149895. Online ahead of print.ABSTRACTNeurotoxicity is a common side effect of certain types of therapeutic drugs, posing a major hurdle for their clinical application. Accumulating evidence suggests that ferroptosis is involved in the neurotoxicity induced by these drugs. Therefore, targeting ferroptosis is considered to be a reasonable approach to prevent such side effect. Arctigenin (ATG) is a major bioactive ingredient of Arctium lappa L., a popular medicinal plant in Asia, and has been reported to have multiple bioactivities including neuropro...
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Zhuoqun Li Lixing Cao Kai Han Lihong Fan Chong Zhao Shutao Yin Hongbo Hu Source Type: research
Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis
Biochem Biophys Res Commun. 2024 Apr 4;710:149895. doi: 10.1016/j.bbrc.2024.149895. Online ahead of print.ABSTRACTNeurotoxicity is a common side effect of certain types of therapeutic drugs, posing a major hurdle for their clinical application. Accumulating evidence suggests that ferroptosis is involved in the neurotoxicity induced by these drugs. Therefore, targeting ferroptosis is considered to be a reasonable approach to prevent such side effect. Arctigenin (ATG) is a major bioactive ingredient of Arctium lappa L., a popular medicinal plant in Asia, and has been reported to have multiple bioactivities including neuropro...
Source: Biochemical and Biophysical Research communications - April 9, 2024 Category: Biochemistry Authors: Zhuoqun Li Lixing Cao Kai Han Lihong Fan Chong Zhao Shutao Yin Hongbo Hu Source Type: research
Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis
Biochem Biophys Res Commun. 2024 Apr 4;710:149895. doi: 10.1016/j.bbrc.2024.149895. Online ahead of print.ABSTRACTNeurotoxicity is a common side effect of certain types of therapeutic drugs, posing a major hurdle for their clinical application. Accumulating evidence suggests that ferroptosis is involved in the neurotoxicity induced by these drugs. Therefore, targeting ferroptosis is considered to be a reasonable approach to prevent such side effect. Arctigenin (ATG) is a major bioactive ingredient of Arctium lappa L., a popular medicinal plant in Asia, and has been reported to have multiple bioactivities including neuropro...
Source: Biochemical and Biophysical Research communications - April 9, 2024 Category: Biochemistry Authors: Zhuoqun Li Lixing Cao Kai Han Lihong Fan Chong Zhao Shutao Yin Hongbo Hu Source Type: research
The protective effects of Arctiin in asthma by attenuating airway inflammation and inhibiting p38/NF- κB signaling
In this study, an asthma model was established in mice by stimulation with ovalbumin (OVA). Bronchoalveolar lavage (BALF) was collected from OVA-challenged mice and the cells were counted. Lung tissue was harvested for hematoxylin-eosin (HE) staining and measurement of Wet/Dry weight ratios. The expressions of proteins were detected using enzyme-linked immunosorbent assay (ELISA) and Western blots. The superoxide dismutase (SOD) activity in lung tissue was measured using a commercial kit. We found that Arctiin had beneficial effects on asthma treatment. Firstly, it attenuated OVA-challenged lung pathological alterations. S...
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Lang Yuan Chao Sun Source Type: research
The protective effects of Arctiin in asthma by attenuating airway inflammation and inhibiting p38/NF- κB signaling
In this study, an asthma model was established in mice by stimulation with ovalbumin (OVA). Bronchoalveolar lavage (BALF) was collected from OVA-challenged mice and the cells were counted. Lung tissue was harvested for hematoxylin-eosin (HE) staining and measurement of Wet/Dry weight ratios. The expressions of proteins were detected using enzyme-linked immunosorbent assay (ELISA) and Western blots. The superoxide dismutase (SOD) activity in lung tissue was measured using a commercial kit. We found that Arctiin had beneficial effects on asthma treatment. Firstly, it attenuated OVA-challenged lung pathological alterations. S...
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Lang Yuan Chao Sun Source Type: research
Review of the standards of proof (of safety) for FDA regulated consumer products and how the generally recognized as safe criteria could be applied to cosmetics
Regul Toxicol Pharmacol. 2024 Mar 15:105603. doi: 10.1016/j.yrtph.2024.105603. Online ahead of print.ABSTRACTThe Modernization of Cosmetics Regulation Act of 2022 (MoCRA) amends the Food, Drug and Cosmetic Act (FDCA), elevating the standard of proof of safety (better known as a "safety standard") for cosmetics to the standard of a "reasonable certainty … [of] … safe."a standard equal to that of food ingredients. The standards of the proof of safety differ for various classes of FDA-regulated product categories (e.g., cosmetics, dietary supplements, food ingredients and food itself). This manuscript describes the variou...
Source: Regulatory Toxicology and Pharmacology : RTP - March 17, 2024 Category: Toxicology Authors: George A Burdock Source Type: research
Review of the standards of proof (of safety) for FDA regulated consumer products and how the generally recognized as safe criteria could be applied to cosmetics
Regul Toxicol Pharmacol. 2024 Mar 15:105603. doi: 10.1016/j.yrtph.2024.105603. Online ahead of print.ABSTRACTThe Modernization of Cosmetics Regulation Act of 2022 (MoCRA) amends the Food, Drug and Cosmetic Act (FDCA), elevating the standard of proof of safety (better known as a "safety standard") for cosmetics to the standard of a "reasonable certainty … [of] … safe."a standard equal to that of food ingredients. The standards of the proof of safety differ for various classes of FDA-regulated product categories (e.g., cosmetics, dietary supplements, food ingredients and food itself). This manuscript describes the variou...
Source: Regulatory Toxicology and Pharmacology : RTP - March 17, 2024 Category: Toxicology Authors: George A Burdock Source Type: research
Molecules, Vol. 29, Pages 937: A Network of Processes for Biorefining Burdock Seeds and Roots
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Carlo Pastore
In this work, a novel sustainable approach was proposed for the integral valorisation of Arctium lappa (burdock) seeds and roots. Firstly, a preliminary recovery of bioactive compounds, including unsaturated fatty acids, was performed. Then, simple sugars (i.e., fructose and sucrose) and phenolic compounds were extracted by using compressed fluids (supercritical CO2 and propane). Consequently, a complete characterisation of raw biomass and extraction residues was carried out to determine the starting chemical composition in terms of residual lipids, proteins, hemicellulose, cellulose, lignin, and ash...
Source: Molecules - February 21, 2024 Category: Chemistry Authors: Luigi di Bitonto Enrico Scelsi Massimiliano Errico Hilda Elizabeth Reynel- Ávila Didilia Ileana Mendoza-Castillo Adri án Bonilla-Petriciolet Marcos Lucio Corazza Luis Ricardo Shigueyuki Kanda Martin H ájek Roumiana P. Stateva Carlo Pastore Tags: Article Source Type: research
Effects of extraction methods on the physicochemical properties and functionalities of pectic polysaccharides from burdock (Arctium lappa L.)
Int J Biol Macromol. 2023 Dec 10:128684. doi: 10.1016/j.ijbiomac.2023.128684. Online ahead of print.ABSTRACTIn this work, the effects of four different extraction methods, acid (HCl), alkali (NaOH), enzymes (cellulase/pectinase), and buffer (pH 7.0) on the physicochemical properties and functionalities of burdock pectin were systematically investigated and compared. Buffer extraction gave a low yield (2.8 %) and is therefore limited in its application. The acid treatment hydrolyzed the neutral sidechains and gave a homogalacturonan content of 72.6 %. By contrast, alkali and enzymes preserved the sidechains while degrading ...
Source: International Journal of Biological Macromolecules - December 12, 2023 Category: Biochemistry Authors: Zhen Wang Wancheng Song Haizhao Song Wuyang Huang Ying Li Jin Feng Source Type: research
Effects of extraction methods on the physicochemical properties and functionalities of pectic polysaccharides from burdock (Arctium lappa L.)
Int J Biol Macromol. 2023 Dec 10:128684. doi: 10.1016/j.ijbiomac.2023.128684. Online ahead of print.ABSTRACTIn this work, the effects of four different extraction methods, acid (HCl), alkali (NaOH), enzymes (cellulase/pectinase), and buffer (pH 7.0) on the physicochemical properties and functionalities of burdock pectin were systematically investigated and compared. Buffer extraction gave a low yield (2.8 %) and is therefore limited in its application. The acid treatment hydrolyzed the neutral sidechains and gave a homogalacturonan content of 72.6 %. By contrast, alkali and enzymes preserved the sidechains while degrading ...
Source: International Journal of Biological Macromolecules - December 12, 2023 Category: Biochemistry Authors: Zhen Wang Wancheng Song Haizhao Song Wuyang Huang Ying Li Jin Feng Source Type: research
Acute and chronic toxicity in Sprague-Dawley rats of orally-administered total lignans from Arctii Fructus, a potential therapeutic drug for diabetes
This study evaluated the acute and chronic (26 weeks) toxicities associated with oral daily administration of TLAF in Sprague-Dawley (SD) rats. An acute-toxicity test showed that TLAF caused 10% mortality at 3,000 mg/kg × 2 (6-h interval), with toxic symptoms, such as dyspnea and tonic convulsions, indicating potential neurotoxicity. A chronic-toxicity study showed no mortality after administration. The no observed adverse-effect level was 1,800 mg/kg (approximately 54 times higher than the human clinical dose) for 26 weeks of TLAF oral administration in SD rats, with toxicity signs of excessive oral and nasal secretions ...
Source: Regulatory Toxicology and Pharmacology : RTP - December 9, 2023 Category: Toxicology Authors: Jinwang Mei Xiaobo Li Zhiyong Xu Haiyang Zhao Jingyun Zhang Qin Xu Zhaohui Xu Source Type: research
Long ‐term oral administration of burdock fructooligosaccharide alleviates DSS‐induced colitis in mice by mediating anti‐inflammatory effects and protection of intestinal barrier function
ConclusionBFO effectively alleviated the symptoms of DSS-induced colitis by mediating anti-inflammatory effects and protecting the intestinal barrier integrity, thereby potentially facilitating the utilization of safer and more efficacious polysaccharides for managing chronic inflammatory diseases. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 22, 2023 Category: Allergy & Immunology Authors: Qunfei Ma,
Xiujuan Zhang,
Xuan Xu,
Yan Lu,
Qiang Chen,
Yiru Chen,
Chunyan Liu,
Kaoshan Chen Tags: ORIGINAL ARTICLE Source Type: research
Immune regulation and inflammation inhibition of Arctium lappa L. polysaccharides by TLR4/NF- κB signaling pathway in cells
Int J Biol Macromol. 2023 Oct 31:127700. doi: 10.1016/j.ijbiomac.2023.127700. Online ahead of print.ABSTRACTArctium lappa L. polysaccharides (ALP) are important active ingredients of burdocks with various bioactivities. In the present study, a crude polysaccharide was extracted from A. lappa L. roots and purified using DEAE-52 and Sephacryl™ S-400 columns to reach 99 % purity. This neutral polysaccharide contained fructose, glucose, galactose and arabinose in a ratio of 0.675:0.265:0.023:0.016 and had a Mw of 4256 Da. The immunomodulatory activity and intestinal inflammation inhibitory effects of ALP were investigated in...
Source: International Journal of Biological Macromolecules - November 2, 2023 Category: Biochemistry Authors: Feng Zeng Ying Li Xiaoxiao Zhang Li Shen Xingyu Zhao Trust Beta Bin Li Rui Chen Wuyang Huang Source Type: research
Molecules, Vol. 28, Pages 7257: Chlorogenic Acid from Burdock Roots Ameliorates Oleic Acid-Induced Steatosis in HepG2 Cells through AMPK/ACC/CPT-1 Pathway
In this study, we found that ACQA reduced the number of lipid droplets and lipid levels in oleic acid-treated HepG2 cells. Molecular mechanistic results showed that ACQA enhanced CPT-1 expression by activating AMPK-related signaling pathways, and the concentrations of Ca2+ and cAMP were increased with the intervention of ACQA. In addition, ACQA enhanced the β-oxidation of fatty acids, reduced alanine transaminase and aspartate transaminase, and inhibited apoptosis in oleic acid-treated HepG2 cells. Our studies elucidate a novel mechanism that ACQA enhances the β-oxidation of fatty acids through th...
Source: Molecules - October 25, 2023 Category: Chemistry Authors: Kaiyang Ma Weixi Sheng Xinxin Song Jiangfeng Song Ying Li Wuyang Huang Yuanfa Liu Tags: Article Source Type: research
< em > Arctium lappa L. < /em > root polysaccharides ameliorate CCl < sub > 4 < /sub > -induced acute liver injury by suppressing oxidative stress, inflammation and apoptosis
In conclusion, ALP possesses a hepatoprotective effect mediated by attenuating oxidative damage, inflammation and apoptosis in ALI.PMID:37867310 | DOI:10.1080/14786419.2023.2272287 (Source: Natural Product Research)
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Wen Xiang Jiayi Wei Lifei Lv Xinghui Yu Yan Xie Li Zhang Naiyan Lu Wentao Jiang Source Type: research
