Large-scale human tissue analysis identifies Uroplakin 1a as a putative diagnostic marker for urothelial cancer
In conclusion, Upk1a immunohistochemistry is a potentially useful and specific diagnostic marker for the distinction of urothelial carcinomas from other neoplasms. However, its sensitivity is less than 50 % in muscle-invasive cancers because Upk1a expression decreases during grade and stage progression.PMID:35872365 | DOI:10.1016/j.prp.2022.154028 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 25, 2022 Category: Pathology Authors: Viktor Reiswich Steffi K önemann Maximilian Lennartz Doris H öflmayer Anne Menz Viktoria Chirico Claudia Hube-Magg Christoph Fraune Christian Bernreuther Ronald Simon Till S Clauditz Guido Sauter Andrea Hinsch Simon Kind Frank Jacobsen Stefan Steurer Sa Source Type: research

Large-scale human tissue analysis identifies Uroplakin 1a as a putative diagnostic marker for urothelial cancer
In conclusion, Upk1a immunohistochemistry is a potentially useful and specific diagnostic marker for the distinction of urothelial carcinomas from other neoplasms. However, its sensitivity is less than 50 % in muscle-invasive cancers because Upk1a expression decreases during grade and stage progression.PMID:35872365 | DOI:10.1016/j.prp.2022.154028 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 25, 2022 Category: Pathology Authors: Viktor Reiswich Steffi K önemann Maximilian Lennartz Doris H öflmayer Anne Menz Viktoria Chirico Claudia Hube-Magg Christoph Fraune Christian Bernreuther Ronald Simon Till S Clauditz Guido Sauter Andrea Hinsch Simon Kind Frank Jacobsen Stefan Steurer Sa Source Type: research

Large-scale human tissue analysis identifies Uroplakin 1a as a putative diagnostic marker for urothelial cancer
In conclusion, Upk1a immunohistochemistry is a potentially useful and specific diagnostic marker for the distinction of urothelial carcinomas from other neoplasms. However, its sensitivity is less than 50 % in muscle-invasive cancers because Upk1a expression decreases during grade and stage progression.PMID:35872365 | DOI:10.1016/j.prp.2022.154028 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 25, 2022 Category: Pathology Authors: Viktor Reiswich Steffi K önemann Maximilian Lennartz Doris H öflmayer Anne Menz Viktoria Chirico Claudia Hube-Magg Christoph Fraune Christian Bernreuther Ronald Simon Till S Clauditz Guido Sauter Andrea Hinsch Simon Kind Frank Jacobsen Stefan Steurer Sa Source Type: research

Large-scale human tissue analysis identifies Uroplakin 1a as a putative diagnostic marker for urothelial cancer
In conclusion, Upk1a immunohistochemistry is a potentially useful and specific diagnostic marker for the distinction of urothelial carcinomas from other neoplasms. However, its sensitivity is less than 50 % in muscle-invasive cancers because Upk1a expression decreases during grade and stage progression.PMID:35872365 | DOI:10.1016/j.prp.2022.154028 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 25, 2022 Category: Pathology Authors: Viktor Reiswich Steffi K önemann Maximilian Lennartz Doris H öflmayer Anne Menz Viktoria Chirico Claudia Hube-Magg Christoph Fraune Christian Bernreuther Ronald Simon Till S Clauditz Guido Sauter Andrea Hinsch Simon Kind Frank Jacobsen Stefan Steurer Sa Source Type: research

Coexistence of malignant ovarian Brenner tumor and borderline mucinous cystadenoma, combined with primary uterine corpus endometrioid carcinoma: A case report and literature review
Oncol Lett. 2022 Jun 22;24(2):272. doi: 10.3892/ol.2022.13392. eCollection 2022 Aug.ABSTRACTMalignant Brenner tumor (MBT) of the ovary is a rare malignant ovarian tumor, whereas uterine corpus endometrioid carcinoma (UEC) constitutes one of the most common malignant tumors of the female reproductive system. The present study reported on a case of the coexistence of ovarian MBT and borderline mucinous cystadenoma combined with primary UEC. Therefore, the present case is a synchronous primary cancer of both ovary and endometrium. Although synchronous primary cancers of the endometrium and ovary are relatively uncommon, they ...
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Cancan Zou Qiong Li Jingbo Zhao Yanlin Chen Source Type: research

Ovarian Low-grade Basaloid Carcinoma Arising in Brenner Tumor: A New Variant of Malignant Brenner Tumor
We report 2 unusual ovarian neoplasms composed of an admixture of typical benign Brenner tumor and a low-grade epithelial neoplasm which we designate as low-grade basaloid carcinoma. The latter component morphologically and immunohistochemically resembled “salivary gland-type/myoepithelial” neoplasms with variable positive staining with cytokeratins, p63, S100, and CD117. One tumor exhibited aggressive behavior with local recurrence and distant metastasis. This neoplasm exhibited focal “high-grade” transformation with diffuse mutation-type p53 staining, in contrast to the wild-type immunoreactivity in the low-grade...
Source: International Journal of Gynecological Pathology - April 25, 2022 Category: Pathology Tags: Pathology of the Upper Tract: Original Articles Source Type: research

Brenner tumors
Br J Radiol. 2021 Dec 20:20210687. doi: 10.1259/bjr.20210687. Online ahead of print.ABSTRACTBrenner tumors are rare ovarian neoplasms composed of ovarian transition cells surrounded by dense fibrous tissue. Most of them are small tumors (<2 cm), detected incidentally in asymptomatic women. Its predominantly fibrous content results in relatively low signal on T2 weighted images, establishing differential diagnosis with ovarian fibroma and thecoma. Their imaging features are very similar, the differentiation is based on secondary characteristics, such as signs or symptoms of estrogen excess and the presence of a second ov...
Source: The British Journal of Radiology - December 20, 2021 Category: Radiology Authors: Filipa de Sousa Costeira Ana F élix Teresa Margarida Cunha Source Type: research

Brenner tumors
Br J Radiol. 2021 Dec 20:20210687. doi: 10.1259/bjr.20210687. Online ahead of print.ABSTRACTBrenner tumors are rare ovarian neoplasms composed of ovarian transition cells surrounded by dense fibrous tissue. Most of them are small tumors (<2 cm), detected incidentally in asymptomatic women. Its predominantly fibrous content results in relatively low signal on T2 weighted images, establishing differential diagnosis with ovarian fibroma and thecoma. Their imaging features are very similar, the differentiation is based on secondary characteristics, such as signs or symptoms of estrogen excess and the presence of a second ov...
Source: The British Journal of Radiology - December 20, 2021 Category: Radiology Authors: Filipa de Sousa Costeira Ana F élix Teresa Margarida Cunha Source Type: research

Benign Brenner Tumor in an Ectopic Ovary: A Case Report and Review of Literature
Supernumerary ectopic ovaries are very rare, with fewer than 40 cases of isolated supernumerary ovaries reported in the literature since their discovery in 1864. Tumors arising in ectopic ovaries are also extremely rare, with only a handful of reports in the literature. Given the rarity of this combination of findings, we report a case of a 68-yr-old woman incidentally found to have a 4.7 cm solid retroperitoneal mass adjacent to the liver, diagnosed as a benign Brenner tumor arising in a supernumerary ectopic ovary. To our knowledge, there has been only one previously reported case of Brenner tumor arising in this unusu...
Source: International Journal of Gynecological Pathology - June 11, 2021 Category: Pathology Tags: PATHOLOGY OF THE UPPER TRACT: Case Reports Source Type: research

Benign Brenner tumour of the ovary: CT and MRI features
To evaluate the computed tomography (CT) and magnetic resonance imaging (MRI) features of benign Brenner tumours (BBT) of the ovary. (Source: Clinical Radiology)
Source: Clinical Radiology - April 28, 2021 Category: Radiology Authors: P.-F. Montoriol, C. Hordonneau, C. Boudinaud, I. Molnar, C. Abrial, M. Kossai Source Type: research

Brenner Borderline Ovarian Tumor: A Case Series and Literature Review
CONCLUSIONS: Peritoneal staging surgery is not required because all patients reported had stage I disease. One recurrence occurred. When reviewing all the 82 cases reported in the literature (including ours), 9% had previous history or synchronous urothelial tumor, suggesting the need to carefully check for urological disease in patients with BBOT.PMID:33768396 | DOI:10.1245/s10434-021-09879-y (Source: Ann Oncol)
Source: Ann Oncol - March 26, 2021 Category: Cancer & Oncology Authors: Giulio Ricotta Amandine Maulard Catherine Genestie Patricia Pautier Alexandra Leary Cyrus Chargari Massimo Candiani Philippe Morice Sebastien Gouy Source Type: research