Accuracy of Frozen Section and Clinical/Radiological Diagnosis with Final Histopathology of Pelvic Masses in a Teaching Institute with a Non-oncology Setup, in Northeast India
ConclusionNon-oncology centers are burdened with variety of benign surgeries, hence, FS is effective in detecting malignancy in ovarian tumors but not so in large uterine masses. Performing FS prevents “lost to follow ups” in ovarian tumors while avoiding it, saves time of experts while dealing with large uterine masses. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - June 29, 2023 Category: OBGYN Source Type: research
Primary retroperitoneal mucinous cystic neoplasm of borderline malignancy with < em > KRAS < /em > and < em > GNAS < /em > co-mutation: a case report
We describe an additional male patient with PRMCN-BM. A 39-year-old man presented to our hospital with back pain. Twelve years earlier, he had undergone an orchiectomy for a germ cell tumor. Computed tomography showed a 6.9- × 4.4-cm cystic mass in the left pararenal space. Laparoscopic mass excision was performed, and a unilocular cystic mass was found in the pararenal space near the lower pole of the left kidney. A histopathological examination showed a cyst lined by atypical mucinous intestinal epithelium without stromal invasion. Targeted next-generation sequencing identified two hotspot mutations, with one each in th...
Source: Cell Research - May 18, 2023 Category: Cytology Authors: Seung-Myoung Son Chang Gok Woo Seok Jung Yun Ok-Jun Lee Source Type: research
Histological and Genetic Diversity in Ovarian Mucinous Carcinomas: A Pilot Study
This study aimed to elucidate the genetic changes histologically (mucinous cystadenoma (MCA), mucinous borderline tumor (MBT), and mucinous ovarian carcinoma (MOC)) in a portion of mucinous ovarian tumors within the same sample. Seven tumor samples obtained from different patients were used to evaluate the genetic mutations in each component. Intratumor genetic heterogeneity was observed in all patients; among them, BRAF (V600E) and p53 (T118I, P142S, T150I, and T170M) point mutations were observed in the MBT component, while KRAS (G12D and G13D) and PIK3CA (E545K) mutations were found in the MOC component. The current fin...
Source: Current Oncology - May 15, 2023 Category: Cancer & Oncology Authors: Sultana Razia Kentaro Nakayama Hitomi Yamashita Tomoka Ishibashi Masako Ishikawa Kosuke Kanno Seiya Sato Satoru Kyo Source Type: research
Histological and Genetic Diversity in Ovarian Mucinous Carcinomas: A Pilot Study
This study aimed to elucidate the genetic changes histologically (mucinous cystadenoma (MCA), mucinous borderline tumor (MBT), and mucinous ovarian carcinoma (MOC)) in a portion of mucinous ovarian tumors within the same sample. Seven tumor samples obtained from different patients were used to evaluate the genetic mutations in each component. Intratumor genetic heterogeneity was observed in all patients; among them, BRAF (V600E) and p53 (T118I, P142S, T150I, and T170M) point mutations were observed in the MBT component, while KRAS (G12D and G13D) and PIK3CA (E545K) mutations were found in the MOC component. The current fin...
Source: Current Oncology - May 15, 2023 Category: Cancer & Oncology Authors: Sultana Razia Kentaro Nakayama Hitomi Yamashita Tomoka Ishibashi Masako Ishikawa Kosuke Kanno Seiya Sato Satoru Kyo Source Type: research
