Molecules, Vol. 29, Pages 1474: In Silico and Chromatographic Methods for Analysis of Biotransformation of Prospective Neuroprotective Pyrrole-Based Hydrazone in Isolated Rat Hepatocytes
exander Zlatkov
In the current study, chromatographic and in silico techniques were applied to investigate the biotransformation of ethyl 5-(4-bromophenyl)-1-(2-(2-(2-hydroxybenzylidene) hydrazinyl)-2-oxoethyl)-2-methyl-1H-pyrrole-3-carboxylate (11b) in hepatocytic media. The initial chromatographic procedure was based on the employment of the conventional octadecyl stationary phase method for estimation of the chemical stability. Subsequently, a novel and rapid chromatographic approach based on a phenyl–hexyl column was developed, aiming to separate the possible metabolites. Both methods were performed o...
Source: Molecules - March 26, 2024 Category: Chemistry Authors: Alexandrina Mateeva Magdalena Kondeva-Burdina Emilio Mateev Paraskev Nedialkov Karolina Lyubomirova Lily Peikova Maya Georgieva Alexander Zlatkov Tags: Article Source Type: research
Heart failure care in the Central and Eastern Europe and Baltic region: status, barriers, and routes to improvement
AbstractDespite improvements over recent years, morbidity and mortality associated with heart failure (HF) are higher in countries in the Central and Eastern Europe and Baltic region than in Western Europe. With the goal of improving the standard of HF care and patient outcomes in the Central and Eastern Europe and Baltic region, this review aimed to identify the main barriers to optimal HF care and potential areas for improvement. This information was used to suggest methods to improve HF management and decrease the burden of HF in the region that can be implemented at the national and regional levels. We performed a lite...
Source: ESC Heart Failure - March 23, 2024 Category: Cardiology Authors: Ovidiu Chioncel,
Jelena Čelutkienė,
Jan Bělohlávek,
Ginta Kamzola,
Mitja Lainscak,
Béla Merkely,
Davor Miličić,
Jadwiga Nessler,
Arsen D. Ristić,
Lidia Sawiełajc,
Izabella Uchmanowicz,
Tiina Uuetoa,
Eva Turgonyi,
Yoto Yotov,
Piotr P Tags: Review Source Type: research
Moving forward after the COVID-19 pandemic: Lessons learned in primary care from the multi-country PRICOV-19 study
CONCLUSION: Policymakers, primary care associations, and the broader healthcare system are urged to collaboratively take responsibility and increase support for GP practices to enhance their resilience, adaptability, and capacity to deliver safe and equitable healthcare during future crises.PMID:38511848 | DOI:10.1080/13814788.2024.2328716 (Source: European Journal of General Practice)
Source: European Journal of General Practice - March 21, 2024 Category: Primary Care Authors: Sara Willems Pierre Vanden Bussche Esther Van Poel Claire Collins Zalika Klemenc-Ketis Source Type: research
Women in spine surgery: can we change the society?
ConclusionWomen in surgery, mainly in neurosurgery, are being treated by society in an unequal way. Female surgeons are still discriminated because of their gender. The most patients prefer female physicians to talk to, but still believe that they are incapable to perform spine surgery. We cannot stop this until we change our mindset and perception of reality. (Source: European Spine Journal)
Source: European Spine Journal - March 20, 2024 Category: Orthopaedics Source Type: research
