The 'ins and outs' of Brucella intracellular journey
Curr Opin Microbiol. 2024 Feb 1;78:102427. doi: 10.1016/j.mib.2024.102427. Online ahead of print.ABSTRACTMembers of the genus Brucella are the causative agents of brucellosis, a worldwide zoonosis affecting wild and domestic animals and humans. These facultative intracellular pathogens cause long-lasting chronic infections by evolving sophisticated strategies to counteract, evade, or subvert host bactericidal mechanisms in order to establish a secure replicative niche necessary for their survival. In this review, we present recent findings on selected Brucella effectors to illustrate how this pathogen modulates host cell s...
Source: Current Opinion in Microbiology - February 3, 2024 Category: Microbiology Authors: Mar ía I Marchesini Juan M Spera Diego J Comerci Source Type: research
MicroRNA -21 expression as an auxiliary diagnostic biomarker of acute brucellosis
CONCLUSION: The expression level of miR-21 is significantly augmented in acute brucellosis and has the potential to be a contributing diagnostic factor for acute infection.PMID:38302783 | DOI:10.1007/s11033-023-09193-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - February 1, 2024 Category: Molecular Biology Authors: Mahsa Rezaeepoor Fariba Keramat Sanaz Jourghasemi Mina Rahmanpour Anuja Lipsa Mehrdad Hajilooi Ghasem Solgi Source Type: research
A study on the epidemiology of brucellosis in bovine population of peri-urban and rural areas of district Multan, southern Punjab, Pakistan
Brucellosis is a zoonotic disease caused by a bacterial pathogen belonging to the genus Brucella. It is one of the most frequent bacterial zoonoses globally but unfortunately, it is still considered as a neglecte... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - January 31, 2024 Category: Veterinary Research Authors: Mian Muhammad Awais, Gohar Khadim, Masood Akhtar, Muhammad Irfan Anwar, Abdul Sammad Ali Khan Shirwany, Ahmad Raza, Abdul Razzaq, Zahida Fatima, Muhammad Amjad Ali and Muhammad Sibtain Bhatti Tags: Research Source Type: research
The Reasons Behind Long-Term Endemicity of Brucellosis in Low and Middle-Income Countries: Challenges and Future Perspectives
Curr Microbiol. 2024 Jan 30;81(3):82. doi: 10.1007/s00284-023-03605-5.ABSTRACTBrucellosis is a neglected worldwide zoonotic disease with more than 500,000 new human cases each year. Direct contact with infected animals and consumption of undercooked animal origin foods are the main routes of brucellosis transmission to humans. Although long endeavor has been applied to control and eliminate brucellosis from animal and human populations in developing countries especially in low- and middle-income countries (LMICs), the disease is still endemic in these regions. Many common or unique factors including raw milk consumption, u...
Source: Current Microbiology - January 30, 2024 Category: Microbiology Authors: Assadullah Samadi Mirwais Amiri Nabil Hailat Source Type: research
Gated Nanoprobe Utilizing Metal –Organic Frameworks for Identifying and Distinguishing Between the Wild Strains and the Vaccine Strains of Brucella
Analyst, 2024, Accepted Manuscript DOI: 10.1039/D4AN00014E, PaperDong Li, Shuna Ren, Xiaotong Wang, LIli Chen, Shuang You, Yan Tang, Lihua Chen In the assay for Brucella, the identification and differentiation of wild strains and vaccine strains present a significant challenge. Currently, there may not be any commercially available product to address... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - January 30, 2024 Category: Chemistry Authors: Dong Li Source Type: research
Role of myeloid-derived suppressor cells in chronic brucellosis
ConclusionOur study described an increase of immunosuppressive MDSCs in peripheral blood of chronic brucellosis patients. These results contribute to the understanding of Brucella persistent infection, which may provide an insight for effective treatment of chronic brucellosis patients in clinical practice. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 30, 2024 Category: Microbiology Source Type: research
Editorial: Pathogenomics of the genus Brucella and beyond, volume II
(Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - January 25, 2024 Category: Microbiology Source Type: research
GSE243859 Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+2
Contributors : Mostafa Abushahba ; Skyberg JerodSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe isolated CD4+ T cells from mice vaccinated against, and challenged with, Brucella to investigate the function of CD4+ T cell intrinsic BCL6 signaling (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE243861 Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+4
Contributors : Mostafa Abushahba ; Skyberg JerodSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe isolated CD4+ T cells from mice vaccinated against, and challenged with, Brucella to investigate the function of CD4+ T cell intrinsic BCL6 signaling (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Bystander activation of microglia by Brucella abortus-infected astrocytes induces neuronal death via IL-6 trans-signaling
In this study, we present evidence indicating that soluble factors secreted by Brucella abortus-infected astrocytes activate microglia to induce neuronal death. Culture supernatants (SN) from B. abortus-infected astrocytes induce the release of pro-inflammatory mediators and the increase of the microglial phagocytic capacity, which are two key features in the execution of live neurons by primary phagocytosis, a recently described mechanism whereby B. abortus-activated microglia kills neurons by phagocytosing them. IL-6 neutralization completely abrogates neuronal loss. IL-6 is solely involved in increasing the phagocytic c...
Source: Frontiers in Immunology - January 23, 2024 Category: Allergy & Immunology Source Type: research
A study of rural populations ’ knowledge, attitude, and practice about brucellosis: a descriptive, cross-sectional, multicenter study
Brucellosis is a highly contagious disease which is transmitted from animals to humans. One of the populations at high risk of infection is those living in rural areas. The present study was conducted to inves... (Source: BMC Research Notes)
Source: BMC Research Notes - January 23, 2024 Category: Research Authors: Zahra Montaseri, Zahra Mohebi, Rahil Masoumi, Azizallah Dehghan and Mostafa Bijani Tags: Research Note Source Type: research
Epidemiological changes and molecular characteristics of Brucella strains in Ningxia, China
ConclusionThe epidemic situation of human brucellosis has gradually worsened; the rampant epidemic of the disease has become a regional concern. The present study highlights that implementing the of targeted surveillance and intervention strategies is urge. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - January 19, 2024 Category: Microbiology Source Type: research
In vivo biological validation of in silico analysis: A novel approach for predicting the effects of TLR4 exon 3 polymorphisms on brucellosis
In conclusion, this study combines multidisciplinary approaches to evaluate the biological and structural effects of SNPs on protein function.PMID:38218390 | DOI:10.1016/j.meegid.2024.105552 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 13, 2024 Category: Genetics & Stem Cells Authors: Antonio Gentile Andrea Fulgione Barbara Auzino Valentina Iovane Daniela Gallo Raffaele Garramone Nunzia Iaccarino Antonio Randazzo Giuseppe Iovane Paola Cuomo Rosanna Capparelli Domenico Iannelli Source Type: research
Spatiotemporal dynamics and influencing factors of human brucellosis in Mainland China from 2005 –2021
This study explores the spatial and temporal dynamic evolution of human brucellosis in China and analyses the spatial heterogeneity of the influencing fac... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - January 11, 2024 Category: Infectious Diseases Authors: Meng Zhang, Xinrui Chen, Qingqing Bu, Bo Tan, Tong Yang, Liyuan Qing, Yunna Wang and Dan Deng Tags: Research Source Type: research
What risk do < i > Brucella < /i > vaccines pose to humans? A systematic review of the scientific literature on occupational exposure
ConclusionsBrucella vaccines pose occupational risk of contagion to humans from their production to their administration to livestock, although morbidity is low and deaths were not reported. Recommended protective measures and active surveillance of exposed workers appeared to reduce this risk. It would be advisable to carry out observational studies and/or systematic registries using solid diagnostic criteria. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 8, 2024 Category: Tropical Medicine Authors: Manuel Vives-Soto Source Type: research
