Obstetric outcomes after conservative management of ovarian borderline tumors in women of reproductive age: A single center experience
CONCLUSIONS: Fertility-sparing surgery should be proposed to young women wishing to preserve fertility. The rate of spontaneous pregnancy is approximately 50%.The risk of relapse is significant but always of borderline histology and may be successfully treated by the second surgery.PMID:34998079 | DOI:10.1016/j.ejogrb.2021.12.029 (Source: Reproductive Biology)
Source: Reproductive Biology - January 8, 2022 Category: Reproduction Medicine Authors: Piotr Sobiczewski Szymon Piatek Wojciech Michalski Jolanta Kupryja ńczyk Tomasz Maciejewski Mariusz O łtarzewski Mariusz Bidzinski Source Type: research

Gastric-type endocervical adenocarcinoma with mucoepithelial metaplasia combined with a serous borderline tumor: A case report
Rationale: Gastric-type endocervical adenocarcinoma (GAS) is a rare type of cervical adenocarcinoma that is a mucinous adenocarcinoma with a variety of gastral patterns. To date, there are no systematic clinical diagnosis and treatment guidelines. Patient concerns: In our case, a 49-year-old woman underwent pelvic magnetic resonance imaging (MRI) due to a pelvic mass, and cervical lesions were unexpectedly found. After receiving relevant surgical treatment, the pathological results showed the particularity of the tumor type—cervical gastric adenocarcinoma with a borderline serous tumor of both appendages a...
Source: Medicine - December 23, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Primary female genital system lymphoma complicated by a recurrent mucinous borderline ovarian tumor: a case report and review of the literature
Primary female genital system lymphoma (PFGSL) is an infrequent entity. All genital organs may be affected, and most PFGSLs are localized to the cervix, uterine body, and ovaries. The clinical manifestations a... (Source: BMC Women's Health)
Source: BMC Women's Health - December 18, 2021 Category: OBGYN Authors: Erqiu Du, Xiangdong Qu, Wei Xu and Hongsheng Lu Tags: Case report Source Type: research

Müllerian Mucinous Cystadenomas of the Ovary: A Report of 25 Cases of an Unheralded Benign Ovarian Neoplasm Often Associated With Endometriosis and a Brief Consideration of Neoplasms Arising From the Latter
A subset of ovarian mucinous tumors demonstrates müllerian-type epithelium, with such lesions variably designated “endocervical-like” and seromucinous since their popularization based on a report of borderline examples in 1989. While müllerian mucinous borderline tumors and carcinomas have been highlighted in the literature, there has been minimal attention given to benign müllerian mucinous tumors, particularly müllerian mucinous cystadenomas. Given the paucity of literature describing the features of müllerian mucinous cystadenomas/cystadenofibromas, diagnostic difficulties may arise ...
Source: International Journal of Gynecological Pathology - December 17, 2021 Category: Pathology Tags: Pathology of the Upper Tract: Original Articles Source Type: research

Prognosis in primary mucinous ovarian carcinoma: focusing on the five pathological findings indicating metastatic mucinous carcinoma to the ovary
In this study, we investigated the pathological features indicating MMCO in a large cohort of PMOCs and analyzed their association with patient prognosis.METHODS: We reviewed surgically treated PMOC patients diagnosed at the Seoul National University Hospital from 1995 to 2019, according to the updated WHO classification, and investigated the presence of pathological features indicating MMCO.RESULTS: A total of 144 patients with PMOCs were included. The 5 pathological findings indicating MMCO, including an infiltrative invasive pattern, the absence of benign or borderline components, a smaller tumor size, the presence of s...
Source: Journal of Gynecologic Oncology - December 15, 2021 Category: OBGYN Authors: Sang Won Lee Jung-A Sung Minsun Jung Haeryoung Kim Cheol Lee Source Type: research

MRI characteristics for differentiating mucinous borderline ovarian tumours from mucinous ovarian cancers
To investigate the magnetic resonance imaging (MRI) characteristics that could differentiate mucinous borderline ovarian tumours (MBOTs) from mucinous ovarian cancers (MOCs). (Source: Clinical Radiology)
Source: Clinical Radiology - November 27, 2021 Category: Radiology Authors: X.Y. Yang, X. Li, F.H. Ma, H.M. Li, S.H. Zhao, Y.A. Li, J.W. Qiang Source Type: research

Progression of Cystadenoma to Mucinous Borderline Ovarian Tumor in Young Females: Case Series and Literature Review
To study the progression of benign ovarian lesions to mucinous borderline ovarian tumors (mBOTs); analyze the clinicopathologic features, diagnosis, and management of mBOTs in pediatric and adolescent girls; and provide a review of the literature on mBOTs in this population. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - November 26, 2021 Category: OBGYN Authors: Gabriela Beroukhim, Doruk Ozgediz, Paul J. Cohen, Pei Hui, Raffaella Morotti, Peter E. Schwartz, Yang Yang-Hartwich, Alla Vash-Margita Source Type: research

Cancers, Vol. 13, Pages 5713: Targeted Selected Reaction Monitoring Verifies Histology Specific Peptide Signatures in Epithelial Ovarian Cancer
Karin Sundfeldt Epithelial ovarian cancer (OC) is a disease with high mortality due to vague early clinical symptoms. Benign ovarian cysts are common and accurate diagnosis remains a challenge because of the molecular heterogeneity of OC. We set out to investigate whether the disease diversity seen in ovarian cyst fluids and tumor tissue could be detected in plasma. Using existing mass spectrometry (MS)-based proteomics data, we constructed a selected reaction monitoring (SRM) assay targeting peptides from 177 cancer-related and classical proteins associated with OC. Plasma from benign, borderline, and malignant ovaria...
Source: Cancers - November 15, 2021 Category: Cancer & Oncology Authors: Leena Liljedahl Johan Malmstr öm Bj örg Kristjansdottir Sofia Waldemarson Karin Sundfeldt Tags: Article Source Type: research

Neoadjuvant Chemotherapy Switch in Borderline Resectable/Locally Advanced Pancreatic Cancer
Ann Surg Oncol. 2021 Nov 1. doi: 10.1245/s10434-021-10991-2. Online ahead of print.ABSTRACTBACKGROUND: Neoadjuvant chemotherapy (NAC) is an integral part of preoperative treatment for patients with borderline resectable/locally advanced (BR/LA) pancreatic ductal adenocarcinoma (PDAC). The identification of a chemotherapeutic regimen that is both effective and tolerable is critical for NAC to be of oncologic benefit. After initial first-line (FL) NAC, some patients have lack of response or therapeutic toxicities precluding further treatment with the same regimen; optimal decision making regarding this patient population is ...
Source: Ann Oncol - November 1, 2021 Category: Cancer & Oncology Authors: Roberto Alva-Ruiz Lavanya Yohanathan Jennifer A Yonkus Amro M Abdelrahman Lindsey A Gregory Thorvadur R Halfdanarson Amit Mahipal Robert R McWilliams Wen Wee Ma Christopher L Hallemeier Rondell P Graham Travis E Grotz Rory L Smoot Sean P Cleary David M Na Source Type: research

Neoadjuvant Chemotherapy Switch in Borderline Resectable/Locally Advanced Pancreatic Cancer
Ann Surg Oncol. 2021 Nov 1. doi: 10.1245/s10434-021-10991-2. Online ahead of print.ABSTRACTBACKGROUND: Neoadjuvant chemotherapy (NAC) is an integral part of preoperative treatment for patients with borderline resectable/locally advanced (BR/LA) pancreatic ductal adenocarcinoma (PDAC). The identification of a chemotherapeutic regimen that is both effective and tolerable is critical for NAC to be of oncologic benefit. After initial first-line (FL) NAC, some patients have lack of response or therapeutic toxicities precluding further treatment with the same regimen; optimal decision making regarding this patient population is ...
Source: Ann Oncol - November 1, 2021 Category: Cancer & Oncology Authors: Roberto Alva-Ruiz Lavanya Yohanathan Jennifer A Yonkus Amro M Abdelrahman Lindsey A Gregory Thorvadur R Halfdanarson Amit Mahipal Robert R McWilliams Wen Wee Ma Christopher L Hallemeier Rondell P Graham Travis E Grotz Rory L Smoot Sean P Cleary David M Na Source Type: research

Fertility-Sparing Surgery for Ovarian Cancer
J Clin Med. 2021 Sep 18;10(18):4235. doi: 10.3390/jcm10184235.ABSTRACT(1) Background: although most patients with epithelial ovarian cancer (EOC) undergo radical surgery, patients with early-stage disease, borderline ovarian tumor (BOT) or a non-epithelial tumor could be offered fertility-sparing surgery (FSS) depending on histologic subtypes and prognostic factors. (2) Methods: we conducted a systematic review to assess the safety and fertility outcomes of FSS in the treatment of ovarian cancer. We queried the MEDLINE, PubMed, Cochrane Library, and Cochrane ("Cochrane Reviews") databases for articles published i...
Source: Clinical Breast Cancer - September 28, 2021 Category: Cancer & Oncology Authors: Geoffroy Canlorbe Nathalie Chabbert-Buffet Catherine Uzan Source Type: research

Fertility-Sparing Surgery for Ovarian Cancer
J Clin Med. 2021 Sep 18;10(18):4235. doi: 10.3390/jcm10184235.ABSTRACT(1) Background: although most patients with epithelial ovarian cancer (EOC) undergo radical surgery, patients with early-stage disease, borderline ovarian tumor (BOT) or a non-epithelial tumor could be offered fertility-sparing surgery (FSS) depending on histologic subtypes and prognostic factors. (2) Methods: we conducted a systematic review to assess the safety and fertility outcomes of FSS in the treatment of ovarian cancer. We queried the MEDLINE, PubMed, Cochrane Library, and Cochrane ("Cochrane Reviews") databases for articles published i...
Source: Clinical Genitourinary Cancer - September 28, 2021 Category: Cancer & Oncology Authors: Geoffroy Canlorbe Nathalie Chabbert-Buffet Catherine Uzan Source Type: research

Fertility-Sparing Surgery for Ovarian Cancer
J Clin Med. 2021 Sep 18;10(18):4235. doi: 10.3390/jcm10184235.ABSTRACT(1) Background: although most patients with epithelial ovarian cancer (EOC) undergo radical surgery, patients with early-stage disease, borderline ovarian tumor (BOT) or a non-epithelial tumor could be offered fertility-sparing surgery (FSS) depending on histologic subtypes and prognostic factors. (2) Methods: we conducted a systematic review to assess the safety and fertility outcomes of FSS in the treatment of ovarian cancer. We queried the MEDLINE, PubMed, Cochrane Library, and Cochrane ("Cochrane Reviews") databases for articles published i...
Source: Clinical Breast Cancer - September 28, 2021 Category: Cancer & Oncology Authors: Geoffroy Canlorbe Nathalie Chabbert-Buffet Catherine Uzan Source Type: research

Fertility-Sparing Surgery for Ovarian Cancer
J Clin Med. 2021 Sep 18;10(18):4235. doi: 10.3390/jcm10184235.ABSTRACT(1) Background: although most patients with epithelial ovarian cancer (EOC) undergo radical surgery, patients with early-stage disease, borderline ovarian tumor (BOT) or a non-epithelial tumor could be offered fertility-sparing surgery (FSS) depending on histologic subtypes and prognostic factors. (2) Methods: we conducted a systematic review to assess the safety and fertility outcomes of FSS in the treatment of ovarian cancer. We queried the MEDLINE, PubMed, Cochrane Library, and Cochrane ("Cochrane Reviews") databases for articles published i...
Source: Clinical Genitourinary Cancer - September 28, 2021 Category: Cancer & Oncology Authors: Geoffroy Canlorbe Nathalie Chabbert-Buffet Catherine Uzan Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research

Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (bor...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research