Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 are...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research
Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 are...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research
Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 are...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research
Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 are...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research
Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 are...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research
Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 are...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research
Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 are...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research
Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 are...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research
Decreased Gastric Gland Mucin-specific < em > O < /em > -glycans Are Involved in the Progression of Ovarian Primary Mucinous Tumours
Acta Histochem Cytochem. 2021 Aug 25;54(4):115-122. doi: 10.1267/ahc.21-00032. Epub 2021 Jul 7.ABSTRACTOvarian primary mucinous tumours (OPMTs) show an adenoma-borderline-carcinoma sequence with gastrointestinal metaplasia. Gastric gland mucin-specific O-glycans are unique with an α1,4-linked N-acetylglucosamine (αGlcNAc) residue attached to mucin 6 (MUC6). Although αGlcNAc is expected to be expressed in OPMTs, the relationship between αGlcNAc expression and OPMT progression remains unknown. Here, we analysed 104 areas of benign mucinous tumours (benign), 55 areas of borderline mucinous tumours (borderline), and 18 are...
Source: Acta Histochemica et Cytochemica - September 13, 2021 Category: Biochemistry Authors: Ayumi Ohya Hisanori Matoba Yasunari Fujinaga Jun Nakayama Source Type: research
Moderately differentiated Sertoli-Leydig cell tumor of ovary with associated mucinous carcinoma and carcinoid-A case report and review of literature
We report a case of a 22-year-old woman who presented with complaints of lower abdominal pain and secondary amenorrhea for 10 months. Physical examination revealed right lower abdominal tenderness and fullness. Imaging showed a right ovarian mass. She underwent right salpingo-oophorectomy with bilateral pelvic lymphadenectomy and omentectomy. Microscopic examination revealed a neoplasm with varied histomorphological patterns. The predominant pattern was an atypical proliferative mucinous tumor with foci of microinvasion. The other component was that of moderately differentiated Sertoli-Leydig Cell Tumor. Focal areas resemb...
Source: Indian Journal of Pathology and Microbiology - August 3, 2021 Category: Pathology Authors: Aarthiprabha Ravichandaran Archana Lakshmanan Ann Kurian Srikala Prasad Source Type: research
Moderately differentiated Sertoli-Leydig cell tumor of ovary with associated mucinous carcinoma and carcinoid-A case report and review of literature
We report a case of a 22-year-old woman who presented with complaints of lower abdominal pain and secondary amenorrhea for 10 months. Physical examination revealed right lower abdominal tenderness and fullness. Imaging showed a right ovarian mass. She underwent right salpingo-oophorectomy with bilateral pelvic lymphadenectomy and omentectomy. Microscopic examination revealed a neoplasm with varied histomorphological patterns. The predominant pattern was an atypical proliferative mucinous tumor with foci of microinvasion. The other component was that of moderately differentiated Sertoli-Leydig Cell Tumor. Focal areas resemb...
Source: Indian Journal of Pathology and Microbiology - August 3, 2021 Category: Pathology Authors: Aarthiprabha Ravichandaran Archana Lakshmanan Ann Kurian Srikala Prasad Source Type: research
Moderately differentiated Sertoli-Leydig cell tumor of ovary with associated mucinous carcinoma and carcinoid-A case report and review of literature
We report a case of a 22-year-old woman who presented with complaints of lower abdominal pain and secondary amenorrhea for 10 months. Physical examination revealed right lower abdominal tenderness and fullness. Imaging showed a right ovarian mass. She underwent right salpingo-oophorectomy with bilateral pelvic lymphadenectomy and omentectomy. Microscopic examination revealed a neoplasm with varied histomorphological patterns. The predominant pattern was an atypical proliferative mucinous tumor with foci of microinvasion. The other component was that of moderately differentiated Sertoli-Leydig Cell Tumor. Focal areas resemb...
Source: Indian Journal of Pathology and Microbiology - August 3, 2021 Category: Pathology Authors: Aarthiprabha Ravichandaran Archana Lakshmanan Ann Kurian Srikala Prasad Source Type: research
Moderately differentiated Sertoli-Leydig cell tumor of ovary with associated mucinous carcinoma and carcinoid-A case report and review of literature
We report a case of a 22-year-old woman who presented with complaints of lower abdominal pain and secondary amenorrhea for 10 months. Physical examination revealed right lower abdominal tenderness and fullness. Imaging showed a right ovarian mass. She underwent right salpingo-oophorectomy with bilateral pelvic lymphadenectomy and omentectomy. Microscopic examination revealed a neoplasm with varied histomorphological patterns. The predominant pattern was an atypical proliferative mucinous tumor with foci of microinvasion. The other component was that of moderately differentiated Sertoli-Leydig Cell Tumor. Focal areas resemb...
Source: Indian Journal of Pathology and Microbiology - August 3, 2021 Category: Pathology Authors: Aarthiprabha Ravichandaran Archana Lakshmanan Ann Kurian Srikala Prasad Source Type: research
Moderately differentiated Sertoli-Leydig cell tumor of ovary with associated mucinous carcinoma and carcinoid-A case report and review of literature
We report a case of a 22-year-old woman who presented with complaints of lower abdominal pain and secondary amenorrhea for 10 months. Physical examination revealed right lower abdominal tenderness and fullness. Imaging showed a right ovarian mass. She underwent right salpingo-oophorectomy with bilateral pelvic lymphadenectomy and omentectomy. Microscopic examination revealed a neoplasm with varied histomorphological patterns. The predominant pattern was an atypical proliferative mucinous tumor with foci of microinvasion. The other component was that of moderately differentiated Sertoli-Leydig Cell Tumor. Focal areas resemb...
Source: Indian Journal of Pathology and Microbiology - August 3, 2021 Category: Pathology Authors: Aarthiprabha Ravichandaran Archana Lakshmanan Ann Kurian Srikala Prasad Source Type: research
Moderately differentiated Sertoli-Leydig cell tumor of ovary with associated mucinous carcinoma and carcinoid-A case report and review of literature
We report a case of a 22-year-old woman who presented with complaints of lower abdominal pain and secondary amenorrhea for 10 months. Physical examination revealed right lower abdominal tenderness and fullness. Imaging showed a right ovarian mass. She underwent right salpingo-oophorectomy with bilateral pelvic lymphadenectomy and omentectomy. Microscopic examination revealed a neoplasm with varied histomorphological patterns. The predominant pattern was an atypical proliferative mucinous tumor with foci of microinvasion. The other component was that of moderately differentiated Sertoli-Leydig Cell Tumor. Focal areas resemb...
Source: Indian Journal of Pathology and Microbiology - August 3, 2021 Category: Pathology Authors: Aarthiprabha Ravichandaran Archana Lakshmanan Ann Kurian Srikala Prasad Source Type: research
