Klotho as a Biomarker of the Influence of Lifestyle Choice on Health
Klotho is a longevity-associated protein that operates both within the cell and also as a circulating signal protein. It is longevity-associated in the sense that upregulation increases life span and downregulation reduces life span in mice, but also in the sense that measured klotho levels correlate with health and life expectancy in human epidemiological studies. Klotho may largely operate by maintaining kidney function into late life, but researchers have found that it may also help brain cells resist the harmful effects of an aged environment.
In today's open access paper, the authors make the interesting point ...
Source: Fight Aging! - December 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Longevity Industry Feature in Biopharma Dealmakers: Repair Biotechnologies, Deciduous Therapeutics, and More
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. (Source: Fight Aging!)
Source: Fight Aging! - December 4, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Effects of Diet on Life Expectancy
It is somewhat interesting to see a careful analysis of diet and life expectancy, using the sizable UK Biobank population, that does not contain any of the words "calorie", "weight", or "obesity". The effects of calorie intake on health over the long-term are sizable, even if we focus only on mechanisms associated with the gain of weight. Visceral fat is metabolically active, generates an increased burden of senescent cells, and contributes to the chronic inflammation of aging via a range of different mechanisms.
Thus one would assume that buried underneath this set of data on what it is that people eat is a more re...
Source: Fight Aging! - December 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What Do We Need To Have AI-Equipped Nanobots In Medicine
Disease, noun [archaic]: A historical term used to describe various physical and mental ailments that affected organisms, primarily humans, in an era before the advent of comprehensive nanomedical and genetic interventions. In the technologically primitive past, diseases were common causes of discomfort, dysfunction, and mortality, often requiring medical treatment and care. Modern advances and nanobots in medicine have rendered this term obsolete, as conditions previously classified as diseases are now either preventable or entirely curable at the molecular level.
Are we on the brink of a brave new world where disease...
Source: The Medical Futurist - November 30, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Future of Medicine Nanotechnology nanobots nanobots in medicine AI Source Type: blogs
Intestinal Inflammation Increases with Age, and is Greater Still in Patients with Alzheimer's Disease
16s rRNA sequencing allows the microbial populations resident in the gut to be catalogued in detail: which species are present, and relative numbers by species. In the years since this assay became cheap, reliable, and readily available, researchers have built increasingly large human gut microbiome databases from samples obtained over the course of epidemiological studies. The research community has found that the gut microbiome exhibits characteristic differences in older people, marked by a growth in populations of inflammatory microbes and a loss of those species that produce beneficial metabolites. Further, some age-r...
Source: Fight Aging! - November 29, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Assessing Markers of Cellular Senescence in the CALERIE Study of Calorie Restriction
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice. (Source: Fight Aging!)
Source: Fight Aging! - November 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
AI ’ s Unforeseen Medical Discoveries: The Curious Case Of Unusual Associations
Artificial intelligence can do a plethora of astonishing things, which has been discussed thoroughly in the past year. We train models to assist medical work, from administration to image analysis, from triage to mental health support. And every now and then AI has curious medical discoveries, detecting things that – to the best of our human knowledge – should not be detectable from the input data. Like knowing the race of the patient from chest X-rays alone. These unusual associations present brand-new challenges to medical professionals.
In these cases, the medical detective work has a new aim: to understa...
Source: The Medical Futurist - November 28, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Artificial Intelligence in Medicine digital health Healthcare technology AI Source Type: blogs
Applying Proteomics to the Development of Senolytic Therapies
We describe the technological advancements that have enabled researchers to address challenges inherent to the proteomic analysis of blood, such as the wide dynamic range of protein concentrations, and discuss multiple workflows that can be leveraged for the discovery of senescence biomarkers, senolytic targets, and cell-surface proteins. We also highlight how modern mass spectrometry-based technologies will open the door for future clinical applications, develop translationally relevant approaches to quantify aging and cellular senescence, and develop therapeutics for enhancing human healthspan. (Source: Fight Aging!)
Source: Fight Aging! - November 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Amaranth Foundation on Bottlenecks in Aging Research
The Amaranth Foundation is one of a small number of organizations created by high net worth individuals to accelerate progress towards the development of therapies to treat aging, picking and choosing research programs and biotech startups to fund based on the founders' understanding of the science and favored goals. Amaranth has a strong focus on neuroscience, for example. The Amaranth pitch on the importance of focusing on bottlenecks in the research and development process is a more general call to action, however, and an interesting take on how best philanthropic organizations should direct their efforts in order to sp...
Source: Fight Aging! - November 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Novel Mitophagy Inducing Compound
A sizable fraction of research aimed at treating aging involves screening natural compounds in search of those that can modestly slow aging in short-lived animal models. This is because the economics of developing such a compound into a drug or supplement are well understood by investors, and because it dovetails well with the scientific goal of increased understanding of how aging progresses at the level of cellular biochemistry, rather than because it is going to make a big difference for patients. If sizable gains in healthy life span were the driving incentive, the field would look very different, and the emphasis woul...
Source: Fight Aging! - November 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Learning from Laron Syndrome
The longest lived mice are still those engineered to lack functional growth hormone or growth hormone receptor. That record was established more than 20 years ago, and remains in place even as an energetic research and development community focused on treating aging as a medical condition has come into being. In part this is the case because research has largely focused on approaches known to produce lesser effects on aging in mice, such as the discovery of small molecules that mimic portions of the calorie restriction response. In part it is because the pace of development in the life sciences is ever slower than we would...
Source: Fight Aging! - November 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An Aging Clock Derived from Images of the Lens of the Eye
In this study, we used informative lens photographs to generate LensAge as an innovative indicator to reveal aging status of lens based on deep learning (DL) models. Under ideal physiological conditions (both genetic and environmental), biological age should be synchronized with chronological age. While in reality, there are almost always differences between biological age and chronological age, which is considered to result from individually different aging processes. Therefore, we measured the difference between LensAge and chronological age as the LensAge index to assess an individual's aging rate relative to peers, and...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Further Evidence for Reduced Blood Pressure to Lower Risk of Dementia
The raised blood pressure of hypertension causes a great deal of downstream damage. It is a way for low-level biochemical damage associated with aging to become actual physical damage to the body. Pressure damage can occur in delicate tissues throughout the body, and raised blood pressure increases the pace at which capillaries and other small vessels rupture. Further, increased blood pressure can accelerate the development of atherosclerosis, and also contributes to the pathological enlargement and weakening of heart muscle. All of this downstream harm is why forcing a reduction in blood pressure, without addressing any o...
Source: Fight Aging! - November 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Will We All Have To Become Biologically Enhanced Superhumans?
Okay, hands up who can tell who’s the most famous biologically enhanced superhuman in the world? True, it’s a quite close call between Captain America and The Incredible Hulk (sorry Spidey, you’re not even close). But are human-invented superhumans just a thing of a Stan Lee comic, or is it an actual scientific idea from a real laboratory?
As a matter of fact, enhancing human capabilities has been on the minds of people for ages, but it has come a long way from ancient training methods to exoskeletons. Enhancing our abilities, be it permanently or temporarily is a tempting but risky matter. Will it be possibl...
Source: The Medical Futurist - November 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Forecast Artificial Intelligence in Medicine Augmented Reality Bioethics Biotechnology Cyborgization Digital Health Research E-Patients Genomics Health Sensors & Trackers Healthcare Policy Medical Education Robotics Science Ficti Source Type: blogs
