LEV Foundation on Senolytics as One Part of a Combination Rejuvenation Therapy
The primary focus of the Longevity Escape Velocity (LEV) Foundation is to demonstrate that therapies based on the repair of forms of underlying molecular damage that cause aging can be combined to produce greater rejuvenation. Research of recent years has demonstrated quite comprehensively that the alternative strategy for treating aging, to manipulate metabolism into a state in which aging occurs modestly more slowly, has so far produced therapies that largely cannot be combined. The combination of any two or more metabolic alterations, induced by supplements or other small molecules, that individually modestly slow aging...
Source: Fight Aging! - January 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Genetic Associations with Longevity are Stronger in Women
In this study, we discovered that genetic associations with longevity are on average stronger in females than in males through bio-demographic analyses of genome-wide association studies (GWAS) dataset of 2178 centenarians and 2299 middle-age controls of Chinese Longitudinal Healthy Longevity Study (CLHLS). This discovery is replicated across North and South regions of China, and is further confirmed by North-South discovery/replication analyses of different and independent datasets of Chinese healthy aging candidate genes with CLHLS participants who are not in CLHLS GWAS, including 2972 centenarians and 1992 middle-age co...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Chronic Inflammation and Mitochondrial Dysfunction Interact in the Production of Sarcopenia
Sarcopenia is the name given to the later stages of the characteristic loss of muscle mass and strength that occurs in every individual with aging, eventually leading to weakness and the state of frailty. There are many possible contributing mechanisms, and those mechanisms interact with one another. One important cause is loss of muscle stem cell activity, but this may be driven by any number of other aspects of aging. Another important contribution is dysfunction of neuromuscular junctions, as loss of innervation tends to have a negative impact on tissue maintenance. This again may be driven by any number of causative me...
Source: Fight Aging! - January 18, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Inflammasome as a Target for the Next Generation of Anti-Inflammatory Therapies
With advancing age, a wide range of mechanisms act to provoke the immune system into a state of constant inflammatory signaling and activation. Age-related mitochondrial dysfunction leads to mislocalized mitochondrial DNA fragments that trigger the cGAS-STING pathway to provoke inflammation. Senescent cells produce pro-inflammatory signaling, and their numbers increase with age. Visceral fat tissue produces signaling similar that resulting from infected cells. The increased presence of protein aggregates aggravates immune cells inside and outside of the brain. And so forth. Given all of this, actually fixing the issue of a...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Flavonoid 4,4 ′-dimethoxychalcone is Senolytic
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Flagellin Immunization Modestly Extends Life Span After Late-Life Administration in Mice
The immune system recognizes flagellin as foreign. Flagellin is the protein found in flagellae, the whip-like structures that bacteria use to move around. Attacking and destroying these bacteria is very much a part of the immune system's portfolio of normal activities. Thus immunization with flagellin provokes the immune system into greater activity and responsiveness in the short term, and it has been tested in humans as a vaccine adjuvant, intended to make the immune system respond more effectively to the vaccine delivered alongside flagellin. Interestingly, flagellin immunization also makes the immune system clear out h...
Source: Fight Aging! - January 15, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Continued Assessment of the Fasting Mimicking Diet as an Adjuvant Cancer Therapy
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 12, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Amyloid- β Inhibits Synaptic Proteasomal Function in Alzheimer's Disease
Cells contain many proteasomes, one portion of a broad array of repair and quality control mechanisms. The proteasome is a hollow, capped cylindrical structure made of many component proteins. It admits entry only to proteins that have been decorated with the addition of a ubiquitin molecule. Once inside the proteasome's central chamber, the ubiquinated protein is disassembled into short peptides suitable for reuse in the synthesis of other proteins. This ubiquitin-proteasome system is necessary to prevent the buildup of damaged, misfolded, unfolded, or otherwise unwanted proteins.
It has been noted that proteasomal...
Source: Fight Aging! - January 11, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Consider Bypassing Your Health Insurance to Afford Certain Type 1 Diabetes-Related Medicines and Supplies
Since it ' s January (a new year), and about half of all Americans with employer-sponsored healthcare insurance plans have some deductibles to satisfy before their healthcare insurance really kicks-in to cover much of anything and deductibles reset on January 1, I thought perhaps this might be a good time to write about my own experience with high-deductible insurance plans and some intelligent work-arounds which I ' ve discovered to deal with those. Who knows? You might (as I did) find you actually like using a particular brand or variety of insulin which is not " preferred " by your insurance ' s PBM, or maybe you f...
Source: Scott's Web Log - January 11, 2024 Category: Endocrinology Tags: type 1 diabetes 2024 bypass insurance manufacturer coupons PBM ' PBMs unbranded insulin Source Type: blogs
NRF1 is Neuroprotective via Proteasomal Function
Cells maintain themselves against damage and stress via a range of maintenance processes. These include autophagy, in which proteins and structures are transported to the lysosome to be broken down by enzymes, and the ubiquitin-proteasome system, in which specific proteins are dismantled in the proteasome, among others. It is well demonstrated that upregulation of these processes improves resistance to cell stress, and can also improve long-term health, reducing risk of age-related disease and slowing progression of those conditions. Upregulation of autophagy, for example, is a feature of many interventions that modestly s...
Source: Fight Aging! - January 10, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Chronological Age is Not a Good Component of Patient Risk Assessment
Chronological age is embedded in a great many standardized, widely-used protocols for patient risk assessment. Age-related diseases are, after all, age-related, and this use of chronological age has long seemed a reasonable choice. That said, we are now moving into an era in which novel means of measuring biological age are under development, such as epigenetic clocks.
Biological age is the burden of damage and dysfunction resulting from the causative processes of aging. Obviously, this should better reflect the odds of suffering age-related disease. While biological age correlates with chronological age, there is a...
Source: Fight Aging! - January 9, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Direct Link Between Genomic Instability and Inflammation in Senescent Cells
Aging is characterized by constant sterile inflammation, a state that is disruptive to tissue structure and function. A number of forms of molecular damage have been shown via various mechanisms to provoke this inflammation. Mitochondrial dysfunction, for example causes mitochondrial DNA to mislocalize to the cytoplasm, where it triggers an innate immune response that evolved to recognize the presence of bacterial DNA. Mitochondria are the evolved descendants of ancient symbiotic bacteria, and their remnant DNA is close enough to bacterial genomes for this to occur.
In today's open access paper, researchers discuss ...
Source: Fight Aging! - January 8, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Pharma IT and AI – 2024 Health IT Predictions
Discussions will focus on the nuanced packaging and delivery requirements for MABs, emphasizing the commitment to safety standards while ensuring the drugs’ effectiveness.
AI/Automation in Pharma and Healthcare
In 2024, the pharmaceutical landscape can expect a continued shift as AI continues to reshape drug development and healthcare practices. Across genomics, proteomics, and patient data, AI algorithms are beginning to decipher vast datasets to discover new drug targets, refine clinical trials, and tailor treatments to individual patients. The application of machine learning and deep learning is enhancing the crea...
Source: EMR and HIPAA - January 8, 2024 Category: Information Technology Authors: John Lynn Tags: Analytics/Big Data Health IT Company Healthcare IT Regulations 2024 Health IT Predictions Abpro Adhere Health Angie Franks Archana Hedge BioPhy Curavit Clinical Research Dave Latshaw Definitive Healthcare Dr. Kate Sasser Ian Ch Source Type: blogs
