Lifestyle Produces a Much Greater Contribution to Human Life Expectancy than a Genetic Risk Score
Since the advent of very large databases of combined human genetic and epidemiological information, the evidence has increasingly leaned to support only a modest effect of genetic variation on human life span variation. Setting aside small populations with rare mutations, lifestyle has a much greater effect on life expectancy than one's genes. Even cases of familial longevity might largely result from transmission of culture, and thus lifestyle choices, rather than transmission of genetic variants.
Today's open access paper reports on data in which both genetic risk and lifestyle risk can be assessed. It is worth no...
Source: Fight Aging! - October 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
More Evidence for Impaired Hearing to Contribute to Cognitive Decline
In conclusion, cochlear implant use seems to boost cognitive trajectories in the first years after implantation. However, long-term prevention of dementia seems to need far more than restoration of hearing loss. (Source: Fight Aging!)
Source: Fight Aging! - October 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Your Insulin of the Future Could Be " Made in China " if Big PBMs Have a Say in the Matter
Back on June 16, 2022, I published an article on LinkedIn entitled "How the Civica Insulin Announcement May Be Disruptive to the PBM Kickback Scheme" (see the article athttps://www.linkedin.com/pulse/how-civica-insulin-announcement-may-disruptive-pbm-scheme-strumello/ if you wish to read it) which predicted that a growing number of insulin biosimilars whose active pharmaceutical ingredients (API ' s) are cultured in offshore laboratories are forecast to hit the U.S. market in the next few years. According to the FDA and the individual companies whom I also follow on LinkedIn, the U.S. Food and Drug Administration (FDA) typ...
Source: Scott's Web Log - October 15, 2023 Category: Endocrinology Tags: 2023 Congress insulin insulin prices lawmakers PBM Pharmacy Benefit Managers Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
« Back to Top
Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pigs as a Model to Explore Links Between the Gut Microbiome and Chronic Inflammation in Aging
This study employed a comprehensive metagenomic analysis encompassing saliva and stool samples obtained from 45 pigs representing three distinct age groups, alongside serum metabolomics and lipidomics profiling. Our findings unveiled discernible modifications in the gut and oral microbiomes, serum metabolome, and lipidome at each age stage. Specifically, we identified 87 microbial species in stool samples and 68 in saliva samples that demonstrated significant age-related changes. Notably, 13 species in stool, including Clostridiales bacterium, Lactobacillus johnsonii, and Oscillibacter spp., exhibited age-dependent alterat...
Source: Fight Aging! - October 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Delivering Senolytic Nanoparticles to Atherosclerotic Plaques in Mice
Cells become senescent in response to stress and damage, and there is a great deal of stress and damage taking place in the toxic environment of an atherosclerotic plaque. These fatty plaques develop with age in blood vessel walls throughout the body. Many contributing factors determine the age of onset and pace of progression of atherosclerosis, but at the center of it all, atherosclerotic plaques form and grow because macrophage cells of the innate immune system fail to keep up with clearance of excess cholesterol delivered from the bloodstream into blood vessel walls. After a plaque becomes established, it contains toxi...
Source: Fight Aging! - October 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Funding for the Longevity Industry Continues, Even in a Poor Market
Setting aside the movements of the broader market from year to year, and noting that this past year has been a poor time for venture funding, we should expect the funding available for biotech companies in the longevity industry to continue to increase in the years ahead. The fundamental reasons for this trend appear at the end of this article: the science looks very promising, there are many good projects sitting on the sidelines waiting for a champion to take them forward, and the upside for investors seems high. A therapy that targets one or more underlying mechanisms of aging will likely be applicable to a long list of...
Source: Fight Aging! - October 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The “Green Pope” Loves Science and Is Cautious of AI
By MIKE MAGEE
By all accounts, they were mutually supportive. He was three years older and the chief scientific adviser to the world’s most powerful religious leader. The Scientific American called him “the greatest scientist of all time,” and not because he won the Nobel Prize in Chemistry a decade earlier for explaining the nuts and bolts of ozone formation. It was his blunt truthfulness and ecological advocacy that earned the organization’s respect.
Paul Crutzan is no longer alive. He died on February 4, 2021 in Mainz, Germany at the age of 87. What attracted the 86 year old “Green Pope” to Paul were t...
Source: The Health Care Blog - October 11, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Climate Change Mike Magee Pope Francis Source Type: blogs
Adoptive Transfer of Regulatory T Cells as a Way to Treat Atherosclerosis
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution. (Source: Fight Aging!)
Source: Fight Aging! - October 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Bonus Features, HLTH Edition – October 11, 2023 – Announcements from Best Buy, General Catalyst, Google Cloud, Microsoft, Walgreens, and more
This article will be a roundup of interesting stories, product announcements, partnerships, research studies, company launches, and more from the annual conference. Because there’s so much happening out there at HLTH that we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
Top Headlines
VC firm General Catalyst is creating Health Assurance Transformation Corp., which will partner with 20+ health system partners to guide their transition to value-based care and potentially acquire a health ...
Source: EMR and HIPAA - October 11, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Acuity aidoc athenahealth b.well Best Buy BrightInsight care.ai Circadian Health CLEAR ClearDATA DatosX DAX Copilot DeepScribe Dexcom DUOS Elation Health Evernorth Health Services General Catalyst Google Source Type: blogs
T Cell Exhaustion and the Role of Infections in Alzheimer's Disease
In this study we examined immune system alterations early in the progression to Alzheimer's disease (AD). We observed multiple changes across the peripheral innate and adaptive immune systems associated with amyloid and cognitive status within our aging cohort. In the innate immune system, we observed increased plasmacytoid and myeloid dendritic cells in amyloid positive participants, but these changes were particularly pronounced in those with mild cognitive impairment. We also observed a decrease in total natural killer cells with amyloid positivity. When the adaptive immune system was examined, we observed increases in ...
Source: Fight Aging! - October 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Arguing for Mitochondrial DNA Damage to Spread Between Neurons in Parkinson's Disease
The most noticeable symptoms of Parkinson's disease occur because of the loss of a small but vital population of dopamine-generating neurons in the brain. The condition is associated with the spread of misfolded, aggregated α-synuclein throughout brain tissue. α-synuclein is one of the few molecules in the body capable of misfolding in ways that encourage other molecules o α-synuclein to also misfold in the same way. It can thus spread from cell to cell, perhaps carried in extracellular vesicles. It is thought that misfolding of α-synuclein often first occurs in the intestines, and only then spreads to the brain throug...
Source: Fight Aging! - October 9, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microglial Proliferation in Alzheimer's Model Mice
Microglia are innate immune cells of the central nervous system, analogous to macrophages elsewhere in the body. In addition to mounting a defense against pathogens and cleaning up metabolic waste, these cells are involved in maintenance of neural connections. Ever more attention is given of late to chronic inflammation in the aging of the brain, and microglia are known to become more active and inflammatory with advancing age, amplifying inflammatory signaling in ways that are disruptive to tissue function.
Some of this microglial inflammatory signaling is due to a growing fraction of senescent microglia, one facet...
Source: Fight Aging! - October 6, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
