Gene expression profiling of mucinous ovarian tumors and comparison with upper and lower gastrointestinal tumors identifies markers associated with adverse outcomes
CONCLUSIONS: An infiltrative growth pattern infers poor prognosis within 2-years from diagnosis and may help select Stage I patients for adjuvant therapy. High expression of THBS2 and TAGLN in MOC confer an adverse prognosis and is upregulated in the infiltrative subtype which warrants further investigation. Anti-HER2 therapy should be investigated in a subset of patients. MOC samples clustered with upper GI, yet markers to differentiate these entities remain elusive, suggesting similar underlying biology and shared treatment strategies.PMID:36222710 | DOI:10.1158/1078-0432.CCR-22-1206 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 12, 2022 Category: Cancer & Oncology Authors: Nicola S Meagher Kylie L Gorringe Matthew J Wakefield Adelyn Bolithon Chi Nam Ignatius Pang Derek S Chiu Michael S Anglesio Kylie-Ann Mallitt Jennifer A Doherty Holly R Harris Joellen M Schildkraut Andrew Berchuck Kara L Cushing-Haugen Ksenia Chezar Angel Source Type: research
Gene expression profiling of mucinous ovarian tumors and comparison with upper and lower gastrointestinal tumors identifies markers associated with adverse outcomes
CONCLUSIONS: An infiltrative growth pattern infers poor prognosis within 2-years from diagnosis and may help select Stage I patients for adjuvant therapy. High expression of THBS2 and TAGLN in MOC confer an adverse prognosis and is upregulated in the infiltrative subtype which warrants further investigation. Anti-HER2 therapy should be investigated in a subset of patients. MOC samples clustered with upper GI, yet markers to differentiate these entities remain elusive, suggesting similar underlying biology and shared treatment strategies.PMID:36222710 | DOI:10.1158/1078-0432.CCR-22-1206 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 12, 2022 Category: Cancer & Oncology Authors: Nicola S Meagher Kylie L Gorringe Matthew J Wakefield Adelyn Bolithon Chi Nam Ignatius Pang Derek S Chiu Michael S Anglesio Kylie-Ann Mallitt Jennifer A Doherty Holly R Harris Joellen M Schildkraut Andrew Berchuck Kara L Cushing-Haugen Ksenia Chezar Angel Source Type: research
Management of borderline ovarian tumors: A tertiary referral center experience in Egypt
CONCLUSION: Borderline ovarian tumors still represent a dilemma either in diagnosis or management. A frozen section examination could help to reach a preliminary diagnosis. Total abdominal hysterectomy and bilateral salpingo-oophorectomy are the cornerstone of surgical management; however, fertility-sparing surgery could be a valid option for women desiring fertility.PMID:36117821 | PMC:PMC9478369 | DOI:10.3389/fsurg.2022.962820 (Source: Hand Surgery)
Source: Hand Surgery - September 19, 2022 Category: Surgery Authors: Khaled Gaballa Mohamed Abdelkhalek Adel Fathi Basel Refky Khaled Belal Moustafa Elaraby Mohammad Zuhdy Source Type: research
Low BRCA1/2 germline mutation rate in a French-Canadian population with a diagnosis of epithelial tubo-ovarian carcinoma
CONCLUSION: In our French-Canadian population, the incidence of deleterious germline BRCA mutations was surprisingly low at 5.4%-less than half that reported in the literature. This may affect patient response to poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) therapy. Mainstream genetic testing was successfully implemented in our service and facilitated access to genetic testing in our patient population.PMID:35948169 | DOI:10.1016/j.jogc.2022.06.012 (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - August 10, 2022 Category: OBGYN Authors: Submission Cover Page Juliette Bernard Wala Mehros Jean Gregoire Alexandra Sebastianelli Marie-Claude Renaud Pierre Douville Eve-Lyne Langlais Marie Plante Source Type: research
Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice
AbstractThere are many types of ovarian tumors, and these different types often form cystic masses with a similar appearance, which can make their differentiation difficult. However, with the exclusion of rare ovarian tumors, the number of ovarian tumors encountered in daily practice is somewhat fixed. It goes without saying that magnetic resonance imaging (MRI) is useful for differentiating ovarian tumors. In this review, we summarize the differential diagnoses for each of the five types of MRI findings commonly encountered in daily practice. First, unilocular cystic masses without mural nodules/solid components include b...
Source: Japanese Journal of Radiology - August 2, 2022 Category: Radiology Source Type: research
Postmenopausal giant ovarian tumor: a rare case report and literature review
Conclusions
The high incidence of severe complications should be carefully considered when huge ovarian tumors or tumors containing a large amount of tumor fluid in postmenopausal women are removed. (Source: Menopause)
Source: Menopause - July 30, 2022 Category: OBGYN Tags: Case Report Source Type: research
Mucinous Tumor Coexisting With Mesonephric-like Proliferation/Tumor in the Ovary: A Novel Association
We report 4 cases of ovarian mucinous tumors (1 mucinous cystadenofibroma and 3 mucinous borderline tumors/atypical proliferative mucinous tumors [MBT/APMT]) co-existing with mesonephric-like lesions which were highlighted by Gata3 and Pax8 expression. All cases contained benign mesonephric-like proliferations (MLP) which focally displayed gastrointestinal-type mucinous metaplasia/differentiation and some were intimately admixed with mucinous glands associated with the mucinous tumor. Metaplastic mucinous epithelium retained expression of Gata3 and Pax8 in some areas while 1 mucinous cystadenofibroma and 1 MBT/APMT were fo...
Source: The American Journal of Surgical Pathology - July 25, 2022 Category: Pathology Tags: Original Articles Source Type: research
Coexistence of malignant ovarian Brenner tumor and borderline mucinous cystadenoma, combined with primary uterine corpus endometrioid carcinoma: A case report and literature review
Oncol Lett. 2022 Jun 22;24(2):272. doi: 10.3892/ol.2022.13392. eCollection 2022 Aug.ABSTRACTMalignant Brenner tumor (MBT) of the ovary is a rare malignant ovarian tumor, whereas uterine corpus endometrioid carcinoma (UEC) constitutes one of the most common malignant tumors of the female reproductive system. The present study reported on a case of the coexistence of ovarian MBT and borderline mucinous cystadenoma combined with primary UEC. Therefore, the present case is a synchronous primary cancer of both ovary and endometrium. Although synchronous primary cancers of the endometrium and ovary are relatively uncommon, they ...
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Cancan Zou Qiong Li Jingbo Zhao Yanlin Chen Source Type: research
