High Frequency of Malignant Transformation of Ovarian Mature Teratoma into Squamous Cell Carcinoma in Young Patients in Northeast Brazil
The malignant behavior of an ovarian teratoma is related to immaturity, or rarely to the malignant transformation of a somatic component in a mature teratoma (MT). The aim of this work was to review 189 consecutive ovarian teratomas diagnosed between 2006 and 2010 at a public referral center for cancer in Brazil, focusing on cases of MT with malignant transformation. MTs with transformation to squamous cell carcinoma (SCC) were further analyzed by immunohistochemistry for p16 staining. The median age of all patients was 36 yr (mean age, 39.6 yr; SD±4.9). Mature and immature teratomas represented 95.7% (181/189) and 4.2% o...
Source: International Journal of Gynecological Pathology - February 11, 2016 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research
[Dualistic classification of epithelial ovarian cancer: Is it clinically relevant?]
Abstract
Malignant epithelial tumors (carcinomas) are the most common ovarian cancers and the most lethal gynecological malignancies. Based on their heterogeneous morphology, a dualistic model of carcinogenesis was proposed in 2004. Type I carcinomas, composed of low grade serous, endometrioid, mucinous, clear cell carcinomas and malignant Brenner tumors, were distinct from type II carcinomas (high grade serous, undifferentiated carcinomas and carcinosarcomas). However, clinical studies failed to demonstrate the prognostic value of such a classification. The main reproach to this dualistic model was that i...
Source: Bulletin du Cancer - February 4, 2016 Category: Cancer & Oncology Authors: Devouassoux-Shisheboran M, Genestie C, Ray-Coquard I Tags: Bull Cancer Source Type: research
Primary ovarian lymphoma and benign Brenner tumor
Primary ovarian lymphomas are rare, accounting for 0.5% of all non-Hodgkin lymphomas and 1.5% of all ovarian neoplasms. A majority of them are diffuse large B cell lymphoma (DLBCL) [1]. Transitional cell tumors are surface epithelial tumors, which include benign, borderline, and malignant Brenner tumors and transitional cell carcinoma, accounting for 1.5% of all ovarian tumors. In 25% of all Brenner tumor cases, a coexisting tumor can be found. The coexisting tumor is usually mucinous cystic tumor, serous cystadenoma, or cystic dermoid teratoma [2]. (Source: Taiwanese Journal of Obstetrics and Gynecology)
Source: Taiwanese Journal of Obstetrics and Gynecology - February 1, 2016 Category: OBGYN Authors: Antonia Pavlovic, Merica Glavina Durdov, Dominik Lozic, Ljubica Skare Librenjak, Darko Alfirevic Tags: Research Letter Source Type: research
Molecular Genetic Analysis of Ovarian Brenner Tumors and Associated Mucinous Epithelial Neoplasms
Benign ovarian Brenner tumors often are associated with mucinous cystic neoplasms, which are hypothesized to share a histogenic origin and progression, however, supporting molecular characterization is limited. Our goal was to identify molecular mechanisms linking these tumors. DNA from six Brenner tumors with paired mucinous tumors, two Brenner tumors not associated with a mucinous neoplasm, and two atypical proliferative (borderline) Brenner tumors was extracted from formalin-fixed, paraffin-embedded tumor samples and sequenced using a 358-gene next-generation sequencing assay. (Source: American Journal of Pathology)
Source: American Journal of Pathology - January 18, 2016 Category: Pathology Authors: Laura J. Tafe, Kristen E. Muller, Guruprasad Ananda, Talia Mitchell, Vanessa Spotlow, Sara E. Patterson, Gregory J. Tsongalis, Susan M. Mockus Tags: Regular Article Source Type: research
Statement by the Kommission Ovar of the AGO: The New FIGO and WHO Classifications of Ovarian, Fallopian Tube and Primary Peritoneal Cancer.
Authors: Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J, Kommission Ovar of the AGO
Abstract
More than 25 years after the last revision, in 2012 the FIGO Oncology Committee began revising the FIGO classification for staging ovarian, Fallopian tube and primary peritoneal cancers. The new classification has become effective with its publication at the beginning of 2014. Following recent findings on the pathogenesis of ovarian, Fallopian tube and primary peritoneal cancer and reflecting standard clinical practice, the three entities have now been classif...
Source: Geburtshilfe und Frauenheilkunde - December 12, 2015 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
Detection of human papillomavirus in squamous cell carcinoma arising from dermoid cysts
Primary squamous cell carcinoma (SCC) of the ovary in humans is rare. Most cases represent a malignant transformation of ovarian teratoma, Brenner tumor, or endometriosis. The etiology of this cancer remains largely unknown. Human papillomavirus (HPV) infection is a critical factor that induces tumor formation, particularly cervical cancer. Therefore, this study aimed to evaluate the association of HPV with malignant transformation of mature cystic teratoma (MCT) into SCC of the ovary. (Source: Taiwanese Journal of Obstetrics and Gynecology)
Source: Taiwanese Journal of Obstetrics and Gynecology - October 1, 2015 Category: OBGYN Authors: An-Jen Chiang, Di-Rong Chen, Jiin-Tsuey Cheng, Tsung-Hsien Chang Tags: Original Article Source Type: research
Malignant ovarian Brenner tumor. A case report evaluated with 18F-FDG PET/CT
Publication date: September–October 2015 Source:Revista Española de Medicina Nuclear e Imagen Molecular (English Edition), Volume 34, Issue 5 Author(s): L.M. Mena, E. Carmona, F.R. Maza, M.V. Guiote, E. Moreno, J.A. Vallejo (Source: Revista Espanola de Medicina Nuclear e Imagen Molecular)
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - August 12, 2015 Category: Nuclear Medicine Source Type: research
Combined benign Brenner tumor and clear cell adenocarcinoma of the ovary
(Source: Pathology International)
Source: Pathology International - July 7, 2015 Category: Pathology Authors: Hirofumi Matsumoto, Takaya Nakanishi, Hajime Aoyama, Masanao Saio, Wataru Kudaka, Yoichi Aoki, Shinichi Teshima, Seiya Kato Tags: Letter to the Editor Source Type: research
Clonality Analysis of Combined Brenner and Mucinous Tumours of the Ovary Reveals Their Monoclonal Origin
In conclusion, this study demonstrates that in combined mucinous and Brenner tumours there is a shared clonal relationship between the two different tumour components and suggests that some pure mucinous tumours may develop from a Brenner tumour in which the Brenner tumour component becomes compressed and obliterated by an expanding mucinous neoplasm. (Source: The Journal of Pathology)
Source: The Journal of Pathology - June 12, 2015 Category: Pathology Authors: Yihong Wang, Ren‐chin Wu, Lauren Ende Shwartz, Lisa Haley, Ming‐tse Lin, Ie‐ming Shih, Robert J. Kurman Tags: Brief Definitive Report Source Type: research
Intensive systemic chemotherapy is effective against recurrent malignant Brenner tumor of the ovary: An analysis of 10 cases within a single center
This study investigated the clinical characteristics of MBTs and the importance of chemotherapy for recurrent disease. (Source: Taiwanese Journal of Obstetrics and Gynecology)
Source: Taiwanese Journal of Obstetrics and Gynecology - April 1, 2015 Category: OBGYN Authors: Ji-Hyun Han, Dae-Yeon Kim, Shin-Wha Lee, Jeong-Yeol Park, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam Tags: Original Article Source Type: research
Different Staining Patterns of Ovarian Brenner Tumor and the Associated Mucinous Tumor
In this study, we analyzed immunohistochemical markers on Brenner tumors and their associated mucinous tumor to explore Müllerian as well as Wolffian and germ cell derivation, and determine if the mucinous component is independent or related to the Brenner tumor. Out of 32 consecutive cases of Brenner tumors, eight were identified with significant mucinous component and 7 additional cases included foci of mucinous epithelium within the Brenner transitional nests. (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - December 20, 2014 Category: Pathology Authors: Andres A. Roma, Ramya P. Masand Tags: Original Contributions Source Type: research
Incidence of Serous Tubal Intraepithelial Carcinoma (STIC) by Algorithm Classification in Serous Ovarian Tumor Associated with PAX8 Expression in Tubal Epithelia: A Study of Single Institution in Japan
Serous ovarian carcinoma is now hypothesized to originate from fallopian tube epithelium (FTE). We investigated the FTE abnormalities in the patients with epithelial ovarian tumors. Our study included 55 cases of serous tumors (24 carcinomas, 8 borderline tumors, and 23 adenomas), 14 mucinous carcinomas, 22 endometrioid carcinomas, 5 clear cell carcinomas, and 2 malignant Brenner tumors. FTE was diagnosed by the diagnostic algorithm, which combines the data of morphology, and p53, Ki-67 immunostaining, as serous tubal intraepithelial carcinoma, serous tubal intraepithelial lesion, p53 signature, and normal/reactive. Serous...
Source: International Journal of Gynecological Pathology - December 8, 2014 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research
Borderline Brenner tumor of the ovary: a case report with immunohistochemical and molecular study
We report a case of a 68-year-old woman, with a right ovarian mass, whose morphology and immuno-profile were consistent with the diagnosis of a borderline Brenner tumor. Immunohistochemistry carried out on selected markers may help to formulate the diagnosis, more than the molecular analyses. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 29, 2014 Category: Cancer & Oncology Authors: Rossella De CecioMonica CantileFrancesca CollinaLaura MarraClemente SantonastasoCono ScaffaGerardo BottiNunzia Losito Source Type: research
Ovarian Brenner Tumors and Walthard Nests: A Histologic and Immunohistochemical study
In this study, we analyzed immunohistochemical markers on Brenner tumors to explore Müllerian as well as Wolffian and germ cell derivation. We also attempted to explore their possible association with tubal/paratubal Walthard nests/transitional metaplasia, using the same immunostains. Thirty-two consecutive cases of Brenner tumors were identified. (Source: Human Pathology)
Source: Human Pathology - August 22, 2014 Category: Pathology Authors: M.D. Andres A. Roma, Ramya P. Masand M.D. Tags: Original contribution Source Type: research
