Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: American Journal of Physiology. Renal Physiology - March 14, 2024 Category: Physiology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: American Journal of Physiology. Renal Physiology - March 14, 2024 Category: Physiology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: Am J Physiol Renal P... - March 14, 2024 Category: Urology & Nephrology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: Am J Physiol Renal P... - March 14, 2024 Category: Urology & Nephrology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: American Journal of Physiology. Renal Physiology - March 14, 2024 Category: Physiology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: Am J Physiol Renal P... - March 14, 2024 Category: Urology & Nephrology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: American Journal of Physiology. Renal Physiology - March 14, 2024 Category: Physiology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: Am J Physiol Renal P... - March 14, 2024 Category: Urology & Nephrology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: American Journal of Physiology. Renal Physiology - March 14, 2024 Category: Physiology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: Am J Physiol Renal P... - March 14, 2024 Category: Urology & Nephrology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: American Journal of Physiology. Renal Physiology - March 14, 2024 Category: Physiology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
Quantitative phenotyping of < em > Nphs1 < /em > knockout mice as a prerequisite for gene replacement studies
Am J Physiol Renal Physiol. 2024 Mar 14. doi: 10.1152/ajprenal.00412.2023. Online ahead of print.ABSTRACTSteroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podoc...
Source: Am J Physiol Renal P... - March 14, 2024 Category: Urology & Nephrology Authors: Florian Buerger Lea M Merz Ken Saida Seyoung Yu Daanya Salmanullah Katharina Lemberg Nils D Mertens Bshara Mansour Caroline M Kolvenbach Kirollos Yousef Alina Braun Gijs A C Franken Nicole Endlich Ronen Schneider Shrilee Shril Friedhelm Hildebrandt Source Type: research
GSE256269 Differential transcriptomic responses to heat in wild-type and heat-evolved Symbiodiniaceae in corals
Contributors : Hugo Scharfenstein ; Patrick Buerger ; Matthew Nitschke ; Lesa Peplow ; Wing Y Chan ; Madeleine van OppenSeries Type : Expression profiling by high throughput sequencingOrganism : Platygyra daedaleaHeat-evolved Symbiodiniaceae can improve the physiological performances of their coral host under heat stress, but their gene expression responses to heat remained unknown. We explore here the transcriptomic basis of differential thermal stress responses between in hospite wild-type and heat-evolved Cladocopium proliferum strains and their coral host Platygyra daedealea. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Platygyra daedalea Source Type: research
Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia
Neurobiol Aging. 2024 Feb 2;136:99-110. doi: 10.1016/j.neurobiolaging.2024.01.012. Online ahead of print.ABSTRACTHere, we investigated whether fractional anisotropy (FA) of hippocampus-relevant white-matter tracts mediates the association between baseline Mediterranean diet adherence (MeDiAd) and verbal episodic memory over four years. Participants were healthy older adults with and without subjective cognitive decline and patients with amnestic mild cognitive impairment from the DELCODE cohort study (n = 376; age: 71.47 ± 6.09 years; 48.7 % female). MeDiAd and diffusion data were obtained at baseline. Verbal episodic mem...
Source: Neurobiology of Aging - February 10, 2024 Category: Geriatrics Authors: Adriana L Ruiz-Rizzo Kathrin Finke Jessica S Damoiseaux Claudia Bartels Katharina Buerger Nicoleta Carmen Cosma Peter Dechent Laura Dobisch Michael Ewers Klaus Fliessbach Ingo Frommann Wenzel Glanz Doreen Goerss Stefan Hetzer Enise I Incesoy Daniel Janowi Source Type: research
Associations between sex, body mass index and the individual microglial response in Alzheimer ’s disease
18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer ’s disease (AD) research. Sex and obesity effects on TSPO-PET binding... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 23, 2024 Category: Neurology Authors: Gloria Biechele, Boris-Stephan Rauchmann, Daniel Janowitz, Katharina Buerger, Nicolai Franzmeier, Endy Weidinger, Selim Guersel, Sebastian Schuster, Anika Finze, Stefanie Harris, Simon Lindner, Nathalie L. Albert, Christian Wetzel, Rainer Rupprecht, Axel Tags: Research Source Type: research
