Preclinical Evidence that Arctigenin Effectively and Selectively Targets Clear Cell Renal Cell Carcinoma Via Suppressing EGFR and RhoA
Nutr Cancer. 2023 Mar 22:1-9. doi: 10.1080/01635581.2023.2178920. Online ahead of print.ABSTRACTClear cell renal cell carcinoma (ccRCC) has poor clinical outcomes and necessitates new treatment options. Epidermal growth factor receptor (EGFR) is a potential therapeutic target, due to the associations with various carcinomas' progression. Arctigenin, a natural compound of Arctium lappa, has been shown to display anticancer abilities in various carcinomas. Cellular assays and combination studies were conducted using arctigenin and anti-ccRCC drugs. In vivo efficacy of arctigenin was determined using ccRCC xenograft mouse mod...
Source: Nutrition and Cancer - March 22, 2023 Category: Cancer & Oncology Authors: Dongcao Liu Guang Zhou Mingwei Xu Source Type: research
Preclinical Evidence that Arctigenin Effectively and Selectively Targets Clear Cell Renal Cell Carcinoma Via Suppressing EGFR and RhoA
Nutr Cancer. 2023 Mar 22:1-9. doi: 10.1080/01635581.2023.2178920. Online ahead of print.ABSTRACTClear cell renal cell carcinoma (ccRCC) has poor clinical outcomes and necessitates new treatment options. Epidermal growth factor receptor (EGFR) is a potential therapeutic target, due to the associations with various carcinomas' progression. Arctigenin, a natural compound of Arctium lappa, has been shown to display anticancer abilities in various carcinomas. Cellular assays and combination studies were conducted using arctigenin and anti-ccRCC drugs. In vivo efficacy of arctigenin was determined using ccRCC xenograft mouse mod...
Source: Nutrition and Cancer - March 22, 2023 Category: Cancer & Oncology Authors: Dongcao Liu Guang Zhou Mingwei Xu Source Type: research
Experimental evaluation of a hybrid solar dryer with flexible open sorption thermal energy storage unit on demand for burdock root drying
Environ Sci Pollut Res Int. 2023 Mar 18. doi: 10.1007/s11356-023-26160-9. Online ahead of print.ABSTRACTSolar drying represents an attractive way to implement an efficient and green development strategy. The viability of open sorption thermal energy storage (OSTES) can compensate for the inherent shortcomings of intermittency and instability of solar energy for ensuring the continuity of the drying process. Nevertheless, the existing solar-powered OSTES technologies only allow a batch mode while being severely restricted by sunlight's availability, thereby heavily limiting the flexibility in managing OSTES on demand. Herei...
Source: Environmental Science and Pollution Research International - March 18, 2023 Category: Environmental Health Authors: Rong Zhu Qiongfen Yu Ming Li Yiping Xia Aimin Li Danya Zhan Yinning Li Yunfeng Wang Source Type: research
Chemoproteomics reveals arctigenin as a phagophore-closure blocker via targeting ESCRT-I subunit VPS28
In this study, we designed and synthesized photo-crosslinkable arctigenin probes and utilized them in the chemoproteomic profiling of potential target proteins directly in living cells. Vacuolar protein sorting-associated protein 28 (VPS28), a key subunit of the ESCRT-I complex implicated in phagophore closure, was successfully identified. Unexpectedly, we found that arctigenin degraded VPS28 via the ubiquitin-proteasome pathway. We also demonstrated that arctigenin induces a prominent phagophore closure-blockade phenotype in PANC-1 cells. To the best of our knowledge, this is the first report of a small molecule acting as...
Source: Bioorganic Chemistry - March 12, 2023 Category: Chemistry Authors: Jinyan Han Yifang Yu Shasha Li Ruoyang Miao Weiyan Cheng Han Wei Source Type: research
Chemoproteomics reveals arctigenin as a phagophore-closure blocker via targeting ESCRT-I subunit VPS28
In this study, we designed and synthesized photo-crosslinkable arctigenin probes and utilized them in the chemoproteomic profiling of potential target proteins directly in living cells. Vacuolar protein sorting-associated protein 28 (VPS28), a key subunit of the ESCRT-I complex implicated in phagophore closure, was successfully identified. Unexpectedly, we found that arctigenin degraded VPS28 via the ubiquitin-proteasome pathway. We also demonstrated that arctigenin induces a prominent phagophore closure-blockade phenotype in PANC-1 cells. To the best of our knowledge, this is the first report of a small molecule acting as...
Source: Bioorganic Chemistry - March 12, 2023 Category: Chemistry Authors: Jinyan Han Yifang Yu Shasha Li Ruoyang Miao Weiyan Cheng Han Wei Source Type: research
Genomic characterization of a novel torradovirus infecting Arctium lappa L. in China
AbstractBurdock (Arctium lappa L.) is not only a popular vegetable crop but also an important medicinal plant. In burdock plants with symptoms of leaf mosaic, a novel torradovirus tentatively named"burdock mosaic virus" (BdMV) was identified by high-throughput sequencing. The complete genomic sequence of BdMV was further determined using RT-PCR and the rapid amplification of cDNA ends (RACE) method. The genome is composed of two positive-sense single-stranded RNAs. RNA1 (6991 nt) encodes a polyprotein of 2186 aa, and RNA2 (4700 nt) encodes a protein of 201 aa and a polyprotein of 1212 aa that is predicted to be p...
Source: Archives of Virology - March 11, 2023 Category: Virology Source Type: research
Arctigenin Prevents Retinal Edema in a Murine Retinal Vein Occlusion Model
In this study, the degree of retinal edema by measuring the total retinal thickness using optical coherence tomography (OCT) and the thickness of the inner nuclear layer (INL) by hematoxylin-eosin (H&E) staining were investigated. Oral administration of arctigenin ameliorated retinal edema in an RVO murine model by inhibiting the decrease in occludin and vascular endothelial (VE)-cadherin. Moreover, in retinas with edema, arctigenin suppressed the induction of VEGF, tumor necrosis factor α (TNFα), and matrix metallopeptidase 9 (MMP9). Next, the effects of arctigenin on barrier function were assessed in human retinal ...
Source: Biological and Pharmaceutical Bulletin - March 1, 2023 Category: Drugs & Pharmacology Authors: Yae Hidaka Shinsuke Nakamura Anri Nishinaka Yuichi Takajo Satoshi Inamasu Satoshi Yomoda Masamitsu Shimazawa Hideaki Hara Source Type: research
Arctigenin Prevents Retinal Edema in a Murine Retinal Vein Occlusion Model
In this study, the degree of retinal edema by measuring the total retinal thickness using optical coherence tomography (OCT) and the thickness of the inner nuclear layer (INL) by hematoxylin-eosin (H&E) staining were investigated. Oral administration of arctigenin ameliorated retinal edema in an RVO murine model by inhibiting the decrease in occludin and vascular endothelial (VE)-cadherin. Moreover, in retinas with edema, arctigenin suppressed the induction of VEGF, tumor necrosis factor α (TNFα), and matrix metallopeptidase 9 (MMP9). Next, the effects of arctigenin on barrier function were assessed in human retinal ...
Source: Biological and Pharmaceutical Bulletin - March 1, 2023 Category: Drugs & Pharmacology Authors: Yae Hidaka Shinsuke Nakamura Anri Nishinaka Yuichi Takajo Satoshi Inamasu Satoshi Yomoda Masamitsu Shimazawa Hideaki Hara Source Type: research
Arctigenin Prevents Retinal Edema in a Murine Retinal Vein Occlusion Model
In this study, the degree of retinal edema by measuring the total retinal thickness using optical coherence tomography (OCT) and the thickness of the inner nuclear layer (INL) by hematoxylin-eosin (H&E) staining were investigated. Oral administration of arctigenin ameliorated retinal edema in an RVO murine model by inhibiting the decrease in occludin and vascular endothelial (VE)-cadherin. Moreover, in retinas with edema, arctigenin suppressed the induction of VEGF, tumor necrosis factor α (TNFα), and matrix metallopeptidase 9 (MMP9). Next, the effects of arctigenin on barrier function were assessed in human retinal ...
Source: Biological and Pharmaceutical Bulletin - March 1, 2023 Category: Drugs & Pharmacology Authors: Yae Hidaka Shinsuke Nakamura Anri Nishinaka Yuichi Takajo Satoshi Inamasu Satoshi Yomoda Masamitsu Shimazawa Hideaki Hara Source Type: research
Arctigenin Prevents Retinal Edema in a Murine Retinal Vein Occlusion Model
In this study, the degree of retinal edema by measuring the total retinal thickness using optical coherence tomography (OCT) and the thickness of the inner nuclear layer (INL) by hematoxylin-eosin (H&E) staining were investigated. Oral administration of arctigenin ameliorated retinal edema in an RVO murine model by inhibiting the decrease in occludin and vascular endothelial (VE)-cadherin. Moreover, in retinas with edema, arctigenin suppressed the induction of VEGF, tumor necrosis factor α (TNFα), and matrix metallopeptidase 9 (MMP9). Next, the effects of arctigenin on barrier function were assessed in human retinal ...
Source: Biological and Pharmaceutical Bulletin - March 1, 2023 Category: Drugs & Pharmacology Authors: Yae Hidaka Shinsuke Nakamura Anri Nishinaka Yuichi Takajo Satoshi Inamasu Satoshi Yomoda Masamitsu Shimazawa Hideaki Hara Source Type: research
Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin – An ex vivo Study on Rat Brain Slices
Planta Med DOI: 10.1055/a-2005-5497Arctigenin is a bioactive dibenzylbutyrolactone-type lignan exhibiting various pharmacological activities. The neuroprotective effects of arctigenin were demonstrated to be mediated via
inhibition of AMPA and KA type glutamate receptors in the somatosensory cortex of the rat brain. The aim of this study was to compare the effects of arctigenin with matairesinol and
trachelogenin on synaptic activity in ex vivo rat brain slices. Arctigenin, matairesinol and trachelogenin were isolated from Arctium lappa, Centaurea scabiosa and Cirsium
arvense, respectively, and applied on br...
Source: Planta Medica - February 16, 2023 Category: Drugs & Pharmacology Authors: Koech, Peter Kiplang ʼat J ócsák, Gergely Boldizs ár, Imre Moldov án, Kinga Borb ély, Sándor Vil ági, Ildikó Dobolyi, Arp ád Varr ó, Petra Tags: Original Papers Source Type: research
The burdock database: a multi-omic database for Arctium lappa, a food and medicinal plant
Burdock is a biennial herb of Asteraceae found in Northern Europe, Eurasia, Siberia, and China. Its mature dry fruits, called Niu Bang Zi, are recorded in various traditional Chinese medicine books. With the deve... (Source: BMC Plant Biology)
Source: BMC Plant Biology - February 9, 2023 Category: Biology Authors: Yueyue Song, Yanyun Yang, Liang Xu, Che Bian, Yanping Xing, Hefei Xue, Wenjuan Hou, Wenxiao Men, Deqiang Dou and Tingguo Kang Tags: Research Source Type: research
Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells
CONCLUSION: LAF exerts antitumor effects via S phase arrest by activating CDKN1C/p57 in colorectal cancer cells.PMID:36708218 | DOI:10.1080/13880209.2023.2172048 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - January 28, 2023 Category: Drugs & Pharmacology Authors: Rui-Yi Yang Jia-Yi Tan Zhe Liu Xiao-Ling Shen Ying-Jie Hu Source Type: research
Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells
CONCLUSION: LAF exerts antitumor effects via S phase arrest by activating CDKN1C/p57 in colorectal cancer cells.PMID:36708218 | PMC:PMC9888477 | DOI:10.1080/13880209.2023.2172048 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - January 28, 2023 Category: Drugs & Pharmacology Authors: Rui-Yi Yang Jia-Yi Tan Zhe Liu Xiao-Ling Shen Ying-Jie Hu Source Type: research
