Molecular epidemiology and antimicrobial resistance of Haemophilus influenzae isolates from otitis media in Bulgaria
Acta Microbiol Immunol Hung. 2023 Nov 8. doi: 10.1556/030.2023.02126. Online ahead of print.ABSTRACTHaemophilus influenzae is one of the main bacteria responsible for otitis media (OM) among children worldwide. We aimed to estimate the distribution of encapsulated and non-capsulated variants (NTHi), biotypes, antibiotic susceptibility, and molecular epidemiology of H. influenzae isolates recovered from pediatric OM cases in Bulgaria.Capsule detection was done by PCR for bexB gene, absent in NTHi. All encapsulated strains were subjected to PCR serotyping. MIC susceptibility testing was performed according to the criteria of...
Source: Acta Microbiologica et Immunologica Hungarica - November 8, 2023 Category: Microbiology Authors: Alexandra Sashova Alexandrova Ivo Nikolaev Sirakov Lena Petrova Setchanova Kalina Ionkova Mihova Daniela Rosenova Pencheva Raina Tsvetanova Gergova Source Type: research
Molecular epidemiology and antimicrobial resistance of Haemophilus influenzae isolates from otitis media in Bulgaria
Acta Microbiol Immunol Hung. 2023 Nov 8. doi: 10.1556/030.2023.02126. Online ahead of print.ABSTRACTHaemophilus influenzae is one of the main bacteria responsible for otitis media (OM) among children worldwide. We aimed to estimate the distribution of encapsulated and non-capsulated variants (NTHi), biotypes, antibiotic susceptibility, and molecular epidemiology of H. influenzae isolates recovered from pediatric OM cases in Bulgaria.Capsule detection was done by PCR for bexB gene, absent in NTHi. All encapsulated strains were subjected to PCR serotyping. MIC susceptibility testing was performed according to the criteria of...
Source: Acta Microbiologica et Immunologica Hungarica - November 8, 2023 Category: Microbiology Authors: Alexandra Sashova Alexandrova Ivo Nikolaev Sirakov Lena Petrova Setchanova Kalina Ionkova Mihova Daniela Rosenova Pencheva Raina Tsvetanova Gergova Source Type: research
The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study
DiscussionOur results point to the possible role of theinterventions related to the adequate control of epilepsy along with improvement of the mental health status to be important in order to reduce MS burden in the PwMS with comorbid seizure/epilepsy. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - November 7, 2023 Category: Allergy & Immunology Source Type: research
Genes, Vol. 14, Pages 2023: Navigating the ALS Genetic Labyrinth: The Role of MAPT Haplotypes
Albena Todorova
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by wide clinical and biological heterogeneity, with a large proportion of ALS patients also exhibiting frontotemporal dementia (FTD) spectrum symptoms. This project aimed to characterize risk subtypes of the H1 haplotype within the MAPT (microtubule-associated protein tau) gene, according to their possible effect as a risk factor and as a modifying factor in relation to the age of disease onset. One hundred patients from Bulgaria with sporadic ALS were genotyped for the variants rs1467967, rs242557, rs1800547, rs3785883, ...
Source: Genes - October 30, 2023 Category: Genetics & Stem Cells Authors: Ivan Tourtourikov Kristiyan Dabchev Tihomir Todorov Teodor Angelov Teodora Chamova Ivailo Tournev Tanya Kadiyska Vanyo Mitev Albena Todorova Tags: Article Source Type: research
A multicenter icet-a study on age at menarche and menstrual cycles in patients with transfusion-dependent thalassemia (tdt) who started early chelation therapy with different chelating agents.
Conclusions: Early chelation does not necessary correlate with efficient chelation during pubertal age. Delayed menarche, related to high SF levels, was still frequent in most Centers and was a forerunner of irregular menstrual cycles, SA and associated complications. Neglecting the importance of adherence to iron chelation therapy (ICT), despite innovative and expensive therapies, may lead to complications and decreased quality of life. Key words: Transfusion-dependent thalassemia, menarche, menstrual cycles, iron chelation therapy (ICT), iron overload, adherence to treatment. (Source: Mediterranean Journal of ...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 30, 2023 Category: Hematology Authors: SALVATORE DI MAIO, VINCENZO DE SANCTIS, PIERLUIGI MARZUILLO, CHRISTOS KATTAMIS, SHAHINA DAAR, MEHERAN KARIMI, SAKI FOROUGH, ATANAS BANKEV, VALERIA KALEVA, SOTEROULA CHRISTOU, CARMELO FORTUGNO, POLYXENI DELAPORTA, ASHRAF T SOLIMAN , PLOUTARCHOS TZOULIS Source Type: research
Attitudes of Bulgarian Patients with Epilepsy to COVID-19 Vaccination
(Source: American Journal of Health Behavior)
Source: American Journal of Health Behavior - October 28, 2023 Category: Psychiatry & Psychology Authors: Viteva, Ekaterina Source Type: research
Preserved ratio impaired spirometry (PRISm) as a spirometric pattern among Bulgarian asthma patients
Conclusion: The restrictive pattern in patients with obstructive diseases is a possible finding and may be due to obesity or pulmonary hyperinflation. Bronchodilator test increases the reliability of the examination. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Koleva Mandadzhieva, S., Stoimenova, P. Tags: Monitoring airway disease Source Type: research
Cystic fibrosis fransmembrane regulator modulator therapies effect on liver function in Bulgarian patients
Conclusion: We did not identify worsening in the liver status after CFTRm therapy with CTFRm. The results of the study suggest an improvement of liver function after initiation of IVA/LUM. As a limitation of our study there are not patients with very advanced liver cirrhosis included on CFTRm therapy. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Petkova, D., Baycheva, M., Petkova, V., Papochieva, V., Genkova, K., Andonova, Y., Nikolov, I., Shahid, P., Miteva, D., Petrova, G. Tags: Paediatric cystic fibrosis (CF) Source Type: research
Hand surgery in Bulgaria
J Hand Surg Eur Vol. 2023 Oct 25:17531934231205545. doi: 10.1177/17531934231205545. Online ahead of print.NO ABSTRACTPMID:37879638 | DOI:10.1177/17531934231205545 (Source: Hand Surgery)
Source: Hand Surgery - October 25, 2023 Category: Surgery Authors: Kalin O Dimitrov Source Type: research
Application of OMOP Common Data Model for Data Integration: The Bulgarian Diabetes Register
Stud Health Technol Inform. 2023 Oct 20;309:141-142. doi: 10.3233/SHTI230761.ABSTRACTThis paper considers mapping of the Bulgarian Diabetes Register(BDR) onto OMOP Common Data Model (CDM). Research results are referenced and plans for analysis of drug shortages from federated data sources are outlined.PMID:37869827 | DOI:10.3233/SHTI230761 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - October 23, 2023 Category: Information Technology Authors: Evgeniy Krastev Dimitar Tcharaktchiev Simeon Abanos Source Type: research
