Mitochondrial Transplantation Improves Muscle Function in Old Mice
In this study 15 female mice (24 months old) were randomized into two groups (placebo or mitochondrial transplantation). Isolated mitochondria from a donor mouse of the same sex and age were transplanted into the hindlimb muscles of recipient mice. The results indicated significant increases (ranging between ~36% and ~65%) in basal cytochrome c oxidase and citrate synthase activity as well as ATP levels in mice receiving mitochondrial transplantation relative to the placebo. Moreover, there were significant increases (approximately two-fold) in protein expression of mitochondrial markers in both glycolytic and oxidative mu...
Source: Fight Aging! - April 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How AI is Shaping Drug Discovery at AION Labs
In the fast-paced realm of pharmaceuticals, where innovation can mean the difference between life and death, the integration of artificial intelligence (AI) is reshaping the landscape of drug discovery and development. Mati l, CEO at AION Labs, stands at the forefront of this revolution, pioneering the use of AI to tackle the challenges inherent in the pharma industry.
With a unique combination of expertise in AI and pharmaceuticals, Gill leads AION Labs in its mission to harness the power of technology for the greater good. In a recent video interview below, he shared insights into how AI is transforming drug discovery, e...
Source: EMR and HIPAA - April 25, 2024 Category: Information Technology Authors: John Lynn Tags: AI/Machine Learning Health IT Company Healthcare IT AI in healthcare AION Labs Artificial Intelligence Biotech Startups Data Analysis Drug Discovery Healthcare IT Video Interviews Israel Health IT Israel Pharma Mati Gill Pharma A Source Type: blogs
Reviewing Approaches to Improving Aged Stem Cell Function
A variety of approaches show some promise in improving the function of stem cells in aged tissues. Stem cell populations support their tissue by providing a supply of daughter somatic cells to replace losses. This supply diminishes over time as stem cells reduce their activity for reasons that descend from the known root causes of aging, but which are not fully understood in detail. To the degree that reduced stem cell function is a response to the aged environment rather than a consequence of damage inherent to these cells, then it is useful to find ways to force stem cells to be more active. Whether this is the case may ...
Source: Fight Aging! - April 24, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Biotechnology and biological warfare [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! We welcome Ketan Desai, a physician executive, as we’ll delve into the fascinating and concerning realm of biological warfare and bioterrorism. Join us as we explore historical instances of biological weapons, the implications of genetic technology advancements, and the ethical considerations
Read more…
Biotechnology and biological warfare [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 23, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Emergency Medicine Infectious Disease Source Type: blogs
The Role of Immune Aging in Neurodegenerative Conditions
The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is necessary for defense against pathogens and regeneration following injury. Unresolved, constant inflammation is harmful to tissue structure and function, however, changing cell behavior for the worse. In brain tissue, the effects of inflammatory signaling on the behavior of innate immune cells called microglia appears particularly important. Neurogenerative conditions are characterized by activated microglia. These microglia ar...
Source: Fight Aging! - April 23, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Ambitious Goals at Mitrix Bio
Mitrix Bio is one of the companies developing the means to produce large amounts of mitochondria for transplantation. Cells will take up new mitochondria from the surrounding environment, and mitochondria can be harvested from cell cultures. Mitochondrial function declines with age, the result of (a) gene expression changes in the cell nucleus that alter mitochondrial dynamics and the quality control process of mitophagy, and (b) damage to mitochondrial DNA. Evidence from animal studies suggests that replacing mitochondria in aged tissues produces benefits to health and organ function that last for long enough to be intere...
Source: Fight Aging! - April 23, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Decline in Stemness in Many Human Stem Cell Populations with Aging
In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during human aging, which adds weight to the idea that stem cell deterioration may contribute to human aging. (Source: Fight Aging!)
Source: Fight Aging! - April 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases.
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A Population Study Correlates Air Pollution with Faster Cognitive Aging
https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/
A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Parkinson's Disease in the SENS View of Damage Repair
The Strategies for Engineered Negligible Senescence (SENS) is a view of aging as accumulated damage. Drawing from the extensive scientific literature on aging, the originators of SENS created an outline of the forms of cell and tissue damage that are fundamental causes of aging, in that they occur as a natural side-effect of the normal operation of our cellular biochemistry. So we might consider the loss of vital cells due to declining stem cell function, mutations to nuclear DNA and mitochondrial DNA, cross-linking of vital molecules in the extracellular matrix, accumulated metabolic waste in long-lived cells, generation ...
Source: Fight Aging! - April 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Endothelial Cellular Senescence Contributes to Loss of Capillary Density
The consensus of the research community on senescent cells in old tissues is that (a) their presence causes harm, and (b) treatments based on the selective removal of such cells will be beneficial, reversing many aspects of aging and age-related disease. These cells secrete a pro-inflammatory mix of signal molecules that is disruptive to tissue structure and function when maintained over time. Cells become senescent constantly throughout life, only to be destroyed by programmed cell death or by the immune system. With advancing age, newly created senescent cells are cleared ever more slowly, however, and thus the burden of...
Source: Fight Aging! - April 18, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An Interview with Reason of Repair Biotechnologies on Reversal of Atherosclerosis
As some of you may know, I co-founded Repair Biotechnologies with Bill Cherman. The company is presently on the development of a gene therapy approach now demonstrated to rapidly reverse atherosclerosis in mice, the condition in which fatty plaques grow to narrow blood vessels and weaken blood vessel walls. One of the possible approaches to treating aging as a medical condition is to take the list of causes of human mortality, start at the top, and work down. Atherosclerosis is the single largest cause of death in our species, through the rupture of unstable atherosclerotic plaque leading to heart attack or stroke. The bur...
Source: Fight Aging! - April 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Sea Urchins as a Model of Negligible Senescence
Species that exhibit negligible senescence tend to be long-lived, but more interestingly appear to exhibit few to none of the functional declines of degenerative aging until very late in life, quite unlike the situation for most mammals, and particularly for humans. One can argue that the most useful species that exhibit negligible senescence are those with near relative species that age more normally. The closer the relative, the more likely it is that comparing the biochemistry of the two will lead to new knowledge regarding aging. So naked mole rats versus other, less long-lived mole rats, Brandt's bat versus other shor...
Source: Fight Aging! - April 17, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Higher Taurine Intake in the Diet Correlates with Some Measures of Strength in Middle Age
Taurine is a amino acid mainly found in fish and meat in the diet. It is not an essential amino acid, and can be synthesized in humans. Circulating taurine levels in the bloodstream decline with age by about 50% by middle age for reasons that have yet to be determined. Studies in aged mice and non-human primates have shown modestly improved function and slowed aging following taurine supplementation. Past human studies of taurine supplementation have produced entirely unimpressive outcomes, but given that they predated present aging clocks it may be that the researchers were evaluating the wrong metrics. Taurine may act on...
Source: Fight Aging! - April 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Proximate Causes of Increased Transposon Expression with Age
In today's open access paper, researchers here look at some of the proximate causes of transposable element activation, the details of the epigenetic and transcriptional issues. It is well known that transposable element activity increases with age. These are sequences capable of self-replication in the genome, the remnants of ancient retroviral infections. Transposon activity is repressed in youth, the sequences hidden from transcription machinery within compact regions of the packaged genome, or hidden inside intron sequences that are normally excluded from transcription.
Aging produces a growing dysregulation of ...
Source: Fight Aging! - April 15, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
